Epidemiology

You have full text access to this OnlineOpen article

Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis

  1. Mikael Eriksson1,*,
  2. Lennart Hardell2,
  3. Michael Carlberg2,
  4. Måns Åkerman3

Article first published online: 11 JUL 2008

DOI: 10.1002/ijc.23589

Issue

International Journal of Cancer

International Journal of Cancer

Volume 123, Issue 7, pages 1657–1663, 1 October 2008

Additional Information

How to Cite

Eriksson, M., Hardell, L., Carlberg, M. and Åkerman, M. (2008), Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis. Int. J. Cancer, 123: 1657–1663. doi: 10.1002/ijc.23589

Author Information

  1. 1

    Department of Oncology, University Hospital, Lund, Sweden

  2. 2

    Department of Oncology, University Hospital, Örebro, Sweden

  3. 3

    Department of Pathology, University Hospital, Lund, Sweden

*Department of Oncology, University Hospital, SE-221 85 Lund, Sweden

Publication History

  1. Issue published online: 28 JUL 2008
  2. Article first published online: 11 JUL 2008
  3. Manuscript Accepted: 20 FEB 2008
  4. Manuscript Received: 4 NOV 2007

Funded by

  • FAS. Grant Number: 2001-0224
  • Cancer-och Allergifonden
  • Nyckelfonden
  • Örebro University Hospital Cancer Fund

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (96K)

