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Carcinogenesis
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A maternal high-fat diet during pregnancy in rats results in a greater risk of carcinogen-induced mammary tumors in the female offspring than exposure to a high-fat diet in postnatal life
Article first published online: 2 APR 2009
DOI: 10.1002/ijc.24464
Copyright © 2009 UICC
Additional Information
How to Cite
Lo, C.-Y., Hsieh, P.-H., Chen, H.-F. and Su, H.-M. (2009), A maternal high-fat diet during pregnancy in rats results in a greater risk of carcinogen-induced mammary tumors in the female offspring than exposure to a high-fat diet in postnatal life. International Journal of Cancer, 125: 767–773. doi: 10.1002/ijc.24464
Publication History
- Issue published online: 11 JUN 2009
- Article first published online: 2 APR 2009
- Manuscript Accepted: 26 FEB 2009
- Manuscript Received: 4 NOV 2008
Funded by
- National Science Council of Taiwan. Grant Numbers: NSC91-2320-B-002-106, NSC92-2320-B-002-065, NSC93-2320-B-002-026
- Department of Health. Grant Number: DOH-94-TD-F-113-031
- Abstract
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Keywords:
- breast cancer;
- high-fat diet;
- life stage;
- arachidonic acid
Abstract
The association between a high-fat diet and breast cancer risk is controversial. We hypothesized that the exposure of rats to a high-fat diet in uterovia the maternal diet would result in a greater risk of carcinogen-induced mammary tumors than high-fat diet exposure in postnatal life. Rats were exposed to a high-fat diet with 40% of the energy source as safflower oil in utero (In utero group), at postnatal days 30–50 (Puberty group), postnatal days 150–170 (Adult group), postnatal days 1–230 (Postnatal group) or for their whole life from in utero (Whole group). Chow diet-fed rats were used as the Nonexposure group. Mammary tumor incidence was significantly higher in the In utero (60%), Postnatal (61%) and Whole (91%) groups than in the Nonexposure group (32%), but there was no significant difference between the Puberty (44%), Adult (44%) and Nonexposure groups. Arachidonic acid levels were 10 times higher in mammary tumor tissue than in the normal mammary gland across all groups and were positively correlated with tumor weight. We conclude that the timing, but not the duration, of high-fat diet exposure makes rats more susceptible to carcinogen-induced mammary tumors and that exposure in utero to a maternal high-fat diet during pregnancy is more important in increasing the risk of mammary tumors in the female offspring than exposure of the offspring to the same high-fat diet later in life. © 2009 UICC