Fax: +852-2872-5197
Cancer Cell Biology
You have full text access to this OnlineOpen article
Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells
Article first published online: 13 JUN 2008
DOI: 10.1002/ijc.23634
Copyright © 2008 Wiley-Liss, Inc.
Additional Information
How to Cite
Chan, D. W., Lee, J. M.F., Chan, P. C.Y. and Ng, I. O.L. (2008), Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells. Int. J. Cancer, 123: 1043–1052. doi: 10.1002/ijc.23634
Publication History
- Issue published online: 17 JUN 2008
- Article first published online: 13 JUN 2008
- Manuscript Accepted: 14 MAR 2008
- Manuscript Received: 27 NOV 2007
Funded by
- Hong Kong Research Grants Council Central Allocation Grant. Grant Number: HKU 1/06C
- University of Hong Kong (URC)
References
- 1,,,,,,,,,. Clonal origin of recurrent hepatocellular carcinomas. Gastroenterology 1989; 96: 527–9.
- 2. Mechanisms of tumor progression. Cancer Res 1986; 46: 2203–7.
- 3,,. The cadherin superfamily: diversity in form and function. J Cell Sci 2001; 114: 629–41.
- 4,. Recent progress in T-cadherin (CDH13, H-cadherin) research. Histol Histopathol 2001; 16: 1287–93.
- 5. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Nat Med 1996; 2: 776–82.
- 6,,,,,. H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo. Carcinogenesis 1998; 19: 1157–9.
- 7,,,. H-cadherin expression in breast cancer. Histopathology 1999; 35: 87–8.Direct Link:
- 8,,,,. Is T-cadherin (CDH13, H-cadherin) expression related to lung metastasis of osteosarcoma? Histopathology 2000; 37: 193–4.Direct Link:
- 9,,,,,,,. Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer 2003; 107: 612–6.Direct Link:
- 10,,,,,,,,,,. Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa. J Clin Oncol 2003; 21: 1472–9.
- 11,,,,. Cell adhesion molecule T-cadherin regulates vascular cell adhesion, phenotype and motility. Exp Cell Res 2004; 293: 207–18.
- 12,,,,,,,,,,,. Expression of adhesion molecule T-cadherin is increased during neointima formation in experimental restenosis. Histochem Cell Biol 2002; 118: 281–90.
- 13,,,,,,,. Increased expression of H/T-cadherin in tumor-penetrating blood vessels. Cancer Res 2000; 60: 4682–8.
- 14,. Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives. J Cancer Res Clin Oncol 2004; 130: 307–19.
- 15,,,. An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways. Virchows Arch 2006; 448: 311–8.
- 16,,,,,,,,,. Investigation in liver tissues and cell lines of the transcription of 13 genes mapping to the 16q24 region that are frequently deleted in hepatocellular carcinoma. Clin Cancer Res 2002; 8: 3178–86.
- 17,,,,,. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 2004; 101: 10308–13.
- 18,,,. High sensitivity mapping of methylated cytosines. Nucleic Acids Res 1994; 22: 2990–7.
- 19. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol 1975; 66: 188–93.
- 20,,,,,,. Hepatocytes sensitized to tumor necrosis factor-alpha cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathways. J Biol Chem 2000; 275: 705–12.
- 21,,,,. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271–9.
- 22,,. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493–501.
- 23,,,,,,,,,. Expression of T-cadherin in tumor cells influences invasive potential of human hepatocellular carcinoma. FASEB J 2006; 20: 2291–301.
- 24,,,. Deletion mapping of chromosome 16q in hepatocellular carcinoma. Br J Cancer 1999; 80: 850–4.
- 25,. Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells. J Pathol 2006; 208: 372–80.Direct Link:
- 26,,,. T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression. Mol Cell Biol 2003; 23: 566–78.
- 27,,,. T-cadherin negatively regulates the proliferation of cutaneous squamous carcinoma cells. J Invest Dermatol 2005; 124: 833–8.
- 28,,,. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Mol Cell Biol 1997; 17: 4792–800.
- 29,,,,,,,,,,. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2002; 2: 29.
- 30,,. Endothelial cadherins and tumor angiogenesis. Exp Cell Res 2006; 312: 659–67.
- 31,,. Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma. Anticancer Res 2006; 26: 3333–5.
- 32,,,,,. CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer. Br J Cancer 2004; 90: 1030–3.
- 33,,,,,,. Loss of T-cadherin (CDH13, H-cadherin) expression in cutaneous squamous cell carcinoma. Lab Invest 2002; 82: 1023–9.
- 34,,. Downregulation of expression of a novel cadherin molecule, T-cadherin, in basal cell carcinoma of the skin. Mol Carcinog 2002; 35: 173–9.Direct Link:
- 35,,,,,,,,,,. Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas. Cancer Res 2002; 62: 3382–6.
- 36,,,,,,,,. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 2000; 29: 110–6.Direct Link:
- 37,,,,,,. Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest. Cancer Res 2005; 65: 6780–8.
- 38,,,,,,. Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent. J Biol Chem 2004; 279: 11957–66.

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
