• 1
    Radisky DC,Kenny PA,Bissell MJ. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem 2007; 101: 8309.
  • 2
    De Wever O,Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200: 42947.
  • 3
    Micke P,Ostman A. Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy. Expert Opin Ther Targets 2005; 9: 121733.
  • 4
    Madani I,De Neve W,Mareel M. Does ionizing radiation stimulate cancer invasion and metastasis? Bull Cancer 2008; 95: 292300.
  • 5
    Albini A,Sporn MB. The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 2007; 7: 13947.
  • 6
    Barth PJ,Westhoff CC. CD34+ fibrocytes: morphology, histogenesis and function. Curr Stem Cell Res Ther 2007; 2: 2217.
  • 7
    Amatangelo MD,Bassi DE,Klein-Szanto AJ,Cukierman E. Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol 2005; 167: 47588.
  • 8
    Desmoulière A,Guyot C,Gabbiani G. The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. Int J Dev Biol 2004; 48: 50917.
  • 9
    Majno G,Gabbiani G,Hirschel BJ,Ryan GB,Statkov PR. Contraction of granulation tissue in vitro: similarity to smooth muscle. Science 1971; 173: 54850.
  • 10
    Powell DW,Adegboyega PA,Di Mari JF,Mifflin RC. Epithelial cells and their neighbors. I. Role of intestinal myofibroblasts in development, repair, and cancer. Am J Physiol Gastrointest Liver Physiol 2005; 289: G2G7.
  • 11
    Hinz B. Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 2007; 127: 52637.
  • 12
    Dvorak HF. Tumors: wounds that do not heal. N Engl J Med 1986; 315: 16509.
  • 13
    Basset P,Bellocq JP,Wolf C,Stoll I,Hutin P,Limacher JM,Podhajcer OL,Chenard MP,Rio MC,Chambon P. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature 1990; 348: 699704.
  • 14
    Dimanche-Boitrel MT,Vakaet L,Jr,Pujuguet P,Chauffert B,Martin MS,Hammann A,Van Roy F,Mareel M,Martin F. In vivo and in vitro invasiveness of a rat colon cancer cell line maintaining E-cadherin expression. An enhancing role of tumor-associated myofibroblasts. Int J Cancer 1994; 56: 51221.
  • 15
    Gaggioli C,Hooper S,Hidalgo-Carcedo C,Grosse R,Marshall JF,Harrington K,Sahai E. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 2007; 9: 1392400.
  • 16
    De Wever O,Nguyen Q-D,Van Hoorde L,Bracke M,Bruyneel E,Gespach C,Mareel M. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J 2004; 18: 101618.
  • 17
    Pardo A,Selman M. Matrix metalloproteases in aberrant fibrotic tissue remodeling. Proc Am Thorac Soc 2006; 3: 3838.
  • 18
    Madani I,De Ruyck K,Goeminne H,De Neve W,Thierens H,Van Meerbeeck J. Predicting risk of radiation-induced lung injury. J Thorac Oncol 2007; 2: 86474.
  • 19
    Kalluri R,Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006; 6: 392401.
  • 20
    Andarawewa KL,Motrescu ER,Chenard M-P,Gansmuller A,Stoll I,Tomasetto C,Rio M-C. Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front. Cancer Res 2005; 65: 1086271.
  • 21
    Brown RD,Ambler SK,Mitchell MD,Long CS. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 2005; 45: 65787.
  • 22
    Willhauck MJ,Mirancea N,Vosseler S,Pavesio A,Boukamp P,Mueller MM,Fusenig NE,Stark H-J. Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation. Carcinogenesis 2007; 28: 595610.
  • 23
    Aishima S,Nishihara Y,Iguchi T,Taguchi K,Taketomi A,Maehara Y,Tsuneyoshi M. Lymphatic spread is related to VEGF-C expression and D2–40-positive myofibroblasts in intrahepatic cholangiocarcinoma. Mod Pathol 2008; 21: 25664.
  • 24
    Christian S,Winkler R,Helfrich I,Boos AM,Besemfelder E,Schadendorf D,Augustin HG. Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. Am J Pathol 2008; 172: 48694.
