SEARCH

SEARCH BY CITATION

References

  • 1
    Dooley CP,Cohen H,Fitzgibbons PL,Bauer M,Appleman MD,Perez-Perez GI,Blaser MJ. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Eng J Med 1989; 321: 15626.
  • 2
    Danesh J. Helicobacter pylori infection and gastric cancer: systematic review of the epidemiological studies. Aliment Pharmacol Ther 1999; 13: 8516.
  • 3
    Parsonnet J,Friedman GD,Orentreich N,Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997; 40: 297301.
  • 4
    Kuipers EJ,Perez-Perez GI,Meuwissen SG,Blaser MJ. Helicobacter pylori and atrophic gastritis: importance of the cagA status. JNatl Cancer Inst 1995; 87: 177780.
  • 5
    Covacci A,Telford JL,Del Giudice G,Parsonnet J,Rappuoli R. Helicobacter pylori virulence and genetic geography. Science 1999; 284: 132833.
  • 6
    Censini S,Lange C,Xiang Z,Crabtree JE,Ghiara P,Borodovsky M,Rappuoli R,Covacci A. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996; 93: 1464853.
  • 7
    Covacci A,Falkow S,Berg DE,Rappuoli R. Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori?. Trends Microbiol 1997; 5: 2058.
  • 8
    Segal ED,Falkow S,Tompkins LS. Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins. Proc Natl Acad Sci USA 1996; 93: 125964.
  • 9
    Selbach M,Moese S,Hauck CR,Meyer TF,Backert S. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 2002; 277: 67758.
  • 10
    Stein M,Bagnoli F,Halenbeck R,Rappuoli R,Fantl WJ,Covacci A. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 2002; 43: 97180.
  • 11
    Poppe M,Feller SM,Römer G,Wessler S. Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell mortility. Oncogene 2007; 26: 346272.
  • 12
    Tammer I,Brandt S,Hartig R,Köing W,Backert S. Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology 2007; 132: 130919.
  • 13
    Higashi H,Tsutsumi R,Muto S,Sugiyama T,Azuma T,Asaka M,Hatakeyama M. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 2002; 295: 6836.
  • 14
    Tartaglia M,Niemeyer CM,Fragale A,Song X,Buechner J,Jung A,Hahlen K,Hasle H,Licht JD,Gelb BD. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet 2003; 34: 14850.
  • 15
    Loh ML,Vattikuti S,Schubbert S,Reynolds MG,Carlson E,Lieuw KH,Cheng JW,Lee CM,Stokoe D,Bonifas JM,Curtiss NP,Gotlib J, et al. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood 2004; 103: 232531.
  • 16
    Tartaglia M,Gelb BD. Germ-line and somatic PTPN11 mutations in human disease. Eur J Med Genet 2005; 48: 8196.
  • 17
    Saadat I,Higashi H,Obuse C,Umeda M,Murata-Kamiya N,Saito Y,Lu H,Ohnishi N,Azuma T,Suzuki A,Ohno S,Hatakeyama M. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 2007; 447: 3303.
  • 18
    Tsutsumi R,Higashi H,Higuchi M,Okada M,Hatakeyama M. Attenuation of Helicobacter pylori CagA·SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem 2003; 278: 366470.
  • 19
    Churin Y,Al-Ghoul L,Kepp O,Meyer TF,Birchmeier W,Naumann M. Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 2003; 161: 24955.
  • 20
    Mimuro H,Suzuki T,Tanaka J,Asahi M,Haas R,Sasakawa C. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 2002; 10: 74555.
  • 21
    Suzuki M,Mimuro H,Suzuki T,Park M,Yamamoto T,Sasakawa C. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med 2005; 202: 123547.
  • 22
    Murata-Kamiya N,Kurashima Y,Teishikata Y,Yamahashi Y,Saito Y,Higashi H,Aburatani H,Akiyama T,Peek RM Jr,Azuma T,Hatakeyama M. Helicobacter pylori CagA·interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cell. Oncogene 2007; 26: 461726.
  • 23
    Yamaoka Y,Osato MS,Sepulveda AR,Gutierrez O,Figura N,Kim JG,Kodama T,Kashima K,Graham DY. Molecular epidemiology of Helicobacter pylori: separation of H. pylori from East Asian and non-Asian countries. Epidemiol Infect 2000; 124: 916.
