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Carcinogenesis
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CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma
Article first published online: 10 JUN 2008
DOI: 10.1002/ijc.23650
Copyright © 2008 Wiley-Liss, Inc.
Additional Information
How to Cite
Zhang, C., Guo, X., Jiang, G., Zhang, L., Yang, Y., Shen, F., Wu, M. and Wei, L. (2008), CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma. Int. J. Cancer, 123: 998–1004. doi: 10.1002/ijc.23650
Publication History
- Issue published online: 17 JUN 2008
- Article first published online: 10 JUN 2008
- Manuscript Accepted: 28 MAR 2008
- Manuscript Received: 15 JAN 2008
Funded by
- National Natural Science Foundation of China. Grant Numbers: 30471994, 30700981
- National High-Tech Research and Development Program of China. Grant Numbers: 2006AA02A304, 2007AA02Z461
References
- 1. Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 2002; 35: S72–S78.
- 2,,,. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004; 127: S35–S50.
- 3,,,,,,,,,. Risk factors for hepatocellular carcinoma in patients with cirrhosis. Digest Dis Sci 2004; 49: 850–3.
- 4. Switching and signaling at the telomere. Cell 2001; 106: 661–73.
- 5,,,. Telomeres and telomerase in aging, regeneration and cancer. Mol Cell 2003; 15: 164–75.
- 6,. Telomere and telomerase in oncology. Cell Res 2002; 12: 1–7.
- 7,,,. The role of telomeres and telomerase in the pathology of human cancer and aging. Pathology 2006; 38: 103–13.
- 8,,,,,. Clinical implications of telomerase activity in resected hepatocellular carcinoma. Int J Mol Med 1999; 4: 267–71.
- 9,,,,,,,,. Dynamic alteration of telomerase expression and its diagnostic significance in liver or peripheral blood for hepatocellular carcinoma. World J Gastroentero 2006; 12: 4966–72.
- 10,,,,,,,,,,,, et al. The RNAcomponent of human telomerase. Science 1995; 269: 1236–41.
- 11,,,,,,,. Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells. Clin Cancer Res 1999; 5: 2140–7.
- 12,,,,,,. Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription. Clin Cancer Res 2000; 6: 1239–47.
- 13,,,,,,,,,. Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells. Oncogene 2000; 19: 5123–33.
- 14,,,,,,,,,,. p53-dependent down-regulation of telomerase is mediated by p21waf1. J Biol Chem 2004; 279: 50976–85.
- 15,,,,,. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998; 396: 84–8.
- 16,. Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity. Biochim Biophys Acta 1999; 1445: 207–15.
- 17,,,,,,,. Exogenous expression of p16INK4a is associated with decrease in telomerase activity. J Neurooncol 1999; 42: 45–57.
- 18,,,,,. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Cell Growth Differ 2000; 11: 373–84.
- 19,,,,,,,. Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression. J Neurooncol 2001; 55: 149–58.
- 20,,,. E2F-1 represses transcription of the human telomerase reverse transcriptase gene. Nucleic Acids Res 2001; 29: 2789–94.
- 21,,,,,,,. IFN-gamma/IRF-1-induced p27kip1 down-regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer. FEBS Lett 2005; 579: 1027–33.
- 22,,. HPV16-E6 associated hTERT promoter acetylation is E6AP dependent, increased in later passage cells and enhanced by loss of p300. Int J Cancer 2006; 119: 1878–85.Direct Link:
- 23,,,. The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene. J Biol Chem 1999; 274: 37473–8.
- 24. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4: 988–93.
- 25,,,,,,. Genetic and epigenetic events in human hepatocarcinogenesis. Int J Oncol 2001; 18: 1271–8.
- 26,. Hepatocellular carcinoma: molecular pathways and new therapeutic targets. Semin Liver Dis 2005; 25: 212–25.
- 27,,,,,. Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. Cell Res 2003; 13: 319–33.
- 28,,,,,. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999; 96: 8681–6.
- 29,,,,,,,. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 1999; 59: 5438–42.
- 30,,,,,,,,,. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European association for the study of the liver. J Hepatol 2001; 35: 421–30.
- 31,. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7: 462–503.Direct Link:
- 32,,,,. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93: 9821–6.
- 33,,,. Absence of p21(CIP 1), p27(KIP 1) and p 57(KIP 2) methylation in MDS and AML. Leuk Res 2005; 29: 1357–60.
- 34,,,,,. Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors. Oncogene 2002; 21: 8372–8.
- 35,,,. TP53 promoter methylation in human gliomas. Acta Neuropathol (Berl) 2005; 110: 178–84.
- 36,,,,. Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Res 2000; 60: 1211–6.
- 37,,,,,,. Frequent alterations of the p14(ARF) and p16(INK4a) genes in primary central nervous system lymphomas. Cancer Res 2001; 61: 6335–9.
- 38,,. CpG methylation as a mechanism for the regulation of E2F activity. Proc Natl Acad Sci USA 2000; 97: 6481–6.
- 39,,. Absence of p300 gene promoter methylation in acute leukemia. Cancer Genet Cytogenet 2004; 150: 164–7.
- 40,,,,. Polymerase chain reaction-based enzyme immunoassay for quantitation of telomerase activity: application to colorectal cancers. Jpn J Cancer Res 1999; 90: 280–5.
- 41,,,,,,,. Accumulation of DNA methylation is associated with tumor stage in gastric cancer. Cancer 2006; 106: 1250–9.Direct Link:
- 42,,,,,,,. Patterns of genomic instability in gastric cancer: clinical implications and perspectives. Ann Oncol 2006; 17: vii97–vii102.
- 43,,,,,,,,,,,, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 2006; 38: 787–93.
- 44. Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin Liver Dis 2005; 25: 143–54.
- 45,. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003; 349: 2042–54.
- 46. Relevance of DNA methylation in the management of cancer. Lancet Oncol 2003; 4: 351–8.
- 47,,,,,. Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003; 163: 1371–8.
- 48,,. CIMP, at last. Gastroenterology 2005; 129: 1121–4.
- 49,,,,,,,,,,,, et al. Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res 2003; 9: 2912–19.
- 50,,,,,,,,,,,. Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Cancer Res 2001; 61: 8659–63.
- 51,,,,,,,,,. Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia. Blood 2003; 101: 4131–6.
- 52,,,,,,,,,. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011–5.
- 53,,,. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet 1996; 12: 200–4.
- 54,,,,,. Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1995; 1: 249–55.
- 55,,. Telomerase regulation and stem cell behaviour. Curr Opin Cell Biol 2006; 18: 254–60.
- 56,. Regulators of telomerase activity. Am J Resp Cell Mol 2002; 26: 521–4.
- 57,,,. A gene hypermethylation profile of human cancer. Cancer Res 2001; 61: 3225–9.