  • 25
    Casey TM,Eneman J,Crocker A,White J,Tessitore J,Stanley M,Harlow S,Bunn JY,Weaver D,Muss H,Plaut K. Cancer associated fibroblasts stimulated by transforming growth factor β1 (TGF-ß1) increase invasion rate of tumor cells: a population study. Breast Cancer Res Treat 2008; 110: 3949.
  • 26
    Zhu C-Q,Popova SN,Brown ERS,Barsyte-Lovejoy D,Navab R,Shih W,Li M,Lu M,Jurisica I,Penn LZ,Gullberg D,Tsao M-S. Integrin α11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. Proc Natl Acad Sci USA 2007; 104: 117549.
  • 27
    Kuijpers KAJ,Heesakkers JPFA,Jansen CFJ,Schalken JA. Cadherin-11 is expressed in detrusor smooth muscle cells and myofibroblasts of normal human bladder. Eur Urol 2007; 52: 121322.
  • 28
    Direkze NC,Alison MR. Bone marrow and tumour stroma: an intimate relationship. Hematol Oncol 2006; 24: 18995.
  • 29
    Mazzocca A,Coppari R,De Franco R,Cho J-Y,Libermann TA,Pinzani M,Toker A. A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. Cancer Res 2005; 65: 472838.
  • 30
    Shimizu K. Pancreatic stellate cells: molecular mechanism of pancreatic fibrosis. J Gastroenterol Hepatol 2008; 23 ( Suppl 1): S119S121.
  • 31
    Pilling D,Buckley CD,Salmon M,Gomer RH. Inhibition of fibrocyte differentiation by serum amyloid P. J Immunol 2003; 171: 553746.
  • 32
    Jeon ES,Moon HJ,Lee MJ,Song HY,Kim YM,Cho M,Suh D-S,Yoon M-S,Chang CL,Jung JS,Kim JH. Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells. Stem Cells 2008; 26: 78997.
  • 33
    Direkze NC,Hodivala-Dilke K,Jeffery R,Hunt T,Poulsom R,Oukrif D,Alison MR,Wright NA. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 2004; 64: 84925.
  • 34
    Ishii G,Sangai T,Oda T,Aoyagi Y,Hasebe T,Kanomata N,Endoh Y,Okumura C,Okuhara Y,Magae J,Emura M,Ochiya T, et al. Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun 2003; 309: 23240.
  • 35
    Direkze NC,Jeffery R,Hodivala-Dilke K,Hunt T,Playford RJ,Elia G,Poulsom R,Wright NA,Alison MR. Bone marrow-derived stromal cells express lineage-related messenger RNA species. Cancer Res 2006; 66: 12659.
  • 36
    Karnoub AE,Dash AB,Vo AP,Sullivan A,Brooks MW,Bell GW,Richardson AL,Polyak K,Tubo R,Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007; 449: 55763.
  • 37
    Studeny M,Marini FC,Dembinski JL,Zompetta C,Cabreira-Hansen M,Bekele BN,Champlin RE,Andreeff M. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 2004; 96: 1593603.
  • 38
    Di Tommaso L,Pasquinelli G,Damiani S. Smooth muscle cell differentiation in mammary stromo-epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cells. Histopathology 2003; 42: 44856.
  • 39
    Chauhan H,Abraham A,Phillips JRA,Pringle JH,Walker RA,Jones JL. There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions. J Clin Pathol 2003; 56: 2716.
  • 40
    Nakayama H,Enzan H,Miyazaki E,Kuroda N,Toi M,Hiroi M,Yasui W. Presence of vascular adventitial fibroblastic cells in diffuse-type gastric carcinomas. J Clin Pathol 2004; 57: 9702.
  • 41
    Ebrahimsade S,Westhoff CC,Barth PJ. CD34+ fibrocytes are preserved in most invasive lobular carcinomas of the breast. Pathol Res Pract 2007; 203: 6958.
