• 1
    Murakami A,Takahashi M,Jiwajinda S,Koshimizu K,Ohigashi H. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci Biotechnol Biochem 1999; 63: 18112.
  • 2
    Murakami A,Takahashi D,Kinoshita T,Koshimizu K,Kim HW,Yoshihiro A,Nakamura Y,Jiwajinda S,Terao J,Ohigashi H. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite. Carcinogenesis 2002; 23: 795802.
  • 3
    Murakami A,Hayashi R,Tanaka T,Kwon KH,Ohigashi H,Safitri R. Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem Pharmacol 2003; 66: 125361.
  • 4
    Tanaka T,Shimizu M,Kohno H,Yoshitani S,Tsukio Y,Murakami A,Safitri R,Takahashi D,Yamamoto K,Koshimizu K,Ohigashi H,Mori H. Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. Life Sci 2001; 69: 193545.
  • 5
    Murakami A,Matsumoto K,Koshimizu K,Ohigashi H. Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages. Cancer Lett 2003; 195: 1725.
  • 6
    Takada Y,Murakami A,Aggarwal BB. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression ofantiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 2005; 24: 695769.
  • 7
    Balkwill F,Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001; 357: 53945.
  • 8
    Azad N,Rojanasakul Y,Vallyathan V. Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. J Toxicol Environ Health B Crit Rev 2008; 11: 115.
  • 9
    Engels EA. Inflammation in the development of lung cancer: epidemiological evidence. Expert Rev Anticancer Ther 2008; 8: 60515.
  • 10
    Lala PK,Chakraborty C. Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol 2001; 2: 14956.
  • 11
    Wogan GN,Hecht SS,Felton JS,Conney AH,Loeb LA. Environmental and chemical carcinogenesis. Semin Cancer Biol 2004; 14: 47386.
  • 12
    Xie J,Itzkowitz SH. Cancer in inflammatory bowel disease. World J Gastroenterol 2008; 14: 37889.
  • 13
    Itzkowitz SH,Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004; 287: G717.
  • 14
    Hecht SS,Hoffmann D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 1988; 9: 87584.
  • 15
    Kim M,Miyamoto S,Sugie S,Yasui Y,Ishigamori-Suzuki R,Murakami A,Nakagama H,Tanaka T. A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice. In Vivo, in press.
  • 16
    Tanaka T,Kohno H,Suzuki R,Yamada Y,Sugie S,Mori H. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci 2003; 94: 96573.
  • 17
    Hecht SS,Hochalter JB,Villalta PW,Murphy SE. 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor. Proc Natl Acad Sci U S A 2000; 97: 124937.
  • 18
    Hecht SS,Morse MA,Amin S,Stoner GD,Jordan KG,Choi CI,Chung FL. Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. Carcinogenesis 1989; 10: 19014.
  • 19
    Yao R,Rioux N,Castonguay A,You M. Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis. Exp Lung Res 2000; 26: 73142.
  • 20
    Prawan A,Kundu JK,Surh YJ. Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection. Antioxid Redox Signal 2005; 7: 1688703.
  • 21
    Maeda S,Omata M. Inflammation and cancer: role of nuclear factor-kappaB activation. Cancer Sci 2008; 99: 83642.
  • 22
    Naugler WE,Karin M. NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev 2008; 18: 1926.
  • 23
    Miyamoto S,Epifano F,Curini M,Genovese S,Kim M,Ishigamori-Suzuki R,Yasui Y,Sugie S,Tanaka T. A novel prodrug of 4'-geranyloxy-ferulic acid suppresses colitis-related colon carcinogenesis in mice. Nutr Cancer, in press.
  • 24
    Surh YJ. NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities. Asia Pac J Clin Nutr 2008; 17 ( Suppl. 1): 26972.
  • 25
    Cooper HS,Murthy SN,Shah RS,Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 1993; 69: 23849.
  • 26
    Ward JM. Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats. Lab Invest 1974; 30: 50513.
