Immunoglobulin subclass levels in patients with non-Hodgkin lymphoma
Article first published online: 23 DEC 2008
Copyright © 2008 Wiley-Liss, Inc.
International Journal of Cancer
Volume 124, Issue 11, pages 2616–2620, 1 June 2009
How to Cite
Biggar, R. J., Christiansen, M., Rostgaard, K., Smedby, K. E., Adami, H.-O., Glimelius, B., Hjalgrim, H. and Melbye, M. (2009), Immunoglobulin subclass levels in patients with non-Hodgkin lymphoma. Int. J. Cancer, 124: 2616–2620. doi: 10.1002/ijc.24245
- Issue published online: 25 MAR 2009
- Article first published online: 23 DEC 2008
- Accepted manuscript online: 23 DEC 2008 12:00AM EST
- Manuscript Accepted: 28 NOV 2008
- Manuscript Received: 27 OCT 2008
- diffuse large B-cell NHL;
- follicular NHL;
- mantle cell NHL;
Allergy/atopy has been suggested to protect against non-Hodgkin lymphoma (NHL) and specific IgE levels are decreased in patients with NHL. We speculated that all immunoglobulin subclass levels might be downregulated in NHL and examined levels of IgM, IgD, IgA, IgE, IgG and IgG4 in 200 NHL patients and 200 age- and sex-matched controls. Patients with B-cell NHL of many types had consistently lower median immunoglobulin subclass levels than controls. In every subclass except IgD, about 10–15% of B-cell NHL patients had absolute levels below the 2.5 percentile of controls. Subclass levels correlated with each other and many patients had more than one significantly low level. Levels were lowest for IgG4 and IgE. Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma had especially low total IgE levels. In other B-cell NHL types, total IgE levels were decreased to a similar extent as other immunoglobulin subclasses. In conclusion, low IgE levels are only part of a more generalized loss of immunoglobulins of all subtypes in a wide variety of B-cell NHL types. Low immunoglobulin levels appear to be a consequence of B-cell NHL presence, and we speculate about molecular mechanisms that could reduce all immunoglobulin subclasses in B-cell NHL. © 2008 Wiley-Liss, Inc.