  • 42
    Saika S,Yamanaka O,Sumioka T,Miyamoto T,Miyazaki K-i,Okada Y,Kitano A,Shirai K,Tanaka S-i,Ikeda K. Fibrotic disorders in the eye: targets of gene therapy. Prog Retin Eye Res 2008; 27: 17796.
  • 43
    Abu El-Asrar AM,Struyf S,Van Damme J,Geboes K. Circulating fibrocytes contribute to the myofibroblast population in proliferative vitreoretinopathy epiretinal membranes. Br J Ophthalmol 2008; 92: 699704.
  • 44
    Pulichino A-M,Wang I-M,Caron A,Mortimer J,Auger A,Boie Y,Elias JA,Kartono A,Xu L,Menetski J,Sayegh CE. Identification of transforming growth factor ß1-driven genetic programs of acute lung fibrosis. Am J Respir Cell Mol Biol 2008; 39: 32436.
  • 45
    Mann DA,Mann J. Epigenetic regulation of hepatic stellate cell activation. J Gastroenterol Hepatol 2008; 23 ( Suppl 1): S108S111.
  • 46
    Qian A,Meals RA,Rajfer J,Gonzalez-Cadavid NF. Comparison of gene expression profiles between Peyronie's disease and Dupuytren's contracture. Urology 2004; 64: 399404.
  • 47
    Bacac M,Migliavacca E,Stehle J-C,McKee T,Delorenzi M,Coindre J-M,Guillou L,Stamenkovic I. A gene expression signature that distinguishes desmoid tumours from nodular fasciitis. J Pathol 2006; 208: 54353.
  • 48
    Manetti M,Neumann E,Milia AF,Tarner IH,Bechi P,Matucci-Cerinic M,Ibba-Manneschi L,Müller-Ladner U. Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients. Arthritis Rheum 2007; 56: 34427.
  • 49
    Epperly MW,Franicola D,Zhang X,Nie S,Wang H,Bahnson AB,Shields DS,Goff JP,Shen H,Greenberger JS. Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3−/− marrow chimeric mice. In Vivo 2006; 20: 57382.
  • 50
    Watson MR,Wallace K,Gieling RG,Manas DM,Jaffray E,Hay RT,Mann DA,Oakley F. NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. J Hepatol 2008; 48: 58997.
  • 51
    Kang H-R,Lee CG,Homer RJ,Elias JA. Semaphorin 7A plays a critical role in TGF-ß1-induced pulmonary fibrosis. J Exp Med 2007; 204: 108393.
  • 52
    Dabiri G,Tumbarello DA,Turner CE,Van De Water L. Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-ß1 autocrine loop. J Invest Dermatol doi:10.1038/jid.2008.90.
  • 53
    Caraci F,Gili E,Calafiore M,Failla M,La Rosa C,Crimi N,Sortino MA,Nicoletti F,Copani A,Vancheri C. TGF-ß1 targets the GSK-3ß/ß-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res 2008; 57: 27482.
  • 54
    Li X,Molina-Molina M,Abdul-Hafez A,Uhal V,Xaubet A,Uhal BD. Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2008; 295: L178L185.
  • 55
    Czochra P,Klopcic B,Meyer E,Herkel J,Garcia-Lazaro JF,Thieringer F,Schirmacher P,Biesterfeld S,Galle PR,Lohse AW,Kanzler S. Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice. J Hepatol 2006; 45: 41928.
  • 56
    Baroni SS,Santillo M,Bevilacqua F,Luchetti M,Spadoni T,Mancini M,Fraticelli P,Sambo P,Funaro A,Kazlauskas A,Avvedimento EV,Gabrielli A. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 2006; 354: 266776.
  • 57
    Desmoulière A,Darby A,Gabbiani G. Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest 2003; 83: 1689707.
  • 58
    Wallach-Dayan SB,Golan-Gerstl R,Breuer R. Evasion of myofibroblasts from immune surveillance: a mechanism for tissue fibrosis. Proc Natl Acad Sci USA 2007; 104: 204605.
  • 59
    Gervaz P,Pak-art R,Nivatvongs S,Wolff BG,Larson D,Ringel S. Colorectal adenocarcinoma in cirrhotic patients. J Am Coll Surg 2003; 196: 8749.