  • 27
    Nikitin AY,Alcaraz A,Anver MR,Bronson RT,Cardiff RD,Dixon D,Fraire AE,Gabrielson EW,Gunning WT,Haines DC,Kaufman MH,Linnoila RI, et al. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res 2004; 64: 230716.
  • 28
    Murakami A,Tanaka T,Lee JY,Surh YJ,Kim HW,Kawabata K,Nakamura Y,Jiwajinda S,Ohigashi H. Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice. Int J Cancer 2004; 110: 48190.
  • 29
    Tanaka T,Miyamoto S,Suzuki R,Yasui Y. Chemoprevention of colon carcinogenesis in dietary non-nutritive compounds. Curr Topics Neutraceut Res 2006; 4: 12752.
  • 30
    Tanaka T,Sugie S. Inhibition of colon carcinogenesis by dietary non-nutritive compounds. J. Toxicol Pathol 2007; 20: 21535.
  • 31
    Tanaka T,Kohno H,Murakami M,Shimada R,Kagami S. Colitis-related rat colon carcinogenesis induced by 1-hydroxy-anthraquinone and methylazoxymethanol acetate (Review). Oncol Rep 2000; 7: 5018.
  • 32
    Murakami A,Miyamoto M,Ohigashi H. Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines. Biofactors 2004; 21: 95101.
  • 33
    Murakami A,Shigemori T,Ohigashi H. Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action. J Nutr 2005; 135: 2987S92S.
  • 34
    Nakamura Y,Yoshida C,Murakami A,Ohigashi H,Osawa T,Uchida K. Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett 2004; 572: 24550.
  • 35
    Gopalakrishnan A,Kong AN. Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cells. Food Chem Toxicol 2008; 46: 125770.
  • 36
    Clemo NK,Collard TJ,Southern SL,Edwards KD,Moorghen M,Packham G,Hague A,Paraskeva C,Williams AC. BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity. Carcinogenesis 2008; 29: 84957.
  • 37
    Stathopoulos GT,Sherrill TP,Cheng DS,Scoggins RM,Han W,Polosukhin VV,Connelly L,Yull FE,Fingleton B,Blackwell TS. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci USA 2007; 104: 185149.
  • 38
    Rajakangas J,Misikangas M,Päivärinta E,Mutanen M. Chemoprevention by white currant is mediated by the reduction of nuclear beta-catenin and NF-kappaB levels in Min mice adenomas. Eur J Nutr 2008; 47: 11522.
  • 39
    Anto RJ,Mukhopadhyay A,Shishodia S,Gairola CG,Aggarwal BB. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis 2002; 23: 15118.
  • 40
    Lee JM,Calkins MJ,Chan K,Kan YW,Johnson JA. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 2003; 278: 1202938.
  • 41
    Abraham NG,Tsenovoy PL,McClung J,Drummond GS. Heme oxygenase: a target gene for anti-diabetic and obesity. Curr Pharm Des 2008; 14: 41221.
  • 42
    Lee J,Lee SK,Lee BU,Lee HJ,Cho NP,Yoon JH,Choi HR,Lee SK,Kim EC. Upregulation of heme oxygenase-1 in oral epithelial dysplasias. Int J Oral Maxillofac Surg 2008; 37: 28792.
  • 43
    Kim HR,Kim S,Kim EJ,Park JH,Yang SH,Jeong ET,Park C,Youn MJ,So HS,Park R. Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin. Lung Cancer 2008; 60: 4756.
  • 44
    Loboda A,Was H,Jozkowicz A,Dulak J. Janus face of Nrf2-HO-1 axis in cancer—friend in chemoprevention, foe in anticancer therapy. Lung Cancer 2008; 60: 13.
  • 45
    Maines MD,Abrahamsson PA. Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution. Urology 1996; 47: 71733.
  • 46
    Sakinah SA,Handayani ST,Hawariah LP. Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Cancer Cell Int 2007; 7: 4.