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Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial†
Article first published online: 20 OCT 2008
Published 2008 Wiley-Liss, Inc.
International Journal of Cancer
Volume 124, Issue 9, pages 2148–2151, 1 May 2009
How to Cite
Murphy, G., Cross, A. J., Sansbury, L. S., Bergen, A., Laiyemo, A. O., Albert, P. S., Wang, Z., Yu, B., Lehman, T., Kalidindi, A., Modali, R., Schatzkin, A. and Lanza, E. (2009), Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial. Int. J. Cancer, 124: 2148–2151. doi: 10.1002/ijc.24079
This article is a US Government work, and, as such, is in the public domain in the United States of America.
- Issue published online: 24 FEB 2009
- Article first published online: 20 OCT 2008
- Manuscript Accepted: 29 SEP 2008
- Manuscript Received: 25 JUL 2008
- Intramural Research Program, National Cancer Institute, NIH, Bethesda, MD
- Ireland-Northern Ireland-National Cancer Institute Cancer Consortium and the Health Research Board of Ireland
Epidemiological evidence suggests that obesity may be causally associated with colorectal cancer. Dopamine and the dopaminergic reward pathway have been implicated in drug and alcohol addiction as well as obesity. Polymorphisms within the D2 dopamine receptor gene (DRD2) have been shown to be associated with colorectal cancer risk. We investigated the association between DRD2 genotype at these loci and the risk of colorectal adenoma recurrence in the Polyp Prevention Trial. Odds ratios (OR) and 95% confidence intervals (CI) for risk of adenoma recurrence were calculated using unconditional logistic regression. Individuals with any, multiple (≥2) or advanced adenoma recurrence after 4 years were compared to those without adenoma recurrence. Variation in intake of certain dietary components according to DRD2 genotype at 3 loci (rs1799732; rs6277; rs1800497) was also investigated. The DRD2 rs1799732 CT genotype was significantly associated with all adenoma recurrence (OR: 1.30; 95% CI: 1.01, 1.69). The rs1800497 TT genotype was also associated with a significantly increased risk of advanced adenoma recurrence (OR: 2.40; 95% CI: 1.11, 5.20). The rs1799732 CT and rs1800497 TT genotypes were significantly associated with adenoma recurrence in the Polyp Prevention Trial. Increased risk of adenoma recurrence as conferred by DRD2 genotypes may be related to difference in alcohol and fat intake across genotypes. Published 2008 Wiley-Liss, Inc.