Carcinogenesis

You have full text access to this OnlineOpen article

Protective role of 1α, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells

  1. Bo-Ying Bao1,2,3,†,
  2. Huei-Ju Ting1,†,
  3. Jong-Wei Hsu1,
  4. Yi-Fen Lee1,‡,*

Article first published online: 17 MAR 2008

DOI: 10.1002/ijc.23460

Issue

International Journal of Cancer

International Journal of Cancer

Volume 122, Issue 12, pages 2699–2706, 15 June 2008

Additional Information

How to Cite

Bao, B.-Y., Ting, H.-J., Hsu, J.-W. and Lee, Y.-F. (2008), Protective role of 1α, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells. Int. J. Cancer, 122: 2699–2706. doi: 10.1002/ijc.23460

Author Information

  1. 1

    Department of Urology, University of Rochester Medical Center, Rochester, NY

  2. 2

    Department of Chemical Engineering, University of Rochester, Rochester, NY

  3. 3

    School of Pharmacy, China Medical University, Taichung, Taiwan

  1. †

    The first two authors contributed equally to this work.

  2. ‡

    Fax: +585-756-4133.

*Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 656, Rochester, NY 14642, USA

Publication History

  1. Issue published online: 9 APR 2008
  2. Article first published online: 17 MAR 2008
  3. Manuscript Accepted: 10 JAN 2008
  4. Manuscript Received: 24 APR 2007

Funded by

  • Department of Defense. Grant Number: PC040630
  • National Science Council. Grant Number: NSC-96-2321-B-039-005-MY2
  • China Medical School. Grant Number: CMU96-096, Taiwan

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (451K)

