Cancer Cell Biology
Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU
Article first published online: 20 JUL 2009
Copyright © 2009 UICC
International Journal of Cancer
Volume 126, Issue 3, pages 631–639, 1 February 2010
How to Cite
Liu, G., Hu, X. and Chakrabarty, S. (2010), Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU. Int. J. Cancer, 126: 631–639. doi: 10.1002/ijc.24762
- Issue published online: 8 DEC 2009
- Article first published online: 20 JUL 2009
- Accepted manuscript online: 20 JUL 2009 12:00AM EST
- Manuscript Accepted: 13 JUL 2009
- Manuscript Received: 6 APR 2009
- 1Serum 25-hydroxyvitamin D, dietary calcium intake, and distal colorectal adenoma risk. Nutr Cancer 2001; 39: 35–41., , , , , , , , .
- 2Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage. Carcinogenesis 2001; 22: 1429–35., , , , , , , , .
- 3Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst 2003; 95: 1765–71., , , , , , .
- 4Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 1980; 9: 227–31., .
- 5A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst 2007; 99: 1120–9., , , , , .
- 6Calcium sensing receptor in human colon carcinoma: interaction with Ca2+ and 1,25-dihydroxyvitamin D3. Cancer Res 2005; 65: 493–8., , , , , .
- 7SNAIL vs vitamin D receptor expression in colon cancer: therapeutics implications. Br J Cancer 2005; 92: 985–9., .
- 8Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. J Cell Biol 2001; 154: 369–87., , , , , , , , , , .
- 9The extracellular calcium-sensing receptor: its role in health and disease. Annu Rev Med 1998; 49: 15–29., , .
- 10Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil. Mol Carcinog 2009; 48: 202–11., , , .
- 11Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res 2003; 63: 67–71., , , .
- 12Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma. Br J Cancer 2005; 93: 1364–71., , , , , , , .
- 13Regulation of E-cadherin and beta-catenin by Ca2+ in colon carcinoma is dependent on calcium-sensing receptor expression and function. Int J Cancer 2007; 121: 1455–62., , , , , .
- 14Thymidylate synthase pharmacogenetics. Invest New Drugs 2005; 23: 533–7..
- 15Thymidylate synthase inhibitors as anticancer agents: from bench to bedside. Cancer Chemother Pharmacol 2003; 52: S80–9., , , .
- 16Thymidylate synthase: a critical target for cancer chemotherapy. Clin Colorectal Cancer 2002; 1: 220–9., , .
- 17Systemic treatment of colorectal cancer. Gastroenterology 2008; 134: 1296–310., .
- 18Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. Cancer Res 2007; 67: 4989–95., , , , .
- 19Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998; 396: 580–4., , , , , , .
- 20Cloning and characterization of two promoters for the human calcium-sensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas. J Biol Chem 2000; 272: 7553–7., , , , , , .
- 21Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem 2002; 277: 30337–50., .
- 22Identification and functional characterization of a novel mutation in the calcium-sensing receptor gene in familial hypocalciuric hypercalcemia: modulation of clinical severity by vitamin D status. J Clin Endocrinol Metab 2007; 92: 2616–23., , , , , .
- 23Induction of survivin expression by taxol (paclitaxel) is an early event, which is independent of taxol-mediated G2/M arrest. J Biol Chem 2004; 279: 15196–203., , , .
- 24A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 2003; 63: 2898–904., , , , , , .
- 25A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 1987; 47: 3239–45., , , , , , .
- 26Calcium sensing receptor down-regulates malignant cell behavior and promotes chemosensitivity in human breast cancer cells. Cell Calcium 2009; 45: 216–25., , .
- 27Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Res 2001; 61: 5749–56., , , , , .
- 28Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. Cancer Res 2001; 61: 565–9., , , , , , , .
- 29Vitamin D. Am J Physiol 1999; 277( 2 Pt 2): F157–75. Review., , .
- 30Differential regulation of survivin expression and apoptosis by vitamin D3 compounds in two isogenic MCF-7 breast cancer cell sublines. Oncogene 2005; 24: 1385–95., , , , , , , .
- 31Anti-tumor effect of vitamin A and D on head and neck squamous cell carcinoma. Auris Nasus Larynx 2003; 30: 403–12., , , , , , .
- 32Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 2006; 354: 684–96., , , , , , , , , , , , et al.
- 33In colorectal carcinoma patients, serum vitamin D levels vary according to stage of the carcinoma. Cancer 1999; 86: 391–7., , , , , , .