Night-time work predisposes to non-Hodgkin lymphoma
Article first published online: 11 AUG 2008
Copyright © 2008 Wiley-Liss, Inc.
International Journal of Cancer
Volume 123, Issue 9, pages 2148–2151, 1 November 2008
How to Cite
Lahti, T. A., Partonen, T., Kyyrönen, P., Kauppinen, T. and Pukkala, E. (2008), Night-time work predisposes to non-Hodgkin lymphoma. Int. J. Cancer, 123: 2148–2151. doi: 10.1002/ijc.23566
- Issue published online: 25 AUG 2008
- Article first published online: 11 AUG 2008
- Manuscript Accepted: 18 FEB 2008
- Manuscript Received: 2 AUG 2007
- Academy of Finland. Grant Number: 210262
- circadian clock;
- night-time shift work;
- non-Hodgkin lymphoma
Our aim was to find out whether non-Hodgkin lymphoma (NHL) was more common than expected among night-time shift workers. The Finnish job-exposure matrix (FINJEM) provided estimates of the proportion of exposed persons and the mean level of exposure among the exposed in each occupation. The probability of night-time work in each occupation was assessed, the observed and expected numbers of cancer cases in a cohort of persons born in 1906–1945 during the years of 1971–1995 were calculated, and the cumulative index of night-time work was scored. The cohort compromised of 1,669,272 persons of whom 6,307 (3,813 men and 2,494 women) had NHL during the follow-up. Night-time work increased significantly (p = 0.01) the risk of NHL in men, the overall relative risk being 1.10 (95% confidence interval of 1.03–1.19). Using the lag period of 10 years, the risk ratio was 1.28 (1.03–1.59) for men who worked in night-time shifts to a high degree as compared with those who had not been exposed to night-time work. Night-time workers are cancer prone and have a greater risk of NHL than population on average. © 2008 Wiley-Liss, Inc.