Fax: +1-410-614-2632.
Epidemiology
You have full text access to this OnlineOpen article
C-reactive protein and colorectal cancer risk: A systematic review of prospective studies
Article first published online: 4 JUN 2008
DOI: 10.1002/ijc.23606
Copyright © 2008 Wiley-Liss, Inc.
Additional Information
How to Cite
Tsilidis, K. K., Branchini, C., Guallar, E., Helzlsouer, K. J., Erlinger, T. P. and Platz, E. A. (2008), C-reactive protein and colorectal cancer risk: A systematic review of prospective studies. Int. J. Cancer, 123: 1133–1140. doi: 10.1002/ijc.23606
Publication History
- Issue published online: 17 JUN 2008
- Article first published online: 4 JUN 2008
- Manuscript Accepted: 22 FEB 2008
- Manuscript Received: 4 JAN 2008
Funded by
- American Institute for Cancer Research
- Maryland Cigarette Restitution Fund at Johns Hopkins University
- Fulbright
- Hellenic State Scholarships Foundation
References
- 1. CRP or not CRP? That is the question. Arterioscler Thromb Vasc Biol 2005; 25: 1091–4.
- 2,. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448–54.
- 3,,,. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004; 59: 574–80.
- 4. The value of C-reactive protein measurement in rheumatoid arthritis. Semin Arthritis Rheum 1994; 24: 91–104.
- 5,,. Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 2000; 9: 1271–9.
- 6,,,,. Relationship between soluble P-selectin and inflammatory factors (interleukin-6 and C-reactive protein) in colorectal cancer. Thromb Res 2007; 120: 585–90.
- 7,,,,,,. Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry. World J Gastroenterol 2006; 12: 1536–44.
- 8,,,,,. The relationship between reduced vitamin antioxidant concentrations and the systemic inflammatory response in patients with common solid tumours. Clin Nutr 2002; 21: 161–4.
- 9,,,,,,,,. Significance of pre-treatment immunological parameters in colorectal cancer patients with unresectable metastases to the liver. Hepatogastroenterology 1999; 46: 220–7.
- 10,,,,. Is C-reactive protein specific for vascular disease in women? Ann Intern Med 2002; 136: 529–33.
- 11,,,,. C-reactive protein levels are not associated with increased risk for colorectal cancer in women. Ann Intern Med 2005; 142: 425–32.
- 12,,,. C-reactive protein and the risk of incident colorectal cancer. JAMA 2004; 291: 585–90.
- 13,,,,,,,,,. A prospective study of serum C-reactive protein and colorectal cancer risk in men. Cancer Res 2006; 66: 2483–7.
- 14,,,,,,. Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomarkers Prev 2005; 14: 2413–18.
- 15,,,,,,,,,,,, et al. Colorectal cancer and serum C-reactive protein levels: a case-control study nested in the JACC Study. J Epidemiol 2005; 15: S185–9.
- 16,,,,. Plasma C-reactive protein and risk of colorectal cancer in a nested case-control study: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev 2006; 15: 690–5.
- 17,,,,,,,,. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. J Clin Oncol 2006; 24: 5216–22.
- 18,,,,. Plasma C-reactive protein and risk of cancer: a prospective study from Greece. Cancer Epidemiol Biomarkers Prev 2006; 15: 381–4.
- 19,,,,,. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med 2007; 147: 573–7.
- 20,. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol 1992; 135: 1301–9.
- 21,,. Generalized least squares for trend estimation of summarized dose-response data. Stata J 2006; 6: 40–57.
- 22,. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–88.
- 23,,,. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629–34.
- 24,. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088–101.
- 25,,. A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemiol Community Health 2007; 61: 824–33.
- 26,,,,,,,,. Circulating levels of inflammatory cytokines and risk of colorectal adenomas. Cancer Res 2008; 68: 323–8.
- 27,,,,. The relationships of serum CRP and IL-6 levels with lifestyle factors, race/ethinity and colorectal adenoma risk. In: Proceedings of the American Association for Cancer Research, April 2006, Washington, DC.
- 28,,,,,,. C-reactive protein and colorectal adenoma in the CLUE II cohort. Cancer Causes Control 2008; Jan 24 [Electronic publication ahead of print].
- 29,. Point: from animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 2003; 12: 391–400.
- 30,. Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency. Nutr Cancer 2002; 43: 1–21.
- 31,. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004; 287: G7–17.
- 32,,,,. Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation. Carcinogenesis 2000; 21: 757–68.
- 33,,,,,. Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J Gastroenterol Hepatol 2002; 17: 1078–83.Direct Link:
- 34,,,,,,,,,,,, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA 2005; 294: 1799–809.
- 35,,,,,. Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomarkers Prev 2006; 15: 1126–31.
- 36,,. Serum albumin, bilirubin, and uric acid and the anatomic site-specific incidence of colon cancer. J Natl Cancer Inst 1994; 86: 1874–5.
- 37,,,,,,,. Association of common polymorphisms in inflammatory genes interleukin (IL)6. IL8, tumor necrosis factor alpha. NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer. Cancer Res 2003; 63: 3560–6.
- 38,,,,. White blood cell count and the risk of colon cancer. Yonsei Med J 2006; 47: 646–56.
- 39,,,,,,,,,. Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. World J Gastroenterol 2006; 12: 5037–43.
- 40. Cancer prevention in patients with inflammatory bowel disease. Gastroenterol Clin North Am 2002; 31: 1133–44.
- 41,,,,,,,,,,,, et al. Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med 2006; 355: 885–95.
- 42,,,,,,,,,. Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology 2003; 125: 328–36.
- 43,,,,,,,,,,,, et al. Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med 2006; 355: 873–84.
- 44,,,,,. A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst 1991; 83: 355–8.
- 45,. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003; 32: 1–22.

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
