Epidemiology

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Perinatal characteristics and risk of neuroblastoma

  1. Kimberly J. Johnson1,
  2. Susan E. Puumala1,
  3. John T. Soler2,
  4. Logan G. Spector1,3,†,*

Article first published online: 10 JUN 2008

DOI: 10.1002/ijc.23645

Issue

International Journal of Cancer

International Journal of Cancer

Volume 123, Issue 5, pages 1166–1172, 1 September 2008

Additional Information

How to Cite

Johnson, K. J., Puumala, S. E., Soler, J. T. and Spector, L. G. (2008), Perinatal characteristics and risk of neuroblastoma. Int. J. Cancer, 123: 1166–1172. doi: 10.1002/ijc.23645

Author Information

  1. 1

    Division of Epidemiology/Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN

  2. 2

    Minnesota Cancer Surveillance System, Minnesota Department of Health, St. Paul, MN

  3. 3

    University of Minnesota Cancer Center, Minneapolis, MN

  1. †

    Fax: +612-624-7147.

*Department of Pediatrics, Division of Epidemiology/Clinical Research, Mayo Mail Code 715, 420 Delaware Street S.E., Minneapolis, MN 55455, USA

Publication History

  1. Issue published online: 17 JUN 2008
  2. Article first published online: 10 JUN 2008
  3. Manuscript Accepted: 19 MAR 2008
  4. Manuscript Received: 25 JAN 2008

Funded by

  • Children's Cancer Research Fund, Minneapolis, MN

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Keywords:

  • neuroblastoma;
  • childhood cancer;
  • birth characteristics;
  • antidepressants;
  • risk factors

Abstract

Neuroblastoma (NB), a tumor of the sympathetic nervous system, is the most common infant malignancy. The etiology of NB is largely unknown. We explored the association between birth record variables and subsequent NB development in a population-based case-cohort study in Minnesota by linking the birth and cancer registries. NB cases included 155 children born during 1976–2004 who were diagnosed from 28 days through 14 years of age. The comparison group included 8,752 individuals randomly sampled from the birth cohort of cases. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Controlling for birth year and sex, maternal history of one fetal loss (HR = 1.7, 95% CI 1.2–2.5), maternal prenatal drug-use (recorded starting in 1992) (HR = 5.7, 95% CI 2.3–14) and child's small size for gestational age (HR = 2.1, 95% CI 1.1–4.0) were significantly associated with NB. Age group specific analyses indicated that maternal hypertension (HR = 3.0, 95% CI 1.3–7.2) and maternal age <20 years (HR = 2.6, 95% CI 1.1–6.1) increased risks for infant NB only. Our study provides evidence that a few perinatal exposures as recorded in birth records may play a role in NB etiology. © 2008 Wiley-Liss, Inc.

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