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Leukaemia in young children living in the vicinity of German nuclear power plants

  1. Peter Kaatsch†,*,
  2. Claudia Spix,
  3. Renate Schulze-Rath,
  4. Sven Schmiedel,
  5. Maria Blettner

Article first published online: 7 DEC 2007

DOI: 10.1002/ijc.23330

Issue

International Journal of Cancer

International Journal of Cancer

Volume 122, Issue 4, pages 721–726, 15 February 2008

Additional Information

How to Cite

Kaatsch, P., Spix, C., Schulze-Rath, R., Schmiedel, S. and Blettner, M. (2008), Leukaemia in young children living in the vicinity of German nuclear power plants. Int. J. Cancer, 122: 721–726. doi: 10.1002/ijc.23330

Author Information

  1. Institute for Medical Biostatistics, Epidemiology and Informatics, German Childhood Cancer Registry, Obere Zahlbacher Strasse 69, 55131 Mainz, Germany

  1. †

    Fax: +49-6131-17-2968

*Institute for Medical Biostatistics, Epidemiology and Informatics, German Childhood Cancer Registry, Obere Zahlbacher Strasse 69, 55131 Mainz, Germany

Publication History

  1. Issue published online: 14 DEC 2007
  2. Article first published online: 7 DEC 2007
  3. Manuscript Accepted: 8 NOV 2007
  4. Manuscript Received: 19 JUL 2007

Funded by

  • Federal Ministry of the Environment
  • Nature Conservation and Nuclear Safety via the Federal Office for Radiation Protection. Grant Number: StSch 4334

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References

  • 1
    Little J. Epidemiology of childhood cancer. IARC Scientific Publication No. 149. Lyon: International Agency for Research on Cancer, 1999.
  • 2
    Bunin GR. Nongenetic causes of childhood cancer: evidence from international variation, time trends, and risk factor studies. Toxicol Appl Pharmacol 2004; 199: 91–103.
  • 3
    Greaves MF,Alexander FE. An infectious etiology for common acute lymphoblastic leukemia in childhood? Leukemia 1993; 7: 349–60.
  • 4
    Alexander FE,Boyle P,Carli PM,Coebergh JW,Draper GJ,Ekbom A,Levi F,McKinney PA,McWhirter W,Magnani C,Michaels J,Olsen JH, et al. Spatial temporal patterns in childhood leukaemia: further evidence for an infectious origin: EUROCLUS project. Br J Cancer 1998; 77: 812–17.
  • 5
    Schüz J,Morgan G,Böhler E,Kaatsch P,Michaelis J. Atopic disease and childhood acute lymphoblastic leukemia. Int J Cancer 2003; 105: 255–60.
    Direct Link:
  • 6
    United Nations Scientific Committee on the effects of atomic radiation (UNSCEAR). Sources and effects of ionizing radiation; Report 2000, vol. 1. Sources, Annex A: dose assessment methodologies, Chapter III Atmospheric dispersion from a near-surface release. New York: United Nations, 2000.
  • 7
    Doll R,Wakeford R. Risk of childhood cancer from fetal irradiation. Br J Radiol 1997; 70: 130–9.
  • 8
    Committee to assess health risks from exposure to low levels of ionizing radiation. Health risks from exposure to low levels of ionizing radiation: BEIR VII, Phase 2. Board on radiation effects, research division on earth and life studies, national research council of the national academies, 2006.
  • 9
    ICRP99. Low-dose extrapolation of radiation-related cancer risk. Ann ICRP 2005; 35: 1–142.
  • 10
    Tubiana M,Aurengo A,Averbeck D,Masse R. The debate on the use of linear no threshold for assessing the effects of low doses. J Radiol Prot 2006; 26: 317–24.
  • 11
    Bundesministerium der Justiz. Strahlenschutzverordnung vom 20. Juli 2001 (BGBl. I S. 1714, (2002, 1459)), zuletzt geändert durch Artikel 2 Section 3 Abs. 31 des Gesetzes vom 1. September 2005 (BGBl. I S. 2618). Bundesanzeiger, 2005.
  • 12
    Smith JG,Bexon A,Boyer FHC,Harvey M,Jones AL,Kindler T,Mercer J,Haywood SM,Verhoef NB,Haverkate BRW,Artmann A. Assessment of the radiological impact on the population of the European Union from European Union nuclear sites between 1987 and 1996. Luxembourg: Office for Official Publications of the European Communities, 2002.
  • 13
    Forman D,Cook-Mozaffari P,Darby S,Davey G,Stratton I,Doll R,Pike M. Cancer near nuclear installations. Nature 1987; 329: 499–505.
  • 14
    Cook-Mozaffari PJ,Darby SC,Doll R,Forman D,Hermon C,Pike MC,Vincent T. Geographical variation in mortality from leukaemia and other cancers in England and Wales in relation to proximity to nuclear installation, 1969–78. Br J Cancer 1989; 59: 476–85. [erratum: Br J Cancer 1989; 60: 270].
  • 15
    Michaelis J,Keller B,Haaf G,Kaatsch P. Incidence of childhood malignancies in the vicinity of west German nuclear power plants. Cancer Causes Control 1992; 3: 255–63.
  • 16
    Hofmann W,Terschueren C,Richardson DB. Childhood leukemia in the vicinity of the Geesthacht nuclear establishments near Hamburg, Germany. Environ Health Perspect 2007, 115: 947–52.
  • 17
    Kaatsch P,Kaletsch U,Michaelis J. An extended study on childhood malignancies in the vicinity of German nuclear power plants. Cancer Causes Control 1998; 9: 529–33.
  • 18
    Schulze-Rath R,Kaatsch P,Schmiedel S,Spix C,Blettner M. Childhood cancer in the surroundings of German nuclear power plants: report of an ongoing epidemiological study Krebs bei Kindern in der Umgebung von Kernkraftwerken: Bericht zu einer laufenden epidemiologischen Studie. Umweltmed Forsch Prax 2006; 11: 20–6.
  • 19
    Spix C,Schmiedel S,Kaatsch P,Schulze-Rath R,Blettner M. Case-control study on childhood cancer in the vicinity of nuclear power plants in Germany 1980–2003. Eur J Cancer; Doi:10.1016/j.ejca. 2007.10.024.
  • 20
    Kramarova E,Stiller CA. The international classification of childhood cancer. Int J Cancer 1996; 68: 759–65.
    Direct Link:
  • 21
    Cox C,Ma G. Asymptotic confidence bands for generalized nonlinear regression models. Biometrics 1995; 51: 142–50.
  • 22
    Laurier D,Grosche B,Hall P. Risk of childhood leukaemia in the vicinity of nuclear installations. Acta Oncologica 2002; 41: 14–24.
  • 23
    Gardner MJ,Winter PD. Cancer in Cumberland during 1959–78 with reference to cancer in young people around Windscale. Lancet 1984; 1: 216–17.
  • 24
    Sharp L,Black RJ,Harkness EF,McKinney PA. Incidence of childhood leukaemia and non-Hodgkin's lymphoma in the vicinity of nuclear sites in Scotland, 1968–93. Occup Environ Med 1996; 53: 823–31.
  • 25
    Evrard AS,Hémon D,Morin A,Laurier D,Tirmarche M,Backe JC,Chartier M,Clavel J. Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates. Br J Cancer 2006; 94: 1342–7.
  • 26
    Bundesamt für Strahlenschutz. Umweltradioaktivität und Strahlenbelastung, Jahresbericht 2005. Bundesministerium für Umwelt, Naturschutz und Reaktorsicherheit, 2006.
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