Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients

Authors

  • Yi Ding,

    1. Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
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    • The first two authors contributed equally to this work.

  • Bin Chen,

    1. Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
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    • The first two authors contributed equally to this work.

  • Shuang Wang,

    1. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
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  • Liang Zhao,

    1. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
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  • Juanzhi Chen,

    1. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
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  • Yanqing Ding,

    1. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
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  • Longhua Chen,

    Corresponding author
    1. Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
    • Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
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  • Rongcheng Luo

    Corresponding author
    1. Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China
    • Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
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Abstract

Little research has been done to test the usefulness of T-lymphoma invasion and metastasis 1 (Tiam1) as a prognostic marker for hepatocellular carcinoma (HCC). In this study, we investigated Tiam1 expression and its prognostic value for HCC. HCC surgical tissue samples were taken from 152 HCC patients who had been followed up for 5 years. Overexpression of Tiam1 (Tiam1 2+ to 3+) was shown in 63.8% of the cases. The Tiam1 expression level did not correlate with any clinicopathological parameters. However, survival analysis showed that the Tiam1 overexpression group had a significantly shorter overall survival time than the Tiam1 downexpression group (p = 0.008). Multivariate analysis showed that Tiam1 expression was a significant and independent prognostic parameter (p = 0.042) for HCC patients. Tiam1 expression may be a novel and independent predictor for the prognosis of HCC patients. © 2008 Wiley-Liss, Inc.

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