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Epidemiology

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Food group intake and risk of subtypes of esophageal and gastric cancer

  1. Stephanie A. Navarro Silvera1,†,*,
  2. Susan T. Mayne2,
  3. Harvey Risch2,
  4. Marilee D. Gammon3,
  5. Thomas L. Vaughan4,5,
  6. Wong-Ho Chow6,
  7. Robert Dubrow2,
  8. Janet B. Schoenberg7,
  9. Janet L. Stanford4,5,
  10. A. Brian West8,
  11. Heidrun Rotterdam9,
  12. William J. Blot10,
  13. Joseph F. Fraumeni Jr.6

Article first published online: 6 JUN 2008

DOI: 10.1002/ijc.23544

Issue

International Journal of Cancer

International Journal of Cancer

Volume 123, Issue 4, pages 852–860, 15 August 2008

Additional Information

How to Cite

Navarro Silvera, S. A., Mayne, S. T., Risch, H., Gammon, M. D., Vaughan, T. L., Chow, W.-H., Dubrow, R., Schoenberg, J. B., Stanford, J. L., West, A. B., Rotterdam, H., Blot, W. J. and Fraumeni, J. F. (2008), Food group intake and risk of subtypes of esophageal and gastric cancer. Int. J. Cancer, 123: 852–860. doi: 10.1002/ijc.23544

Author Information

  1. 1

    Department of Health and Nutrition Sciences, Montclair State University, Montclair, NJ

  2. 2

    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, CT

  3. 3

    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC

  4. 4

    Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA

  5. 5

    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA

  6. 6

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD

  7. 7

    New Jersey Department of Health and Senior Services, Center for Cancer Initiatives, Trenton, NJ

  8. 8

    Department of Pathology, New York University, New York, NY

  9. 9

    Department of Pathology, Columbia University, New York, NY

  10. 10

    International Epidemiology Institute, Rockville, MD

  1. †

    Fax: +973-655-5461.

*Department of Health and Nutrition Sciences, Montclair State University, 1 Normal Avenue, Montclair, NJ 07043, USA

  1. †

    Fax: +973-655-5461.

Publication History

  1. Issue published online: 12 JUN 2008
  2. Article first published online: 6 JUN 2008
  3. Manuscript Accepted: 13 DEC 2007
  4. Manuscript Received: 21 NOV 2005

Funded by

  • USPHS. Grant Numbers: U01-CA57983, U01-CA57949, U01-CA57923
  • National Cancer Institute
  • NIH
  • Department of Health and Human Sciences. Grant Numbers: N02-CP40501, N01-CN05230

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Keywords:

  • esophageal neoplasms;
  • gastric neoplasms;
  • food groups;
  • case–control

Abstract

Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case–control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95% CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95% CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95% CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95% CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95% CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95% CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95% CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma. © 2008 Wiley-Liss, Inc.

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