• 1
    Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1: 2731.
  • 2
    Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol 1992; 3: 6571.
  • 3
    Carmeliet P,Collen D. Molecular basis of angiogenesis. Role of VEGF and VE-cadherin. Ann N Y Acad Sci 902: 24962, 2000; discussion 62–4.
  • 4
    Noguera-Troise I,Daly C,Papadopoulos NJ,Coetzee S,Boland P,Gale NW,Lin HC,Yancopoulos GD,Thurston G. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006; 444: 10327.
  • 5
    Zachary I. VEGF signalling: integration and multi-tasking in endothelial cell biology. Biochem Soc Trans 2003; 31: 11717.
  • 6
    Nguyen NQ,Tabruyn SP,Lins L,Lion M,Cornet AM,Lair F,Rentier-Delrue F,Brasseur R,Martial JA,Struman I. Prolactin/growth hormone-derived antiangiogenic peptides highlight a potential role of tilted peptides in angiogenesis. Proc Natl Acad Sci USA 2006; 103: 1431924.
  • 7
    Kim JS,Yu HK,Ahn JH,Lee HJ,Hong SW,Jung KH,Chang SI,Hong YK,Joe YA,Byun SM,Lee SK,Chung SI, et al. Human apolipoprotein (a) kringle V inhibits angiogenesis in vitro and in vivo by interfering with the activation of focal adhesion kinases. Biochem Biophys Res Commun 2004; 313: 53440.
  • 8
    Kim JS,Chang JH,Yu HK,Ahn JH,Yum JS,Lee SK,Jung KH,Park DH,Yoon Y,Byun SM,Chung SI. Inhibition of angiogenesis and angiogenesis-dependent tumor growth by the cryptic kringle fragments of human apolipoprotein(a). J Biol Chem 2003; 278: 290008.
  • 9
    Gasteiger E,Gattiker A,Hoogland C,Ivanyi I,Appel RD,Bairoch A. ExPASy: The proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res 2003; 31: 37848.
  • 10
    Trousdale RK,Pollak SV,Klein J,Lobel L,Funahashi Y,Feirt N,Lustbader JW. Single-chain bifunctional vascular endothelial growth factor (VEGF)-follicle-stimulating hormone (FSH)-C-terminal peptide (CTP) is superior to the combination therapy of recombinant VEGF plus FSH-CTP in stimulating angiogenesis during ovarian folliculogenesis. Endocrinology 2007; 148: 1296305.
  • 11
    Wang J,Wilcken DE,Wang XL. Cigarette smoke activates caspase-3 to induce apoptosis of human umbilical venous endothelial cells. Mol Genet Metab 2001; 72: 828.
  • 12
    Yi T,Yi Z,Cho SG,Luo J,Pandey MK,Aggarwal BB,Liu M. Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res 2008; 68: 184350.
  • 13
    Stafford LJ,Xia C,Ma W,Cai Y,Liu M. Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res 2002; 62: 5399404.
  • 14
    Dhanabal M,LaRochelle WJ,Jeffers M,Herrmann J,Rastelli L,McDonald WF,Chillakuru RA,Yang M,Boldog FL,Padigaru M,McQueeney KD,Wu F, et al. Angioarrestin: an antiangiogenic protein with tumor-inhibiting properties. Cancer Res 2002; 62: 383441.
  • 15
    Kuo CJ,LaMontagne KR,Jr.,Garcia-Cardena G,Ackley BD,Kalman D,Park S,Christofferson R,Kamihara J,Ding YH,Lo KM,Gillies S,Folkman J, et al. Oligomerization-dependent regulation of motility and morphogenesis by the collagen XVIII NC1/endostatin domain. J Cell Biol 2001; 152: 123346.
  • 16
    Miller WJ,Kayton ML,Patton A,O'Connor S,He M,Vu H,Baibakov G,Lorang D,Knezevic V,Kohn E,Alexander HR,Stirling D, et al. A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay. J Transl Med 2004; 2: 4.
  • 17
    Cao R,Wu HL,Veitonmaki N,Linden P,Farnebo J,Shi GY,Cao Y. Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. Proc Natl Acad Sci USA 1999; 96: 572833.
  • 18
    Kenyon BM,Voest EE,Chen CC,Flynn E,Folkman J,D'Amato RJ. A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci 1996; 37: 162532.
  • 19
    Kenyon BM,Browne F,D'Amato RJ. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res 1997; 64: 9718.
  • 20
    Wu PC,Yang LC,Kuo HK,Huang CC,Tsai CL,Lin PR,Wu PC,Shin SJ,Tai MH. Inhibition of corneal angiogenesis by local application of vasostatin. Mol Vis 2005; 11: 2835.
  • 21
    Yi T,Cho SG,Yi Z,Pang X,Rodriguez M,Wang Y,Sethi G,Aggarwal BB,Liu M. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Cancer Ther 2008; 7: 178996.
  • 22
    Brakenhielm E,Veitonmaki N,Cao R,Kihara S,Matsuzawa Y,Zhivotovsky B,Funahashi T,Cao Y. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA 2004; 101: 247681.
  • 23
    Don AS,Kisker O,Dilda P,Donoghue N,Zhao X,Decollogne S,Creighton B,Flynn E,Folkman J,Hogg PJ. A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. Cancer Cell 2003; 3: 497509.
  • 24
    Zhang G,Dass CR,Sumithran E,Di Girolamo N,Sun LQ,Khachigian LM. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. J Natl Cancer Inst 2004; 96: 68396.
  • 25
    Kumar R,Knick VB,Rudolph SK,Johnson JH,Crosby RM,Crouthamel MC,Hopper TM,Miller CG,Harrington LE,Onori JA,Mullin RJ,Gilmer TM, et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007; 6: 201221.
  • 26
    Tournaire R,Simon MP,le Noble F,Eichmann A,England P,Pouyssegur J. A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep 2004; 5: 2627.
  • 27
    Kruger EA,Duray PH,Price DK,Pluda JM,Figg WD. Approaches to preclinical screening of antiangiogenic agents. Semin Oncol 2001; 28: 5706.
  • 28
    Ye H,Jin L,Hu R,Yi Z,Li J,Wu Y,Xi X,Wu Z. Poly(gamma, L-glutamic acid)-cisplatin conjugate effectively inhibits human breast tumor xenografted in nude mice. Biomaterials 2006; 27: 595865.
  • 29
    Roy H,Bhardwaj S,Yla-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett 2006; 580: 287987.
  • 30
    Sundberg-Smith LJ,Doherty JT,Mack CP,Taylor JM. Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. J Biol Chem 2005; 280: 205564.
  • 31
    Olsson AK,Dimberg A,Kreuger J,Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 2006; 7: 35971.