Risk of prostate, breast and colorectal cancer after skin cancer diagnosis

Authors

  • Fabio Levi,

    Corresponding author
    1. Unité d'épidémiologie du Cancer et Registre Vaudois des Tumeurs, Institut de Medicine Sociale et Preventive (IUMSP), Centre Hospitalier Universitaire Vaudois et Université de Lausanne, CHUV-Falaises 1, 1011 Lausanne, Switzerland
    2. Registre Neuchâtelois des Tumeurs, Av. des Cadolles 7, 2000 Neuchâtel, Switzerland
    • Registre Vaudois des Tumeurs, CHUV-Falaises 1, 1011 Lausanne, Switzerland
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  • Lalao Randimbison,

    1. Unité d'épidémiologie du Cancer et Registre Vaudois des Tumeurs, Institut de Medicine Sociale et Preventive (IUMSP), Centre Hospitalier Universitaire Vaudois et Université de Lausanne, CHUV-Falaises 1, 1011 Lausanne, Switzerland
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  • Van-Cong Te,

    1. Unité d'épidémiologie du Cancer et Registre Vaudois des Tumeurs, Institut de Medicine Sociale et Preventive (IUMSP), Centre Hospitalier Universitaire Vaudois et Université de Lausanne, CHUV-Falaises 1, 1011 Lausanne, Switzerland
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  • Manuela Maspoli Conconi,

    1. Registre Neuchâtelois des Tumeurs, Av. des Cadolles 7, 2000 Neuchâtel, Switzerland
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  • Carlo La Vecchia

    1. Istituto di Ricerche Farmacologiche “Mario Negri”, Via La Masa 19, 20156 Milan, Italy
    2. Istituto di Statistica Medica e Biometria “G.A. Maccacaro”, Università degli Studi di Milano, 20133 Milan, Italy
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Abstract

Ultraviolet radiation is the major cause of skin cancer, but promotes vitamin D synthesis, and vitamin D has been inversely related to the risk of several common cancers including prostate, breast and colorectum. We therefore computed the incidence of prostate, breast and colorectal cancer following skin cancer using the datasets of the Swiss cancer Registries of Vaud and Neuchâtel. Between 1974 and 2005, 6,985 histologically confirmed squamous cell skin cancers, 21,046 basal cell carcinomas and 3,346 cutaneous malignant melanomas were registered, and followed up to the end of 2005 for the occurrence of second primary cancer of the prostate, breast and colorectum. Overall, 680 prostate cancers were observed versus 568.3 expected (standardized incidence ratio (SIR) = 1.20; 95% confidence interval (CI): 1.11–1.29), 440 breast cancers were observed versus 371.5 expected (SIR = 1.18; 95% CI: 1.08–1.30) and 535 colorectal cancers were observed versus 464.6 expected (SIR = 1.15; 95% CI: 1.06–1.25). When basal cell, squamous cell and skin melanoma were considered separately, all the SIRs for prostate, breast and colorectal cancers were around or slightly above unity. Likewise, the results were consistent across strata of age at skin cancer diagnosis and location (head and neck versus others), and for male and female colorectal cancers. These findings, based on a population with a long tradition of systematic histologic examination of all surgically treated skin lesions, do not support the hypothesis that prostate, breast and colorectal cancer risk is decreased following skin cancer. © 2008 Wiley-Liss, Inc.

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