  • 60
    Di Sabatino A,Pender SLF,Jackson CL,Prothero JD,Gordon JN,Picariello L,Rovedatti L,Docena G,Monteleone G,Rampton DS,Tonelli F,Corazza GR, et al. Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology 2007; 133: 13749.
  • 61
    Di Sabatino A,Ciccocioppo R,Benazzato L,Sturniolo GC,Corazza GR. Infliximab downregulates basic fibroblast growth factor and vascular endothelial growth factor in Crohn's disease patients. Aliment Pharmacol Ther 2004; 19: 101924.
  • 62
    Fu K,Corbley MJ,Sun L,Friedman JE,Shan F,Papadatos JL,Costa D,Lutterodt F,Sweigard H,Bowes S,Choi M,Boriack-Sjodin PA, et al. SM16, an orally active TGF-ß type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol 2008; 28: 66571.
  • 63
    Allinen M,Beroukhim R,Cai L,Brennan C,Lahti-Domenici J,Huang H,Porter D,Hu M,Chin L,Richardson A,Schnitt S,Sellers WR, et al. Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 2004; 6: 1732.
  • 64
    Micke P,Kappert K,Ohshima M,Sundquist C,Scheidl S,Lindahl P,Heldin C-H,Botling J,Ponten F,Östman A. In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma. J Invest Dermatol 2007; 127: 151623.
  • 65
    Infante JR,Matsubayashi H,Sato N,Tonascia J,Klein AP,Riall TA,Yeo C,Iacobuzio-Donahue C,Goggins M. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol 2007; 25: 31925.
  • 66
    Tsujino T,Seshimo I,Yamamoto H,Ngan CY,Ezumi K,Takemasa I,Ikeda M,Sekimoto M,Matsuura N,Monden M. Stromal myofibroblasts predict disease recurrence for colorectal cancer. Clin Cancer Res 2007; 13: 208290.
  • 67
    Orimo A,Gupta PB,Sgroi DC,Arenzana-Seisdedos F,Delaunay T,Naeem R,Carey VJ,Richardson AL,Weinberg RA. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 33548.
  • 68
    Beppu H,Mwizerwa ON,Beppu Y,Dattwyler MP,Lauwers GY,Bloch KD,Goldstein AM. Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene 2008; 27: 106370.
  • 69
    Bhowmick NA,Chytil A,Plieth D,Gorska AE,Dumont N,Shappell S,Washington MK,Neilson EG,Moses HL. TGF-ß signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 2004; 303: 84851.
  • 70
    Ormestad M,Astorga J,Landgren H,Wang T,Johansson BR,Miura N,Carlsson P. Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 2006; 133: 83343.
  • 71
    De Wever O,Westbroek W,Verloes A,Bloemen N,Bracke M,Gespach C,Bruyneel E,Mareel M. Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-ß or wounding. J Cell Sci 2004; 117: 4691703.
  • 72
    Granot D,Addadi Y,Kalchenko V,Harmelin A,Kunz-Schughart LA,Neeman M. In vivo imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors. Cancer Res 2007; 67: 91809.
  • 73
    Lewis MP,Lygoe KA,Nystrom ML,Anderson WP,Speight PM,Marshall JF,Thomas GJ. Tumour-derived TGF-ß1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. Br J Cancer 2004; 90: 82232.
  • 74
    Milyavsky M,Shats I,Cholostoy A,Brosh R,Buganim Y,Weisz L,Kogan I,Cohen M,Shatz M,Madar S,Kalo E,Goldfinger N, et al. Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. Cancer Cell 2007; 11: 13346.
  • 75
    Denys H,Derycke L,Hendrix A,Westbroek W,Gheldof A,Narine K,Pauwels P,Gespach C,Bracke M,De Wever O. Differential impact of TGF-ß and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. Cancer Lett 2008; 266: 26374.
  • 76
    Löffek S,Zigrino P,Angel P,Anwald B,Krieg T,Mauch C. High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1α and basic fibroblast growth factor-mediated mechanisms. J Invest Dermatol 2005; 124: 63843.