References

  • 1
    Cadenas E. Biochemistry of oxygen toxicity. Annu Rev Biochem 1989; 58: 79–110.
  • 2
    Datta K,Babbar P,Srivastava T,Sinha S,Chattopadhyay P. p53 Dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress. Int J Biochem Cell Biol 2002; 34: 148–57.
  • 3
    Gorman A,McGowan A,Cotter TG. Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett 1997; 404: 27–33.
  • 4
    Imlay JA,Linn S. DNA damage and oxygen radical toxicity. Science 1988; 240: 1302–9.
  • 5
    Kannan K,Jain SK. Oxidative stress and apoptosis. Pathophysiology 2000; 7: 153–63.
  • 6
    von Harsdorf R,Li PF,Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 1999; 99: 2934–41.
  • 7
    Kehrer JP,Lund LG. Cellular reducing equivalents and oxidative stress. Free Radic Biol Med 1994; 17: 65–75.
  • 8
    Yoshida T,Maulik N,Engelman RM,Ho YS,Magnenat JL,Rousou JA,Flack JE,III,Deaton D,Das DK. Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation 1997; 96: II216–II220.
  • 9
    Beutler E. Study of glucose-6-phosphate dehydrogenase: history and molecular biology. Am J Hematol 1993; 42: 53–8.
    Direct Link:
  • 10
    Hercberg S,Galan P,Preziosi P,Alfarez MJ,Vazquez C. The potential role of antioxidant vitamins in preventing cardiovascular diseases and cancers. Nutrition 1998; 14: 513–20.
  • 11
    Garland CF,Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 1980; 9: 227–31.
  • 12
    Garland FC,Garland CF,Gorham ED,Young JF. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med 1990; 19: 614–22.
  • 13
    Hanchette CL,Schwartz GG. Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer 1992; 70: 2861–9.
    Direct Link:
  • 14
    Anzano MA,Smith JM,Uskokovic MR,Peer CW,Mullen LT,Letterio JJ,Welsh MC,Shrader MW,Logsdon DL,Driver DL, Brown CL,Roberts AB, et al. 1α, 25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat. Cancer Res 1994; 54: 1653–6.
  • 15
    Belleli A,Shany S,Levy J,Guberman R,Lamprecht SA. A protective role of 1,25-dihydroxyvitamin D3 in chemically induced rat colon carcinogenesis. Carcinogenesis 1992; 13: 2293–8.
  • 16
    Lucia MS,Anzano MA,Slayter MV,Anver MR,Green DM,Shrader MW,Logsdon DL,Driver CL,Brown CC,Peer CW,Roberts AB,Sporn MB. Chemopreventive activity of tamoxifen. N-(4-hydroxyphenyl)retinamide, and the vitamin. D analogue. Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate. Cancer Res 1995; 55: 5621–7.
  • 17
    Krishnan AV,Peehl DM,Feldman D. The role of vitamin D in prostate cancer. Recent Results Cancer Res 2003; 164: 205–21.
  • 18
    Lin R,Nagai Y,Sladek R,Bastien Y,Ho J,Petrecca K,Sotiropoulou G,Diamandis EP,Hudson TJ,White JH. Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol 2002; 16: 1243–56.
  • 19
    Peehl DM,Shinghal R,Nonn L,Seto E,Krishnan AV,Brooks JD,Feldman D. Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis. J Steroid Biochem Mol Biol 2004; 92: 131–41.
  • 20
    Bao BY,Hu YC,Ting HJ,Lee YF. Androgen signaling is required for the vitamin D-mediated growth inhibition in human prostate cancer cells. Oncogene 2004; 23: 3350–60.
  • 21
    Tian WN,Braunstein LD,Apse K,Pang J,Rose M,Tian X,Stanton RC. Importance of glucose-6-phosphate dehydrogenase activity in cell death. Am J Physiol 1999; 276: C1121–C1131.
  • 22
    Hissin PJ,Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976; 74: 214–26.
  • 23
    Lapenna D,Ciofani G,Pierdomenico SD,Giamberardino MA,Cuccurullo F. Reaction conditions affecting the relationship between thiobarbituric acid reactivity and lipid peroxides in human plasma. Free Radic Biol Med 2001; 31: 331–5.
  • 24
    Bao BY,Yeh SD,Lee YF. 1α,25-Dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases. Carcinogenesis 2006; 27: 32–42.
  • 25
    Schwartz GG,Whitlatch LW,Chen TC,Lokeshwar BL,Holick MF. Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev 1998; 7: 391–5.
  • 26
    Marinescu VD,Kohane IS,Riva A. The MAPPER database: a multi-genome catalog of putative transcription factor binding sites. Nucleic Acids Res 2005; 33: D91–D97.
  • 27
    Valko M,Rhodes CJ,Moncol J,Izakovic M,Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006; 160: 1–40.
  • 28
    Beutler E. The molecular biology of G6PD variants and other red cell enzyme defects. Annu Rev Med 1992; 43: 47–59.
  • 29
    Vulliamy T,Mason P,Luzzatto L. The molecular basis of glucose-6-phosphate dehydrogenase deficiency. Trends Genet 1992; 8: 138–43.
  • 30
    Ursini MV,Scalera L,Martini G. High levels of transcription driven by a 400 bp segment of the human G6PD promoter. Biochem Biophys Res Commun 1990; 170: 1203–9.
  • 31
    Wagle A,Jivraj S,Garlock GL,Stapleton SR. Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. J Biol Chem 1998; 273: 14968–74.
  • 32
    Cramer CT,Cooke S,Ginsberg LC,Kletzien RF,Stapleton SR,Ulrich RG. Upregulation of glucose-6-phosphate dehydrogenase in response to hepatocellular oxidative stress: studies with diquat. J Biochem Toxicol 1995; 10: 293–8.
    Direct Link:
  • 33
    Fritz RS,Stumpo DJ,Kletzien RF. Glucose-6-phosphate dehydrogenase mRNA sequence abundance in primary cultures of rat hepatocytes. Effect of insulin and dexamethasone. Biochem J 1986; 237: 617–19.
  • 34
    Toniolo D,Filippi M,Dono R,Lettieri T,Martini G. The CpG island in the 5′ region of the G6PD gene of man and mouse. Gene 1991; 102: 197–203.
  • 35
    Koren R,Rocker D,Kotestiano O,Liberman UA,Ravid A. Synergistic anticancer activity of 1,25-dihydroxyvitamin D(3) and immune cytokines: the involvement of reactive oxygen species. J Steroid Biochem Mol Biol 2000; 73: 105–12.
  • 36
    Ravid A,Rocker D,Machlenkin A,Rotem C,Hochman A,Kessler-Icekson G,Liberman UA,Koren R. 1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage. Cancer Res 1999; 59: 862–7.
  • 37
    Sundaram S,Gewirtz DA. The vitamin D3 analog EB 1089 enhances the response of human breast tumor cells to radiation. Radiat Res 1999; 152: 479–86.
  • 38
    Rocker D,Ravid A,Liberman UA,Garach-Jehoshua O,Koren R. 1,25-Dihydroxyvitamin D3 potentiates the cytotoxic effect of TNF on human breast cancer cells. Mol Cell Endocrinol 1994; 106: 157–62.
  • 39
    Wiseman H. Vitamin D is a membrane antioxidant. Ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS Lett 1993; 326: 285–8.
  • 40
    Kuzmenko AI,Morozova RP,Nikolenko IA,Korniets GV,Kholodova Yu D. Effects of vitamin D3 and ecdysterone on free-radical lipid peroxidation. Biochemistry (Mosc) 1997; 62: 609–12.
  • 41
    Horiuchi H,Nagata I,Komoriya K. Protective effect of vitamin D3analogues on endotoxin shock in mice. Agents Actions 1991; 33: 343–8.
  • 42
    Garcion E,Sindji L,Leblondel G,Brachet P,Darcy F. 1,25-Dihydroxyvitamin D3 regulates the synthesis of gamma-glutamyl transpeptidase and glutathione levels in rat primary astrocytes. J Neurochem 1999; 73: 859–66.
    Direct Link:
  • 43
    Sardar S,Chakraborty A,Chatterjee M. Comparative effectiveness of vitamin D3 and dietary vitamin E on peroxidation of lipids and enzymes of the hepatic antioxidant system in Sprague–Dawley rats. Int J Vitam Nutr Res 1996; 66: 39–45.
  • 44
    Kallay E,Bareis P,Bajna E,Kriwanek S,Bonner E,Toyokuni S,Cross HS. Vitamin D receptor activity and prevention of colonic hyperproliferation and oxidative stress. Food Chem Toxicol 2002; 40: 1191–6.
  • 45
    Palmer HG,Larriba MJ,Garcia JM,Ordonez-Moran P,Pena C,Peiro S,Puig I,Rodriguez R,de la Fuente R,Bernad A,Pollan M,Bonilla F, et al. The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat Med 2004; 10: 917–19.
View Full Article (HTML) Get PDF (451K)