Early life events and conditions and breast cancer risk: From epidemiology to etiology†
Article first published online: 16 NOV 2007
Copyright © 2007 Wiley-Liss, Inc.
International Journal of Cancer
Volume 122, Issue 3, pages 481–485, 1 February 2008
How to Cite
Trichopoulos, D., Adami, H.-O., Ekbom, A., Hsieh, C.-C. and Lagiou, P. (2008), Early life events and conditions and breast cancer risk: From epidemiology to etiology. Int. J. Cancer, 122: 481–485. doi: 10.1002/ijc.23303
Based on the Third Richard Doll lecture given at the International Agency for Research on Cancer by DT on May 9, 2007 and relying on the collective work of all authors.
- Issue published online: 26 NOV 2007
- Article first published online: 16 NOV 2007
- Manuscript Accepted: 25 OCT 2007
- Manuscript Received: 24 OCT 2007
- W81XWH-05-1-0314 Innovator Award
- US. Department of Defence Breast Cancer Research Program
- Office of the Congressionally Directed Medical Research Programs
- breast cancer;
- birth weight;
- stem cells;
Risk factors for breast cancer—documented by intensive epidemiological investigations and viewed in the context of general principles of carcinogenesis—can be integrated to an etiologic model comprising 3 principal components: the likelihood of breast cancer occurrence depends on the number of mammary tissue-specific stem cells, which is determined in early life; all growth-enhancing mammotropic hormones affect the rate of expansion of initiated clones; and while a pregnancy stimulates the replication of already initiated cells, it conveys long-term protection through differentiation of mammary tissue-specific stem cells. This perspective accommodates much of what is known about the epidemiology and natural history of breast cancer and highlights the role of early life in the origin of this cancer. © 2007 Wiley-Liss, Inc.