  • 77
    Huet E,Vallée B,Szul D,Verrecchia F,Mourah S,Jester JV,Hoang-Xuan T,Menashi S,Gabison EE. Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing α-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. FASEB J 2008; 22: 114454.
  • 78
    Jin C,Wang F,Wu X,Yu C,Luo Y,McKeehan WL. Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors. Cancer Res 2004; 64: 455562.
  • 79
    Yang G,Rosen DG,Zhang Z,Bast RC,Jr,Mills GB,Colacino JA,Mercado-Uribe I,Liu J. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci USA 2006; 103: 164727.
  • 80
    Dong J,Grunstein J,Tejada M,Peale F,Frantz G,Liang W-C,Bai W,Yu L,Kowalski J,Liang X,Fuh G,Gerber H-P, et al. VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis. EMBO J 2004; 23: 280010.
  • 81
    Lederle W,Stark H-J,Skobe M,Fusenig NE,Mueller MM. Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. Am J Pathol 2006; 169: 176783.
  • 82
    Stuelten CH,DaCosta Byfield S,Arany PR,Karpova TS,Stetler-Stevenson WG,Roberts AB. Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-α and TGF-ß. J Cell Sci 2005; 118: 214353.
  • 83
    Verona EV,Elkahloun AG,Yang J,Bandyopadhyay A,Yeh I-T,Sun L-Z. Transforming growth factor-ß signaling in prostate stromal cells supports prostate carcinoma growth by up-regulating stromal genes related to tissue remodeling. Cancer Res 2007; 67: 573746.
  • 84
    Kellermann MG,Sobral LM,da Silva SD,Zecchin KG,Graner E,Lopes MA,Kowalski LP,Coletta RD. Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation. Oral Oncol 2008; 44: 50917.
  • 85
    Shao J,Sheng GG,Mifflin RC,Powell DW,Sheng H. Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis. Cancer Res 2006; 66: 84655.
  • 86
    Pietras K,Pahler J,Bergers G,Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 2008; 5: 12338.
  • 87
    Satyamoorthy K,Li G,Vaidya B,Patel D,Herlyn M. Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and ß-catenin pathways. Cancer Res 2001; 61: 731824.
  • 88
    Cat B,Stuhlmann D,Steinbrenner H,Alili L,Holtkötter O,Sies H,Brenneisen P. Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species. J Cell Sci 2006; 119: 272738.
  • 89
    Grum-Schwensen B,Klingelhofer J,Berg CH,El-Naaman C,Grigorian M,Lukanidin E,Ambartsumian N. Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene. Cancer Res 2005; 65: 377280.
  • 90
    Daly AJ,McIlreavey L,Irwin CR. Regulation of HGF and SDF-1 expression by oral fibroblasts—implications for invasion of oral cancer. Oral Oncol 2008; 44: 64651.
  • 91
    Joesting MS,Perrin S,Elenbaas B,Fawell SE,Rubin JS,Franco OE,Hayward SW,Cunha GR,Marker PC. Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res 2005; 65: 1042330.
  • 92
    Su G,Blaine SA,Qiao D,Friedl A. Shedding of syndecan-1 by stromal fibroblasts stimulates human breast cancer cell proliferation via FGF2 activation. J Biol Chem 2007; 282: 1490615.
  • 93
    Ao M,Franco OE,Park D,Raman D,Williams K,Hayward SW. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res 2007; 67: 424453.
  • 94
    Taniwaki K,Fukamachi H,Komori K,Ohtake Y,Nonaka T,Sakamoto T,Shiomi T,Okada Y,Itoh T,Itohara S,Seiki M,Yana I. Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. Cancer Res 2007; 67: 431119.
  • 95
    Degen M,Brellier F,Kain R,Ruiz C,Terracciano L,Orend G,Chiquet-Ehrismann R. Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior. Cancer Res 2007; 67: 916979.
  • 96
    Williams CS,Tsujii M,Reese J,Dey SK,DuBois RN. Host cyclooxygenase-2 modulates carcinoma growth. J Clin Invest 2000; 105: 158994.
