The first two authors contributed equally to this work.
Early Detection and Diagnosis
Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy
Version of Record online: 9 SEP 2008
Copyright © 2008 Wiley-Liss, Inc.
International Journal of Cancer
Volume 124, Issue 3, pages 659–663, 1 February 2009
How to Cite
Wenske, S., Korets, R., Cronin, A. M., Vickers, A. J., Fleisher, M., Scher, H. I., Pettersson, K., Guillonneau, B., Scardino, P. T., Eastham, J. A. and Lilja, H. (2009), Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy. Int. J. Cancer, 124: 659–663. doi: 10.1002/ijc.23983
- Issue online: 18 NOV 2008
- Version of Record online: 9 SEP 2008
- Accepted manuscript online: 9 SEP 2008 12:00AM EST
- Manuscript Accepted: 14 AUG 2008
- Manuscript Received: 13 MAY 2008
- National Cancer Institute. Grant Numbers: P50-CA92629, SPORE Pilot Project 7
- European Union 6th Framework. Grant Number: LSHC-CT-2004-503011
- Swedish Cancer Society. Grant Number: 3555
Vol. 127, Issue 11, E2, Version of Record online: 28 SEP 2010
Additional Supporting Information may be found in the online version of this article.
|IJC_23983_sm_suppinfofigure1a.tif||342K||Supporting Figure 1. – (a) Comparison of clinical total PSA values, and “laboratory” total PSA values measured in this study (entire group); r2 = 0.9540, slope = 1.22, intercept/constant = −0.49; y = −0.49 + 1.22x. The thick black line is the fitted linear regression line; for comparison, the perfect relationship (clinical tPSA = laboratory tPSA) is shown as the think black line. The concordance correlation coefficient was 0.94.|
|IJC_23983_sm_suppinfofigure1b.tif||334K||Supporting Figure 1. – (b) Comparison of clinical total PSA values, and “laboratory” total PSA values measured in this study; excluding 11 outliers with a total PSA >30 ng/ml; r2 = 0.8574, slope = 1.16, intercept/constant = −0.055; y = −0.055 + 1.16x. The thick black line is the fitted linear regression line; for comparison, the perfect relationship (clinical tPSA = laboratory tPSA) is shown as the think black line. The concordance correlation coefficient was 0.88.|
|IJC_23983_sm_suppinfotables1-4.doc||122K||Supporting Table 1. Clinical and pathological characteristics of cases and controls Supporting Table 2. Median tPSA, fPSA, and hK2 levels among all patients and among patients with tPSA ≤10 ng/ml Supporting Table 3. Multivariable results of conditional logistic regression for prediction of biochemical recurrence following radical prostatectomy among all patients and among patients with total PSA ≤10 ng/ml, controlling for pathologic tumor characteristics Supporting Table 4. Accuracy (defined in terms of the area under the ROC curve [AUC]) of a postoperative pathological prediction base model (including prostatectomy specimen Gleason score, ECE, SVI, LNI, SM, and total PSA), compared to this base model supplemented by free PSA and/or hK2 levels|
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