Short Report
You have full text access to this OnlineOpen article
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease
Article first published online: 16 JUN 2009
DOI: 10.1002/ijc.24650
Copyright © 2009 UICC
Additional Information
How to Cite
Calvisi, D. F., Pinna, F., Ladu, S., Muroni, M. R., Frau, M., Demartis, I., Tomasi, M. L., Sini, M., Simile, M. M., Seddaiu, M. A., Feo, F. and Pascale, R. M. (2010), The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Int. J. Cancer, 126: 1275–1281. doi: 10.1002/ijc.24650
Publication History
- Issue published online: 27 DEC 2009
- Article first published online: 16 JUN 2009
- Accepted manuscript online: 16 JUN 2009 12:00AM EST
- Manuscript Accepted: 29 MAY 2009
- Manuscript Received: 8 APR 2009
Funded by
- Associazione Italiana Ricerche sul Cancro, Ministero Università e Ricerca
References
- 1, . Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002; 31: 339–46.
- 2, . Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006; 6: 674–8.
- 3, , , , , , . Hepatocellular carcinoma as a complex polygenic disease. Interpretative analysis of recent developments on genetic predisposition. BBA Cancer Rev 2006; 1765: 126–47.
- 4, . Familial risks of cancer as a guide to gene identification and mode of inheritance. Int J Cancer 2004; 110: 291–4.
- 5, , , , , , , , , , . Role of HSP90. CDC37, and CRM1 as modulators of. P16(INK4A) activity in rat liver carcinogenesis and human liver cancer. Hepatology 2005; 42: 1310–19.
- 6, , , , , , , , , . Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis. Hepatology 2002; 35: 1341–50.
- 7, , , , , , , , , , , , et al. Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control. Int J Cancer 2008; 123: 2057–64.
- 8, , , , , , , , , , , , et al. Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated-kinase-mediated control of growth in human hepatocellular carcinoma. Cancer Res 2008; 68: 4192–200.
- 9, , , , , , , , . Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol 2005; 25: 10875–94.
- 10, , , , , , , , , , , , et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 2000; 19: 2069–81.
- 11, , , , , . Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition. Oncogene 2008; 27: 3176–85.
- 12, , . Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol 1997; 88: 595–618.
- 13, . CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501–12.
- 14, , , , , . Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 2003; 163: 1371–8.
- 15, , , , , , , . CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma. Int J Cancer 2008; 123: 998–1004.
- 16, , , , , , . p53 and p21WAF1/CIP1 in hepatitis B virus related hepatocarcinogenesis. Hepatogastroenterology 2003; 50: 1292–6.
- 17, . p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis. Med Mol Morphol 2006; 39: 169–75.
- 18, . Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysis. Hum Pathol 2001; 32: 778–84.
- 19, . Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 2008; 8: 438–49.
- 20, , , , , , , , , , , . Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. Gut 2009; 58: 679–87.
- 21, . F-box protein Skp2: a novel transcriptional target of E2F. Oncogene 2006; 25: 2615–27.
- 22, , , , , . Segregation analysis of hepatocellular carcinoma in a moderately high-incidence area of East China. World J Gastroenterol 2003; 9: 2428–32.
- 23, , , , . Family history and the risk of liver, gallbladder, and pancreatic cancer. Cancer. Epidemiol. Biomarkers Prev 1994; 3: 209–12.
- 24, , , , , , , , , . Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives. J Natl Cancer Inst 2000; 92: 1159–64.

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
