SEARCH

SEARCH BY CITATION

References

  • 1
    Leytus SP,Loeb KR,Hagen FS,Kurachi K,Davie EW. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. Biochemistry 1988; 27: 106774.
  • 2
    Tsuji A,Torres-Rosado A,Arai T,Chou SH,Kurachi K. Characterization of hepsin, a membrane bound protease. Biomed Biochim Acta 1991; 50: 7913.
  • 3
    Tsuji A,Torres-Rosado A,Arai T,Le Beau MM,Lemons RS,Chou SH,Kurachi K. Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization. J Biol Chem 1991; 266: 1694853.
  • 4
    Somoza JR,Ho JD,Luong C,Ghate M,Sprengeler PA,Mortara K,Shrader WD,Sperandio D,Chan H,McGrath ME,Katz BA. The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain. Structure (Camb) 2003; 11: 112331.
  • 5
    Farley D,Reymond F,Nick H. Cloning and sequence analysis of rat hepsin, a cell surface serine proteinase. Biochim Biophys Acta 1993; 1173: 3502.
  • 6
    Kawamura S,Kurachi S,Deyashiki Y,Kurachi K. Complete nucleotide sequence, origin of isoform and functional characterization of the mouse hepsin gene. Eur J Biochem 1999; 262: 75564.
  • 7
    Vu TK,Liu RW,Haaksma CJ,Tomasek JJ,Howard EW. Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos. J Biol Chem 1997; 272: 3131520.
  • 8
    Li Y,Yu Z,Zhao X,Shen SH. Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform. Biochim Biophys Acta 2005; 1681: 15765.
  • 9
    Dhanasekaran SM,Barrette TR,Ghosh D,Shah R,Varambally S,Kurachi K,Pienta KJ,Rubin MA,Chinnaiyan AM. Delineation of prognostic biomarkers in prostate cancer. Nature 2001; 412: 8226.
  • 10
    Ernst T,Hergenhahn M,Kenzelmann M,Cohen CD,Bonrouhi M,Weninger A,Klaren R,Grone EF,Wiesel M,Gudemann C,Kuster J,Schott W, et al. Decrease and gain of gene expression are equally discriminatory markers for prostate carcinoma: a gene expression analysis on total and microdissected prostate tissue. Am J Pathol 2002; 160: 216980.
  • 11
    Luo J,Duggan DJ,Chen Y,Sauvageot J,Ewing CM,Bittner ML,Trent JM,Isaacs WB. Human prostate cancer and benign prostatic hyperplasia: molecular dissection by gene expression profiling. Cancer Res 2001; 61: 46838.
  • 12
    Magee JA,Araki T,Patil S,Ehrig T,True L,Humphrey PA,Catalona WJ,Watson MA,Milbrandt J. Expression profiling reveals hepsin overexpression in prostate cancer. Cancer Res 2001; 61: 56926.
  • 13
    Stamey TA,Warrington JA,Caldwell MC,Chen Z,Fan Z,Mahadevappa M,McNeal JE,Nolley R,Zhang Z. Molecular genetic profiling of Gleason grade 4/5 prostate cancers compared to benign prostatic hyperplasia. J Urol 2001; 166: 21717.
  • 14
    Welsh JB,Sapinoso LM,Su AI,Kern SG,Wang-Rodriguez J,Moskaluk CA,Frierson HF,Jr,Hampton GM. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res 2001; 61: 59748.
  • 15
    Adib TR,Henderson S,Perrett C,Hewitt D,Bourmpoulia D,Ledermann J,Boshoff C. Predicting biomarkers for ovarian cancer using gene-expression microarrays. Br J Cancer 2004; 90: 68692.
  • 16
    Betsunoh H,Mukai S,Akiyama Y,Fukushima T,Minamiguchi N,Hasui Y,Osada Y,Kataoka H. Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma. Cancer Sci 2007;98:4918.
  • 17
    Tanimoto H,Yan Y,Clarke J,Korourian S,Shigemasa K,Parmley TH,Parham GP,O'Brien TJ. Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer. Cancer Res 1997; 57: 28847.
  • 18
    Zacharski LR,Ornstein DL,Memoli VA,Rousseau SM,Kisiel W. Expression of the factor VII activating protease, hepsin, in situ in renal cell carcinoma. Thromb Haemost 1998; 79: 8767.
  • 19
    Torres-Rosado A,O'Shea KS,Tsuji A,Chou SH,Kurachi K. Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth. Proc Natl Acad Sci USA 1993; 90: 71815.
  • 20
    Kazama Y,Hamamoto T,Foster DC,Kisiel W. Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation. J Biol Chem 1995; 270: 6672.
  • 21
    Guipponi M,Tan J,Cannon PZ,Donley L,Crewther P,Clarke M,Wu Q,Shepherd RK,Scott HS. Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss. Am J Pathol 2007;171:60816.
  • 22
    Wu Q,Yu D,Post J,Halks-Miller M,Sadler JE,Morser J. Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. J Clin Invest 1998; 101: 3216.
  • 23