  • 24
    Alm RA,Ling LS,Moir DT,King BL,Brown ED,Doig PC,Smith DR,Noonan B,Guild BC,deJonge BL,Carmel G,Tummino PJ, et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 1999; 397: 17680.
  • 25
    Kersulyte D,Mukhopadhyay AK,Velapatino B,Su W,Pan Z,Garcia C,Hernandez V,Valdez Y,Mistry RS,Gilman RH,Yuan Y,Gao H, et al. Differences in genotypes of Helicobacter pylori from different human populations. J Bacteriol 2000; 182: 32108.
  • 26
    Higashi H,Tsutsumi R,Fujita A,Yamazaki S,Asaka M,Azuma T,Hatakeyama M. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci USA 2002; 99: 1442833.
  • 27
    Azuma T,Yamazaki S,Yamakawa A,Ohtani M,Muramatsu A,Suto H,Ito Y,Dojo M,Yamazaki Y,Kuriyama M,Keida Y,Higashi H, et al. Association between diversity in the Src Homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J Infect Dis 2004; 189: 8207.
  • 28
    Basso D,Zambon CF,Letley DP,Stranges A,Marchet A,Rhead JL,Schiavon S,Guariso G,Ceroti M,Nitti D,Rugge M,Plebani M, et al. Clinical relevance of Helicobacter pyloricagA and vacA gene polymorphism. Gastroenterology 2008; 135: 919.
  • 29
    Ohnishi N,Yuasa H,Tanaka S,Sawa H,Miura M,Matsui A,Higashi H,Musashi M,Iwabuchi K,Suzuki M,Yamada G,Azuma T, et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci USA 2008; 105: 10038.
  • 30
    Araki K,Araki M,Miyazaki J,Vassalli P. Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc Natl Acad Sci USA 1995; 92: 1604.
  • 31
    Peek RM,Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2002; 2: 2837.
  • 32
    Parsonnet J,Hansen S,Rodriguez L,Gelb AB,Warnke RA,Jellum E,Orentreich N,Vogelman JH,Friedman GD. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994; 330: 126771.
  • 33
    Moser AR,Pitot HC,Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990; 256: 66870.
  • 34
    Oshima M,Oshima H,Kitagawa K,Kobayashi M,Itakura C,Taketo M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci USA 1995; 92: 44826.
  • 35
    Quesada CF,Kimata H,Mori M,Nishimura M,Tsuneyoshi T,Baba S. Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice. Jpn J Cancer Res 1998; 89: 3926.
  • 36
    Naito M,Yamazaki T,Tsutsumi R,Higashi H,Onoe K,Yamazaki S,Azuma T,Hatakeyama M. Influence of EPIYA-Repeat Polymorphism on the Phosphorylation-Dependent Biological Activity of Helicobacter pylori CagA. Gastroenterology 2006; 130: 118190.
  • 37
    Nakajima A,Matsuhashi N,Yazaki Y,Oka T,Sugano K. Details of hyperplastic polyps of the stomach shrinking after anti-Helicobacter pylori therapy. J Gastroenterol 2000; 35: 3725.
  • 38
    Veereman Wauters G,Ferrell L,Ostroff JW,Heyman MB. Hyperplastic gastric polyps associated with persistent Helicobacter pyloriinfection and active gastritis. Am J Gatroenterol 1990; 85: 13957.
  • 39
    Huang JQ,Sridhar S,Chen Y,Hunt RH. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 1998; 114: 116979.
  • 40
    Kuipers EJ. Review article: exploing the link between Helicobacter pylori and gastric cancer. Aliment Pharmacol Ther 1999; Suppl 1: 311.
  • 41
    Araki T,Mohi MG,Ismat FA,Bronson RT,Williams IR,Kutok JL,Yang W,Pao LI,Gilliland DG,Epstein JA,Neel BG. Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med 2004; 10: 84957.
  • 42
    Fox JG,Sheppard BJ,Dangler CA,Whary MT,Ihrig M,Wang TC. Germ-Line p53-targeted disruption inhibits Helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses. Cancer Res 2002; 62: 696702.
  • 43
    Wang TC,Dangler CA,Chen D,Goldenring JR,Koh T,Raychowdhury R,Coffey RJ,Ito S,Varro A,Dockray GJ,Fox JG. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 2000; 118: 3647.