  • 97
    Sato N,Maehara N,Goggins M. Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res 2004; 64: 69506.
  • 98
    Koukourakis MI,Giatromanolaki A,Harris AL,Sivridis E. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res 2006; 66: 6327.
  • 99
    Hill R,Song Y,Cardiff RD,Van Dyke T. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 2005; 123: 100111.
  • 100
    Patocs A,Zhang L,Xu Y,Weber F,Caldes T,Mutter GL,Platzer P,Eng C. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 2007; 357: 254351.
  • 101
    Radisky DC,Levy DD,Littlepage LE,Liu H,Nelson CM,Fata JE,Leake D,Godden EL,Albertson DG,Nieto MA,Werb Z,Bissell MJ. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005; 436: 1237.
  • 102
    De Wever O,Pauwels P,De Vraene B,Sabbah M,Emami S,Redeuilh G,Gespach C,Bracke M,Berx G. Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front. Histochem Cell Biol 2008; 130: 48194.
  • 103
    Doucet C,Jasmin C,Azzarone B. Unusual interleukin-4 and -13 signaling in human normal and tumor lung fibroblasts. Oncogene 2000; 19: 5898905.
  • 104
    Nazareth MR,Broderick L,Simpson-Abelson MR,Kelleher RJ,Jr,Yokota SJ,Bankert RB. Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol 2007; 178: 555262.
  • 105
    Mallat A,Préaux A-M,Serradeil-Le Gal C,Raufaste D,Gallois C,Brenner DA,Bradham C,Maclouf J,Iourgenko V,Fouassier L,Dhumeaux D,Mavier P, et al. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. J Clin Invest 1996; 98: 27718.
  • 106
    Gregoire FM,Smas CM,Sul HS. Understanding adipocyte differentiation. Physiol Rev 1998; 78: 783809.
  • 107
    Zhang S,Mohammed Q,Burbidge A,Morland CM,Roche WR. Cell cultures from bronchial subepithelial myofibroblasts enhance eosinophil survival in vitro. Eur Respir J 1996; 9: 183946.
  • 108
    Nahrendorf M,Swirski FK,Aikawa E,Stangenberg L,Wurdinger T,Figueiredo J-L,Libby P,Weissleder R,Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007; 204: 303747.
  • 109
    Purkerson JM,Smith RS,Pollock SJ,Phipps RP. The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts. Eur J Immunol 2005; 35: 29208.
  • 110
    Wynes MW,Frankel SK,Riches DWH. IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal. J Leukoc Biol 2004; 76: 101927.
  • 111
    Armulik A,Abramsson A,Betsholtz C. Endothelial/pericyte interactions. Circ Res 2005; 97: 51223.
  • 112
    McAlhany SJ,Ressler SJ,Larsen M,Tuxhorn JA,Yang F,Dang TD,Rowley DR. Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. Cancer Res 2003; 63: 585965.
  • 91
    Yoshifuku K,Matsune S,Ohori J,Sagara Y,Fukuiwa T,Kurono Y. IL-4 and TNF-α increased the secretion of eotaxin from cultured fibroblasts of nasal polyps with eosinophil infiltration. Rhinology 2007; 45: 23541.
  • 114
    Koyama H,Kobayashi N,Harada M,Takeoka M,Kawai Y,Sano K,Fujimori M,Amano J,Ohhashi T,Kannagi R,Kimata K,Taniguchi S, et al. Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis. Pivotal role of a hyaluronan-rich tumor microenvironment. Am J Pathol 2008; 172: 17993.
  • 115
    Ceelen WP,Morris S,Paraskeva P,Pattyn P. Surgical trauma, minimal residual disease and locoregional cancer recurrence. Cancer Treat Res 2007; 134: 5169.
  • 116
    Hofer SOP,Molema G,Hermens RAEC,Wanebo HJ,Reichner JS,Hoekstra HJ. The effect of surgical wounding on tumour development. Eur J Surg Oncol 1999; 25: 23143.