    Yu IS,Chen HJ,Lee YS,Huang PH,Lin SR,Tsai TW,Lin SW. Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability. Thromb Haemost 2000; 84: 86570.
  • 24
    Xuan JA,Schneider D,Toy P,Lin R,Newton A,Zhu Y,Finster S,Vogel D,Mintzer B,Dinter H,Light D,Parry R, et al. Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture. Cancer Res 2006; 66: 361119.
  • 25
    Klezovitch O,Chevillet J,Mirosevich J,Roberts RL,Matusik RJ,Vasioukhin V. Hepsin promotes prostate cancer progression and metastasis. Cancer Cell 2004; 6: 18595.
  • 26
    Gupta GP,Massague J. Cancer metastasis: building a framework. Cell 2006; 127: 67995.
  • 27
    Loftus SK,Larson DM,Watkins-Chow D,Church DM,Pavan WJ. Generation of RCAS vectors useful for functional genomic analyses. DNA Res 2001; 8: 2216.
  • 28
    Mu D,Chen L,Zhang X,See LH,Koch CM,Yen C,Tong JJ,Spiegel L,Nguyen KC,Servoss A,Peng Y,Pei L, et al. Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell 2003; 3: 297302.
  • 29
    Orsulic S,Li Y,Soslow RA,Vitale-Cross LA,Gutkind JS,Varmus HE. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 2002; 1: 5362.
  • 30
    Xing D,Orsulic S. A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Cancer Res 2006; 66: 894953.
  • 31
    Zhukov A,Hellman U,Ingelman-Sundberg M. Purification and characterization of hepsin from rat liver microsomes. Biochim Biophys Acta 1997; 1337: 8595.
  • 32
    Kunii D,Shimoji M,Nakama S,Ikebe M,Hachiman T,Sato I,Tamaki A,Yamazaki K,Aniya Y. Purification of liver serine protease which activates microsomal glutathione S-transferase: possible involvement of hepsin. Biol Pharm Bull 2006; 29: 86874.
  • 33
    Green KJ,Gaudry CA. Are desmosomes more than tethers for intermediate filaments? Nat Rev 2000; 1: 20816.
  • 34
    Chang L,Goldman RD. Intermediate filaments mediate cytoskeletal crosstalk. Nat Rev 2004; 5: 60113.
  • 35
    Jefferson JJ,Leung CL,Liem RK. Plakins: goliaths that link cell junctions and the cytoskeleton. Nat Rev 2004; 5: 54253.
  • 36
    Herter S,Piper DE,Aaron W,Gabriele T,Cutler G,Cao P,Bhatt AS,Choe Y,Craik CS,Walker N,Meininger D,Hoey T, et al. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem J 2005; 390: 12536.
  • 37
    Kirchhofer D,Peek M,Lipari MT,Billeci K,Fan B,Moran P. Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett 2005; 579: 194550.
  • 38
    Cane S,Bignotti E,Bellone S,Palmieri M,De las Casas L,Roman JJ,Pecorelli S,Cannon MJ,O'Brien T,Santin AD. The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer. Am J Obstet Gynecol 2004; 190: 606.
  • 39
    Underwood LJ,Tanimoto H,Wang Y,Shigemasa K,Parmley TH,O'Brien TJ. Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma. Cancer Res 1999; 59: 44359.
  • 40
    Wallrapp C,Hahnel S,Muller-Pillasch F,Burghardt B,Iwamura T,Ruthenburger M,Lerch MM,Adler G,Gress TM. A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. Cancer Res 2000; 60: 26026.
  • 41
    Nakamura K,Nasu Y,Hongo A,Matsuo T,Kodama J,Ebara S,Nagai A,Abrzua F,Kumon H,Hiramatsu Y. Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines. Int J Oncol 2006; 28: 3938.
  • 42
    Srikantan V,Valladares M,Rhim JS,Moul JW,Srivastava S. HEPSIN inhibits cell growth/invasion in prostate cancer cells. Cancer Res 2002; 62: 681216.
  • 43
    Appel LF,Prout M,Abu-Shumays R,Hammonds A,Garbe JC,Fristrom D,Fristrom J. The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis. Proc Natl Acad Sci USA 1993; 90: 493741.
  • 44
    Garrod DR. Desmosomes and cancer. Cancer Surv 1995; 24: 97111.
  • 45
    Sawada K,Radjabi AR,Shinomiya N,Kistner E,Kenny H,Becker AR,Turkyilmaz MA,Salgia R,Yamada SD,Vande Woude GF,Tretiakova MS,Lengyel E. c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 2007; 67: 16709.
  • 46
    Li G,Schaider H,Satyamoorthy K,Hanakawa Y,Hashimoto K,Herlyn M. Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development. Oncogene 2001; 20: 812535.
  • 47
    Savagner P,Yamada KM,Thiery JP. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 1997; 137: 140319.
  • 48
    Watabe M,Matsumoto K,Nakamura T,Takeichi M. Effect of hepatocyte growth factor on cadherin-mediated cell-cell adhesion. Cell Struct Funct 1993; 18: 11724.