• 1
    Varro A,Nemeth J,Bridson J,Lee C,Moore S,Dockray GJ. Processing of the gastrin precursor. Modulation of phosphorylated, sulfated, and amidated products. J Biol Chem 1990; 265: 2147681.
  • 2
    Watson SA,Durrant LG,Morris DL. Growth-promoting action of gastrin on human colonic and gastric tumour cells cultured in vitro. Br J Surg 1988; 75: 3425.
  • 3
    Seva C,Dickinson CJ,Yamada T. Growth-promoting effects of glycine-extended progastrin. Science 1994; 265: 41012.
  • 4
    Smith JP,Fantaskey AP,Liu G,Zagon IS. Identification of gastrin as a growth peptide in human pancreatic cancer. Am J Physiol 1995; 268: R135R141.
  • 5
    Singh P,Walker JP,Townsend CM,Jr,Thompson JC. Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice. Cancer Res 1986; 46: 161216.
  • 6
    Smith JP,Solomon TE. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology 1988; 95: 15418.
  • 7
    Smith JP,Stock EA,Wotring MG,McLaughlin PJ,Zagon IS. Characterization of the CCK-B/gastrin-like receptor in human colon cancer. Am J Physiol 1996; 271: R797R805.
  • 8
    Konturek PC,Nikiforuk A,Kania J,Raithel M,Hahn EG,Muhldorfer S. Activation of NFκB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2. PPARγ and growth factors. Dig Dis Sci 2004; 49: 107583.
  • 9
    Harris JC,Gilliam AD,McKenzie AJ,Evans SA,Grabowska AM,Clarke PA,McWilliams DF,Watson SA. The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas. Cancer Res 2004; 64: 562431.
  • 10
    Ogasa M,Miyazaki Y,Hiraoka S,Kitamura S,Nagasawa Y,Kishida O,Miyazaki T,Kiyohara T,Shinomura Y,Matsuzawa Y. Gastrin activates nuclear factor κB (NFκB) through a protein kinase C dependent pathway involving NFκB inducing kinase, inhibitor κB (IκB) kinase, and tumour necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor. Gut 2003; 52: 81319.
  • 11
    Watson SA,Michaeli D,Grimes S,Morris TM,Robinson G,Varro A,Justin TA,Hardcastle JD. Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res 1996; 56: 8805.
  • 12
    Brett BT,Smith SC,Bouvier CV,Michaeli D,Hochhauser D,Davidson BR,Kurzawinski TR,Watkinson AF,Van Someren N,Pounder RE,Caplin ME. Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer. J Clin Oncol 2002; 20: 422531.
  • 13
    Smith AM,Justin T,Michaeli D,Watson SA. Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer. Clin Cancer Res 2000; 6: 471924.
  • 14
    Gilliam AD,Watson SA,Henwood M,McKenzie AJ,Humphreys JE,Elder J,Iftikhar SY,Welch N,Fielding J,Broome P,Michaeli D. A phase II study of G17DT in gastric carcinoma. Eur J Surg Oncol 2004; 30: 53643.
  • 15
    Yu HG,Schrader H,Otte JM,Schmidt WE,Schmitz F. Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells. Biochem Pharmacol 2004; 67: 13546.
  • 16
    Dubel S,Breitling F,Fuchs P,Zewe M,Gotter S,Welschof M,Moldenhauer G,Little M. Isolation of IgG antibody Fv-DNA from various mouse and rat hybridoma cell lines using the polymerase chain reaction with a simple set of primers. J Immunol Methods 1994; 175: 8995.
  • 17
    Krebber A,Bornhauser S,Burmester J,Honegger A,Willuda J,Bosshard HR,Pluckthun A. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system. J Immunol Methods 1997; 201: 3555.
  • 18
    Barderas R,Shochat S,Martinez-Torrecuadrada J,Altschuh D,Meloen R,Casal JI. A fast mutagenesis procedure to recover soluble and functional scFvs containing amber stop codons from synthetic and semisynthetic antibody libraries. J Immunol Methods 2006; 312: 1829.
  • 19
    Sui J,Li W,Murakami A,Tamin A,Matthews LJ,Wong SK,Moore MJ,Tallarico AS,Olurinde M,Choe H,Anderson LJ,Bellini WJ, et al. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human Mab to S1 protein that blocks receptor association. Proc Natl Acad Sci USA 2004; 101: 253641.
  • 20
    Goletz S,Christensen PA,Kristensen P,Blohm D,Tomlinson I,Winter G,Karsten U. Selection of large diversities of antiidiotypic antibody fragments by phage display. J Mol Biol 2002; 315: 108797.
  • 21
    Martinez-Torrecuadrada J,Cifuentes G,Lopez-Serra P,Saenz P,Martinez A,Casal JI. Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation. Clin Cancer Res 2005; 11: 628090.
  • 22
    Watson SA,Crosbee DM,Morris DL,Robertson JF,Makovec F,Rovati LC,Hardcastle JD. Therapeutic effect of the gastrin receptor antagonist. CR2093 on gastrointestinal tumour cell growth. Br J Cancer 1992; 65: 87983.
  • 23
    Tracy HJ,Gregory RA. Physiological properties of a series of synthetic peptides structurally related to gastrin I. Nature 1964; 204: 9358.
  • 24
    Szabo I,Rumi G,Bodis B,Nemeth P,Mozsik G. Gastrin and pentagastrin enhance the tumour proliferation of human stable cultured gastric adenocarcinoma cells. J Physiol (Paris) 2000; 94: 714.