  • 117
    Haas S,Park T-W,Hahne JC,Fischer H-P. Influence of preoperative core biopsies on uPA/PAI-1 expression in breast cancer tissue. Virchows Arch 2008; 452: 27783.
  • 118
    Oosterling SJ,van der Bij GJ,van Egmond M,van der Sijp JRM. Surgical trauma and peritoneal recurrence of colorectal carcinoma. Eur J Surg Oncol 2005; 31: 2937.
  • 119
    Jayne DG,Guillou PJ,Thorpe H,Quirke P,Copeland J,Smith AMH,Heath RM,Brown JM. Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol 2007; 25: 30618.
  • 120
    Mynbaev OA,Dollé L,Bracke M. A possible mechanism of peritoneal pH changes during carbon dioxide pneumoperitoneum. Surg Endosc 2007; 21: 48991.
  • 121
    Wright JL,Cordeiro PG,Ben-Porat L,Van Zee KJ,Hudis C,Beal K,McCormick B. Mastectomy with immediate expander-implant reconstruction, adjuvant chemotherapy, and radiation for stage II-III breast cancer: treatment intervals and clinical outcomes. Int J Radiat Oncol Biol Phys 2008; 70: 4350.
  • 122
    McCarthy CM,Pusic AL,Sclafani L,Buchanan C,Fey JV,Disa JJ,Mehrara BJ,Cordeiro PG. Breast cancer recurrence following prosthetic, postmastectomy reconstruction: incidence, detection, and treatment. Plast Reconstr Surg 2008; 121: 3818.
  • 123
    Gervaz P,Hennig R,Buechler M,Soravia C,Brigstock DR,Morel P,Egger JF,Friess H. Long-term expression of fibrogenic cytokines in radiation-induced damage to the internal anal sphincter. Swiss Surg 2003; 9: 1937.
  • 124
    Vozenin-Brotons M-C,Milliat F,Sabourin J-C,de Gouville A-C,François A,Lasser P,Morice P,Haie-Meder C,Lusinchi A,Antoun S,Bourhis J,Mathé D, et al. Fibrogenic signals in patients with radiation enteritis are associated with increased connective tissue growth factor expression. Int J Radiat Oncol Biol Phys 2003; 56: 56172.
  • 125
    Barcellos-Hoff MH,Park C,Wright EG. Radiation and the microenvironment—tumorigenesis and therapy. Nat Rev Cancer 2005; 5: 86775.
  • 126
    Ohuchida K,Mizumoto K,Murakami M,Qian L-W,Sato N,Nagai E,Matsumoto K,Nakamura T,Tanaka M. Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res 2004; 64: 321522.
  • 127
    Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 2004; 85: 4764.
  • 128
    Dworak O,Keilholz L,Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 1997; 12: 1923.
  • 129
    Darnton SJ,Allen SM,Edwards CW,Matthews HR. Histopathological findings in oesophageal carcinoma with and without preoperative chemotherapy. J Clin Pathol 1993; 46: 515.
  • 130
    Webber MM,Trakul N,Thraves PS,Bello-DeOcampo D,Chu WW,Storto PD,Huard TK,Rhim JS,Williams DE. A human prostatic stromal myofibroblast cell line WPMY-1: a model for stromal-epithelial interactions in prostatic neoplasia. Carcinogenesis 1999; 20: 118592.
  • 131
    Smith RA,Lea RA,Weinstein SR,Griffiths LR. Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma. Cancer Lett 2007; 255: 7784.
  • 132
    Zúbor P,Kajo K,Dussan CA,Szunyogh N,Danko J. Rapidly growing nodular pseudoangiomatous stromal hyperplasia of the breast in an 18-year-old girl. APMIS 2006; 114: 38992.
  • 133
    Okoshi K,Ogawa H,Suwa H,Saiga T,Kobayashi H. A case of nodular pseudoangiomatous stromal hyperplasia (PASH). Breast Cancer 2006; 13: 34953.
  • 134
    Morgan MB,Pitha JV. Myofibroblastoma of the breast revisited: an etiologic association with androgens? Hum Pathol 1998; 29: 34751.