• 1
    Garcia M,Jemal A. WECMHYSRTMJ. Global Cancer Facts & Figures 2007. Internet 2008(2007) Available at
  • 2
    Garrison M,Nathanson L. Prognosis and staging in melanoma. Semin Oncol 1996; 23: 72533.
  • 3
    Amersi F,Morton DL. The role of sentinel lymph node biopsy in the management of melanoma. Adv Surg 2007; 41: 24156.
  • 4
    Koopal SA,Tiebosch AT,Albertus PD,Plukker JT,Schraffordt KH,Hoekstra HJ. Frozen section analysis of sentinel lymph nodes in melanoma patients. Cancer 2000; 89: 17205.
  • 5
    Stojadinovic A,Allen PJ,Clary BM,Busam KJ,Coit DG. Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma. Ann Surg 2002; 235: 928.
  • 6
    Andonian S,Meterissian SH,Watters AK,Loutfi A. A case of penile melanoma illustrating the low sensitivity of frozen sections in the assessment of sentinel lymph nodes. Can J Urol 2003; 10: 19479.
  • 7
    McCart JA,Ward JM,Lee J,Hu Y,Alexander HR,Libutti SK,Moss B,Bartlett DL. Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes. Cancer Res 2001; 61: 87517.
  • 8
    Chalikonda S,Kivlen MH,O'Malley ME,Eric D,McCart JA,Gorry MC,Yin XY,Brown CK,Zeh HJ,III,Guo ZS,Bartlett DL. Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene. Cancer Gene Ther 2008; 15: 11525.
  • 9
    Guo ZS,Naik A,O'Malley ME,Popovic P,Demarco R,Hu Y,Yin X,Yang S,Zeh HJ,Moss B,Lotze MT,Bartlett DL. The enhanced tumor selectivity of an oncolytic vaccinia lacking the host range and antiapoptosis genes SPI-1 and SPI-2. Cancer Res 2005; 65: 99918.
  • 10
    Kaufman HL,Deraffele G,Mitcham J,Moroziewicz D,Cohen SM,Hurst-Wicker KS,Cheung K,Lee DS,Divito J,Voulo M,Donovan J,Dolan K, et al. Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. J Clin Invest 2005; 115: 190312.
  • 11
    Lin SF,Yu Z,Riedl C,Woo Y,Zhang Q,Yu YA,Timiryasova T,Chen N,Shah JP,Szalay AA,Fong Y,Wong RJ. Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus. Surgery 2007; 142: 97683.
  • 12
    Yu YA,Shabahang S,Timiryasova TM,Zhang Q,Beltz R,Gentschev I,Goebel W,Szalay AA. Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins. Nature Biotechnol 2004; 22: 31320.
  • 13
    Zhang Q,Yu YA,Wang E,Chen N,Danner RL,Munson PJ,Marincola FM,Szalay AA. Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus. Cancer Res 2007; 67: 1003846.
  • 14
    Harrell MI,Iritani BM,Ruddell A. Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol 2007; 170: 77486.
  • 15
    McFadden G. Poxvirus tropism. Nat Rev Microbiol 2005; 3: 20113.
  • 16
    Smith SA,Kotwal GJ. Immune response to poxvirus infections in various animals. Crit Rev Microbiol 2002; 28: 14985.
  • 17
    Zettersten E,Shaikh L,Ramirez R,Kashani-Sabet M. Prognostic factors in primary cutaneous melanoma. Surg Clin North Am 2003; 83: 6175.
  • 18
    Thompson JF,Shaw HM. The prognosis of patients with thick primary melanomas: is regional lymph node status relevant, and does removing positive regional nodes influence outcome? Ann Surg Oncol 2002; 9: 71922.
  • 19
    Francken AB,Accortt NA,Shaw HM,Wiener M,Soong SJ,Hoekstra HJ,Thompson JF. Prognosis and determinants of outcome following locoregional or distant recurrence in patients with cutaneous melanoma. Ann Surg Oncol 2008; 15: 147684.
  • 20
    Gershenwald JE,Mansfield PF,Lee JE,Ross MI. Role for lymphatic mapping and sentinel lymph node biopsy in patients with thick (> or = 4 mm) primary melanoma. Ann Surg Oncol 2000; 7: 1605.
  • 21
    Creager AJ,Shiver SA,Shen P,Geisinger KR,Levine EA. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Cancer 2002; 94: 301622.
  • 22
    Soo V,Shen P,Pichardo R,Azzazy H,Stewart JH,Geisinger KR,Levine EA. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Ann Surg Oncol 2007; 14: 16127.
  • 23
    Shivers S,Jakub J,Pendas S,Reintgen D. Molecular staging for patients with malignant melanoma. Expert Rev Anticancer Ther 2007; 7: 166574.
  • 24
    Eisenberg DP,Adusumilli PS,Hendershott KJ,Chung S,Yu Z,Chan MK,Hezel M,Wong RJ,Fong Y. Real-time intraoperative detection of breast cancer axillary lymph node metastases using a green fluorescent protein-expressing herpes virus. Ann Surg 2006; 243: 82430.
  • 25
    Hodge JW,Abrams S,Schlom J,Kantor JA. Induction of antitumor immunity by recombinant vaccinia viruses expressing B7–1 or B7–2 costimulatory molecules. Cancer Res 1994; 54: 55525.
  • 26
    Kaufman HL,Conkright W,Divito J,Jr,Horig H,Kaleya R,Lee D,Mani S,Panicali D,Rajdev L,Ravikumar TS,Wise-Campbell S,Surhland MJ. A phase I trial of intra lesional RV-B7.1 vaccine in the treatment of malignant melanoma. Hum Gene Ther 2000; 11: 106582.