Birth-related characteristics, congenital malformation, maternal reproductive history and neuroblastoma: The ESCALE study (SFCE)†
Article first published online: 12 DEC 2007
Copyright © 2007 Wiley-Liss, Inc.
International Journal of Cancer
Volume 122, Issue 10, pages 2315–2321, 15 May 2008
How to Cite
Munzer, C., Menegaux, F., Lacour, B., Valteau-Couanet, D., Michon, J., Coze, C., Bergeron, C., Auvrignon, A., Bernard, F., Thomas, C., Vannier, J.-P., Kanold, J., Rubie, H., Hémon, D. and Clavel, J. (2008), Birth-related characteristics, congenital malformation, maternal reproductive history and neuroblastoma: The ESCALE study (SFCE). Int. J. Cancer, 122: 2315–2321. doi: 10.1002/ijc.23301
SFCE: Société Française de lutte contre les Cancers de l'Enfant et de l'adolescent.
- Issue published online: 17 MAR 2008
- Article first published online: 12 DEC 2007
- Manuscript Accepted: 10 OCT 2007
- Manuscript Received: 19 JUL 2007
- Fondation de France
- Association pour la Recherche contre le Cancer (ARC)
- Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS)
- Agence Française de Sécurité Sanitaire de l'Environnement et du Travail (AFSSET)
- Association Cent pour Sang la Vie
- congenital anomalies;
- risk factors
Since neuroblastoma occurs very early in children's lives, it has been hypothesized that pre- and perinatal factors may play a role in its etiology. This study investigated the role of birth characteristics, congenital malformation and maternal reproductive history in neuroblastoma. The data used were generated by the national population-based case–control study, ESCALE, conducted in France in 2003–2004. The mothers of 191 neuroblastoma cases and 1,681 controls, frequency-matched by age and gender, were interviewed by telephone, using a standardized questionnaire, on several factors including pregnancy, medical history, lifestyle, childhood medical conditions and exposures. A positive association between congenital malformation and all neuroblastoma cases was observed [Odds ratio (OR) = 2.2, 95% confidence interval (95% CI): 1.1–4.5]. Congenital malformations were highly associated to neuroblastoma in children aged less than 1 year (OR = 16.8, 95% CI: 3.1–90), while no association was observed in children aged 1 year or more (OR = 1.0, 95% CI: 0.3–2.9). A negative association with a maternal history of spontaneous abortions was also found (OR = 0.6, 95% CI: 0.4–0.9). The results strongly support the hypothesis that congenital anomalies may be associated with neuroblastoma, particularly in infant (less than 1 year of age). © 2007 Wiley-Liss, Inc.