R. Levy and R. S. Negrin are co-senior authors.
Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells
Article first published online: 23 SEP 2008
Copyright © 2008 Wiley-Liss, Inc.
International Journal of Cancer
Volume 124, Issue 1, pages 239–244, 1 January 2009
How to Cite
Ai, W. Z., Hou, J.-Z., Zeiser, R., Czerwinski, D., Negrin, R. S. and Levy, R. (2009), Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells. Int. J. Cancer, 124: 239–244. doi: 10.1002/ijc.23881
- Issue published online: 27 OCT 2008
- Article first published online: 23 SEP 2008
- Manuscript Accepted: 11 JUL 2008
- Manuscript Received: 30 APR 2008
- National Institutes of Health. Grant Numbers: CA34233, CA33399, P01HL075462
- Deutsche Krebshilfe, Germany. Grant Number: 108034
- Doris Duke Charitable Foundation
- tumor microenvironment;
- immune escape
There has been accumulating evidence that CD4+CD25+ FoxP3 expressing regulatory T cells (Treg) are highly concentrated in tumors, thereby fostering an immune-privileged microenvironment. Some studies have shown that T-cell receptor (TCR) stimulation can convert conventional T cells into Treg. Follicular lymphoma (FL) B cells can enhance this Treg conversion. We investigated whether FL tumor B cells, as opposed to normal B cells, are unique in their ability to convert effector T cells into Treg. We found that tumor B cells alone, without artificial TCR stimulation, could induce conventional T cells to express FoxP3 and to acquire regulatory function. In contrast to their malignant counterpart, normal B cells did not induce Treg conversion. Treg conversion was independent of the T cell background, as T cells isolated from FL or normal peripheral blood were equally susceptible to being converted by tumor B cells. Our study provides evidence for a tumor-specific mechanism by which FL tumor cells promote immune escape through the induction of Treg. © 2008 Wiley-Liss, Inc.