Trends in esophageal cancer incidence by histology, United States, 1998–2003†
Article first published online: 10 JUN 2008
Published 2008 Wiley-Liss, Inc.
International Journal of Cancer
Volume 123, Issue 6, pages 1422–1428, 15 September 2008
How to Cite
Trivers, K. F., Sabatino, S. A. and Stewart, S. L. (2008), Trends in esophageal cancer incidence by histology, United States, 1998–2003. Int. J. Cancer, 123: 1422–1428. doi: 10.1002/ijc.23691
This article is a US Government work and, as such, is in the public domain in the United States of America.
- Issue published online: 16 JUL 2008
- Article first published online: 10 JUN 2008
- Manuscript Accepted: 16 APR 2008
- Manuscript Received: 17 JAN 2008
- Research Participation Program at the Centers for Disease Control and Prevention (CDC) [Oak Ridge Institute for Science and Education]
- Centers for Disease Control and Prevention's National Program of Cancer Registries
- esophageal neoplasms;
- United States
Esophageal adenocarcinoma rates may be increasing, whereas, squamous cell carcinoma rates appear to be decreasing in the United States. Previous population-based research on esophageal cancer has only covered up to 68% of the country. Additional, updated research on a larger percentage of the country is needed to describe racial, ethnic and regional trends in histologic subtypes of esophageal cancer. Invasive esophageal cancer cases diagnosed between 1998 and 2003 (n = 65,926), collected by the National Program of Cancer Registries or the Surveillance, Epidemiology, and End Results program, were included. These data cover 83% of the US population. Esophageal squamous cell carcinoma incidence fell by 3.6%/year, whereas esophageal adenocarcinoma increased by 2.1%/year. Squamous cell carcinoma rates decreased among both sexes in most racial or ethnic groups, whereas adenocarcinoma rates increased primarily among white or non-Hispanic men. Except for white or non-Hispanic men, squamous cell carcinoma rates were similar to, or greater than, adenocarcinoma rates for men and women of all other races and ethnicities. The largest decrease in squamous cell carcinoma rates occurred in the West census region, which also exhibited no increase in adenocarcinoma rates. The rate of regional and distant-staged adenocarcinomas increased, while rates for local-staged adenocarcinoma remained stable. This is the first article to characterize esophageal cancer trends using data covering the majority of the US. Substantial racial, ethnic and regional variation in esophageal cancer is present in the US. Our work may inform interventions related to tobacco and alcohol use, and overweight/obesity prevention, and provide avenues for further research. Published 2008 Wiley-Liss, Inc.