Epidemiology

You have full text access to this OnlineOpen article

Family history of prostate cancer and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study†

  1. Jiyoung Ahn1,
  2. Roxana Moslehi1,
  3. Stephanie J. Weinstein1,
  4. Kirk Snyder2,
  5. Jarmo Virtamo3,
  6. Demetrius Albanes1,‡,*

Article first published online: 10 JUN 2008

DOI: 10.1002/ijc.23591

Issue

International Journal of Cancer

International Journal of Cancer

Volume 123, Issue 5, pages 1154–1159, 1 September 2008

Additional Information

How to Cite

Ahn, J., Moslehi, R., Weinstein, S. J., Snyder, K., Virtamo, J. and Albanes, D. (2008), Family history of prostate cancer and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Int. J. Cancer, 123: 1154–1159. doi: 10.1002/ijc.23591

Author Information

  1. 1

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD

  2. 2

    Information Management Services, Inc., Silver Spring, MD

  3. 3

    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland

  1. ‡

    Fax: +301-496-6829.

*Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, EPS-3044, 6120 Executive Blvd, Bethesda, MD 20892, USA

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

Publication History

  1. Issue published online: 17 JUN 2008
  2. Article first published online: 10 JUN 2008
  3. Manuscript Accepted: 5 MAR 2008
  4. Manuscript Received: 19 OCT 2007

Funded by

  • Department of Health and Human Services (Public Health Service). Grant Numbers: N01-CN-45165, N01-RC-45035, N01-RC-37004
  • Intramural Research Program of the National Institutes of Health
  • Division of Cancer Epidemiology and Genetics
  • National Cancer Institute

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (94K)

Keywords:

  • family history;
  • prostate cancer;
  • height;
  • weight;
  • α-tocopherol;
  • retinol;
  • β-carotene

Abstract

Prostate cancer family history has been associated with increased risk of the malignancy. Most prior studies have been retrospective and subject to recall bias, however, and data evaluating interactions with other important risk factors are limited. We examined the relationship between a family history of prostate cancer and prostate cancer risk in relation to body size, micronutrients and other exposures in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of Finnish male smokers. Family history of cancer information was self-reported once during the study in 1991, and anthropometry was measured by trained personnel. Among 19,652 men with complete data, 1,111 incident cases were identified during up to 12.3 years of follow-up. A first-degree family history of prostate cancer was associated with an overall relative risk (RR) of 1.91 (95% CI = 1.49–2.47) and a RR of 4.16 (95% CI = 2.67–6.49) for advanced disease (stage ≥ 3), adjusted for age and trial intervention. Our data also suggest that to some degree, height, body mass index, and serum α-tocopherol and β-carotene modify the family history and prostate cancer association, although the interactions were not statistically significant. Supplementation with vitamin E or β-carotene did not modify the family history-prostate cancer association. This study provides additional evidence that family history is a significant risk factor for prostate cancer. Published 2008 Wiley-Liss, Inc.

View Full Article (HTML) Get PDF (94K)