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Increased expression of fatty acid synthase in human aberrant crypt foci: Possible target for colorectal cancer prevention

  1. Kathleen E. Kearney,
  2. Thomas G. Pretlow,
  3. Theresa P. Pretlow†,*

Article first published online: 17 FEB 2009

DOI: 10.1002/ijc.24356

Issue

International Journal of Cancer

International Journal of Cancer

Volume 125, Issue 1, pages 249–252, 1 July 2009

Additional Information

How to Cite

Kearney, K. E., Pretlow, T. G. and Pretlow, T. P. (2009), Increased expression of fatty acid synthase in human aberrant crypt foci: Possible target for colorectal cancer prevention. Int. J. Cancer, 125: 249–252. doi: 10.1002/ijc.24356

Author Information

  1. Department of Pathology and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH

  1. †

    Fax: +216-368-1357.

*Department of Pathology, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106-7288, USA

  1. †

    Fax: +216-368-1357.

Publication History

  1. Issue published online: 27 APR 2009
  2. Article first published online: 17 FEB 2009
  3. Accepted manuscript online: 17 FEB 2009 12:00AM EST
  4. Manuscript Accepted: 26 JAN 2009
  5. Manuscript Received: 26 NOV 2008

Funded by

  • National Cancer Institute. Grant Numbers: CA66725, P30 CA43703

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References

  • 1
    Kuhajda FP. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 2006; 66: 5977–80.
  • 2
    Kusakabe T,Maeda M,Hoshi N,Sugino T,Watanabe K,Fukuda T,Suzuki T. Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells. J Histochem Cytochem 2000; 48: 613–22.
  • 3
    Menendez JA,Lupu R. Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells. Curr Opin Clin Nutr Metab Care 2006; 9: 346–57.
  • 4
    Weiss L,Hoffmann GE,Schreiber R,Andres H,Fuchs E,Korber E,Kolb HJ. Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe Seyler 1986; 367: 905–12.
  • 5
    Kuhajda FP. Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology. Nutrition 2000; 16: 202–8.
  • 6
    Visca P,Sebastiani V,Pizer ES,Botti C,De Carli P,Filippi S,Monaco S,Alo PL. Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma. Anticancer Res 2003; 23: 335–9.
  • 7
    Piyathilake CJ,Frost AR,Manne U,Bell WC,Weiss H,Heimburger DC,Grizzle WE. The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol 2000; 31: 1068–73.
  • 8
    Guo CB,Cui NH,Yu GY,Liu DX,Meng SC,Song Q. Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity. J Oral Maxillofac Surg 2003; 61: 909–12.
  • 9
    Krontiras H,Roye GD,Beenken SE,Myers RB,Mayo MS,Peters GE,Grizzle WE. Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue. Head Neck 1999; 21: 325–9.
    Direct Link:
  • 10
    Nemoto T,Terashima S,Kogure M,Hoshino Y,Kusakabe T,Suzuki T,Gotoh M. Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma. Pathobiology 2001; 69: 297–303.
  • 11
    Kusakabe T,Nashimoto A,Honma K,Suzuki T. Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. Histopathology 2002; 40: 71–9.
    Direct Link:
  • 12
    Innocenzi D,Alo PL,Balzani A,Sebastiani V,Silipo V,La Torre G,Ricciardi G,Bosman C,Calvieri S. Fatty acid synthase expression in melanoma. J Cutan Pathol 2003; 30: 23–8.
    Direct Link:
  • 13
    Camassei FD,Cozza R,Acquaviva A,Jenkner A,Rava L,Gareri R,Donfrancesco A,Bosman C,Vadala P,Hadjistilianou T,Boldrini R. Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness. Invest Ophthalmol Vis Sci 2003; 44: 2399–403.
  • 14
    Camassei FD,Jenkner A,Rava L,Bosman C,Francalanci P,Donfrancesco A,Alo PL,Boldrini R. Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study. Med Pediatr Oncol 2003; 40: 302–8.
    Direct Link:
  • 15
    Milgraum LZ,Witters LA,Pasternack GR,Kuhajda FP. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 1997; 3: 2115–20.
  • 16
    Siu I-M,Robinson DR,Schwartz S,Kung H-J,Pretlow TG,Petersen RB,Pretlow TP. The identification of monoclonality in human aberrant crypt foci. Cancer Res 1999; 59: 63–6.
  • 17
    Hao XP,Pretlow TG,Rao JS,Pretlow TP. b-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res 2001; 61: 8085–8.
  • 18
    Pretlow TP,Pretlow TG. Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer? Biochim Biophys Acta 2005; 1756: 83–96.
  • 19
    Giovannucci E. Insulin, insulin-like growth factors and colon cancer: A review of the evidence. J Nutr 2001; 131: 3109S–20S.
  • 20
    Visca P,Alo PL,Del Nonno F,Botti C,Trombetta G,Marandino F,Filippi S,Di Tondo U,Donnorso RP. Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. Clin Cancer Res 1999; 5: 4111–18.
  • 21
    Visca P,Sebastiani V,Botti C,Diodoro MG,Lasagni RP,Romagnoli F,Brenna A,De Joannon BC,Donnorso RP,Lombardi G,Alo PL. Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. Anticancer Res 2004; 24: 4169–73.
  • 22
    Rashid A,Pizer ES,Moga M,Milgraum LZ,Zahurak M,Pasternack GR,Kuhajda FP,Hamilton SR. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol 1997; 150: 201–8.
  • 23
    Zhou W,Han WF,Landree LE,Thupari JN,Pinn ML,Bililign T,Kim EK,Vadlamudi A,Medghalchi SM,El Meskini R,Ronnett GV,Townsend CA, et al. Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res 2007; 67: 2964–71.
  • 24
    Lu S,Archer MC. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. Carcinogenesis 2005; 26: 153–7.
  • 25
    Xiao R,Su Y,Simmen RC,Simmen FA. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol 2008; 294: G868–76.
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