References

  • 1
    Jaffe ES,Harris NL,Stein H,Vardiman JW.World Health Organization classification of tumours. Pathology and genetics. Tumours of haematopoetic and lymphoid tissues. Lyon: IARC Press, 2001.
  • 2
    Hardell L,Eriksson M. Is the decline of the increasing incidence of non-Hodgkin lymphoma in Sweden and other countries a result of cancer preventive measures? Environ Health Perspect 2003; 111: 1704–6.
  • 3
    Hardell L,Axelson O. Environmental and occupational aspects on the etiology of non-Hodgkin's lymphoma. Oncol Res 1998; 10: 1–5.
  • 4
    Pluda JM,Venzon DJ,Tosato G,Lietzau J,Wyvill K,Nelson DL,Jaffe ES,Karp JE,Broder S,Yarchoan R. Parameters affecting the development of non-Hodgkin's lymphoma in patients with severe human immunodeficiency virus infection receiving antiretroviral therapy. J Clin Oncol 1993; 11: 1099–107.
  • 5
    Patton DF,Wilkowski CW,Hanson CA,Shapiro R,Gajl-Peczalska KJ,Filipovich AH,McClain KL. Epstein-Barr virus–determined clonality in posttransplant lymphoproliferative disease. Transplantation 1990; 49: 1080–4.
  • 6
    Lehtinen T,Lumio J,Dillner J,Hakama M,Knekt P,Lehtinen M,Teppo L,Leinikki P. Increased risk of malignant lymphoma indicated by elevated Epstein-Barr virus antibodies—a prospective study. Cancer Causes Control 1993; 4: 187–93.
  • 7
    Potter M. Pathogenetic mechanisms in B-cell non-Hodgkin's lymphomas in humans. Cancer Res 1992; 52: 5522S–5528S.
  • 8
    Hardell L,Eriksson M,Lenner P,Lundgren E. Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study. Br J Cancer 1981; 43: 169–76.
  • 9
    Hardell L. Malignant lymphoma of histiocytic type and exposure to phenoxyacetic acids or chlorophenols. Lancet 1979; 1: 55–6.
  • 10
    International Agency for Research on Cancer. Polychlorinated dibenzo-para-dioxins. IARC Monogr Eval Carcinog Risks Hum 1997; 69: 333–343.
  • 11
    Vos JG,Moore JA,Zinkl JG. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals. Environ Health Perspect 1973; 5: 149–62.
  • 12
    Exon JH,Talcott PA,Koller LD. Effect of lead, polychlorinated biphenyls, and cyclophosphamide on rat natural killer cells, interleukin 2, and antibody synthesis. Fundam Appl Toxicol 1985; 5: 158–64.
  • 13
    Lu YC,Wu YC. Clinical findings and immunological abnormalities in Yu-Cheng patients. Environ Health Perspect 1985; 59: 17–29.
  • 14
    Kerkvliet NI,Brauner JA. Mechanisms of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD)-induced humoral immune suppression: evidence of primary defect in T-cell regulation. Toxicol Appl Pharmacol 1987; 87: 18–31.
  • 15
    Faustini A,Settimi L,Pacifici R,Fano V,Zuccaro P,Forastiere F. Immunological changes among farmers exposed to phenoxy herbicides: preliminary observations. Occup Environ Med 1996; 53: 583–5.
  • 16
    Hoar SK,Blair A,Holmes FF,Boysen CD,Robel RJ,Hoover R,Fraumeni JF,Jr. Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA 1986; 256: 1141–7.
  • 17
    Zahm SH,Weisenburger DD,Babbitt PA,Saal RC,Vaught JB,Cantor KP,Blair A. A case-control study of non-Hodgkin's lymphoma and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in eastern Nebraska. Epidemiology 1990; 1: 349–56.
  • 18
    Hardell L,Eriksson M. A case-control study of non-Hodgkin lymphoma and exposure to pesticides. Cancer 1999; 85: 1353–60.
    Direct Link:
  • 19
    Hardell L,Eriksson M,Degerman A. Exposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin's lymphoma. Cancer Res 1994; 54: 2386–9.
  • 20
    Hardell L,Eriksson M,Axelson O,Flesch-Janys D. Epidemiological studies on cancer and exposure to dioxins and related compounds. In: SchecterA,GasiewiczT, eds. Dioxins and health. Hoboken, NJ: John Wiley & Sons, 2003. p 729–64.
  • 21
    Miligi L,Costantini AS,Veraldi A,Benvenuti A,Vineis P. Cancer and pesticides: an overview and some results of the Italian multicenter case-control study on hematolymphopoietic malignancies. Ann N Y Acad Sci 2006; 1076: 366–77.
    Direct Link:
  • 22
    Waddell BL,Zahm SH,Baris D,Weisenburger DD,Holmes F,Burmeister LF,Cantor KP,Blair A. Agricultural use of organophosphate pesticides and the risk of non-Hodgkin's lymphoma among male farmers (United States). Cancer Causes Control 2001; 12: 509–17.
  • 23
    Zheng T,Zahm SH,Cantor KP,Weisenburger DD,Zhang Y,Blair A. Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphoma. J Occup Environ Med 2001; 43: 641–9.
  • 24
    Purdue MP,Hoppin JA,Blair A,Dosemeci M,Alavanja MC. Occupational exposure to organochlorine insecticides and cancer incidence in the agricultural health study. Int J Cancer 2007; 120: 642–9.
    Direct Link:
  • 25
    Colt JS,Davis S,Severson RK,Lynch CF,Cozen W,Camann D,Engels EA,Blair A,Hartge P. Residential insecticide use and risk of non-Hodgkin's lymphoma. Cancer Epidemiol Biomarkers Prev 2006; 15: 251–7.
  • 26
    Rusiecki JA,De Roos A,Lee WJ,Dosemeci M,Lubin JH,Hoppin JA,Blair A,Alavanja MC. Cancer incidence among pesticide applicators exposed to atrazine in the Agricultural Health Study. J Natl Cancer Inst 2004; 96: 1375–82.
  • 27
    Fritschi L,Benke G,Hughes AM,Kricker A,Turner J,Vajdic CM,Grulich A,Milliken S,Kaldor J,Armstrong BK. Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma. Am J Epidemiol 2005; 162: 849–57.
  • 28
    van Balen E,Font R,Cavalle N,Font L,Garcia-Villanueva M,Benavente Y,Brennan P,de Sanjose S. Exposure to non-arsenic pesticides is associated with lymphoma among farmers in Spain. Occup Environ Med 2006; 63: 663–8.
  • 29
    Steinrucken HC,Amrhein N. The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthase. Biochem Biophys Res Commun 1980; 94: 1207–12.
  • 30
    US EPA. U.S. Environmental Protection Agency Registration Eligibility Decision (RED) Glyphosate. EPA-R-93-014. Washington DC: US Environmental Protection Agency, 1993.
  • 31
    World Health Organization. International programme on chemical safety. Glyphosate. Environmental health criteria 159. Geneva: WHO, 1994.
  • 32
    De Roos AJ,Blair A,Rusiecki JA,Hoppin JA,Svec M,Dosemeci M,Sandler DP,Alavanja MC. Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study. Environ Health Perspect 2005; 113: 49–54.
  • 33
    Bolognesi C,Bonatti S,Degan P,Gallerani E,Peluso M,Rabboni R,Roggieri P,Abbondandolo A. Genotoxic activity of glyphosate and its technical formulation Roundup. J Agric Food Chem 1997; 45: 1957–62.
  • 34
    Lioi MB,Scarfi MR,Santoro A,Barbieri R,Zeni O,Di Berardino D,Ursini MV. Genotoxicity and oxidative stress induced by pesticide exposure in bovine lymphocyte cultures in vitro. Mutat Res 1998; 403: 13–20.
  • 35
    Lioi MB,Scarfi MR,Santoro A,Barbieri R,Zeni O,Salvemini F,Di Berardino D,Ursini MV. Cytogenetic damage and induction of pro-oxidant state in human lymphocytes exposed in vitro to gliphosate, vinclozolin, atrazine, and DPX-E9636. Environ Mol Mutagen 1998; 32: 39–46.
    Direct Link:
  • 36
    Hardell L,Eriksson M,Nordstrom M. Exposure to pesticides as risk factor for non-Hodgkin's lymphoma and hairy cell leukemia: pooled analysis of two Swedish case-control studies. Leuk Lymphoma 2002; 43: 1043–9.
  • 37
    McDuffie HH,Pahwa P,McLaughlin JR,Spinelli JJ,Fincham S,Dosman JA,Robson D,Skinnider LF,Choi NW. Non-Hodgkin's lymphoma and specific pesticide exposures in men: cross-Canada study of pesticides and health. Cancer Epidemiol Biomarkers Prev 2001; 10: 1155–63.
  • 38
    De Roos AJ,Zahm SH,Cantor KP,Weisenburger DD,Holmes FF,Burmeister LF,Blair A. Integrative assessment of multiple pesticides as risk factors for non-Hodgkin's lymphoma among men. Occup Environ Med 2003; 60: E11.
  • 39
    Tatham L,Tolbert P,Kjeldsberg C. Occupational risk factors for subgroups of non-Hodgkin's lymphoma. Epidemiology 1997; 8: 551–8.
  • 40
    Rothman N,Cantor KP,Blair A,Bush D,Brock JW,Helzlsouer K,Zahm SH,Needham LL,Pearson GR,Hoover RN,Comstock GW,Strickland PT. A nested case-control study of non-Hodgkin lymphoma and serum organochlorine residues. Lancet 1997; 350: 240–4.
  • 41
    Persson B,Dahlander AM,Fredriksson M,Brage HN,Ohlson CG,Axelson O. Malignant lymphomas and occupational exposures. Br J Ind Med 1989; 46: 516–20.
View Full Article (HTML) Get PDF (96K)