Fax: +81-76-234-4262
Cancer Cell Biology
You have full text access to this OnlineOpen article
The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion†
Article first published online: 2 SEP 2009
DOI: 10.1002/ijc.24849
Copyright © 2009 UICC
Additional Information
How to Cite
Nakada, M., Anderson, E. M., Demuth, T., Nakada, S., Reavie, L. B., Drake, K. L., Hoelzinger, D. B. and Berens, M. E. (2010), The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion. Int. J. Cancer, 126: 1155–1165. doi: 10.1002/ijc.24849
- †
M. E. Berens holds stock in the company that provided cell migration assay. The other authors disclosed no potential conflicts of interest
Publication History
- Issue published online: 27 DEC 2009
- Article first published online: 2 SEP 2009
- Accepted manuscript online: 2 SEP 2009 12:00AM EST
- Manuscript Accepted: 11 AUG 2009
- Manuscript Received: 20 MAR 2009
Funded by
- NIH. Grant Number: NS042262
- Ministry of Education, Culture, Sports, Science and Technology. Grant Numbers: B-19790992, A-21689038
- Japan Society for the Promotion of Science, Foundation for Promotion of Cancer Research
- Japan Brain Foundation
References
- 1, , , . Cost of migration: invasion of malignant gliomas and implications for treatment. J Clin Oncol 2003; 21: 1624–36.
- 2, . Molecular mechanisms of glioma cell migration and invasion. J Neurooncol 2004; 70: 217–28.
- 3, , , , , . Molecular targets of glioma invasion. Cell Mol Life Sci 2007; 64: 458–78.
- 4, . Overcoming therapeutic resistance in malignant gliomas: current practices and future directions. Cancer Treat Res 2008; 139: 173–89.
- 5, , . Therapeutic strategies for inhibiting invasion in glioblastoma. Expert Rev Neurother 2009; 9: 519–34.
- 6, , , , , , , , . Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia 2005; 7: 7–16.
- 7, , , , , , , , , . MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Mol Cancer Ther 2007; 6: 1212–22.
- 8, , , , , , , , , , , , et al. Glioma cells on the run—the migratory transcriptome of 10 human glioma cell lines. BMC Genomics 2008; 9: 54.
- 9, . Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol 2002; 3: 475–86.
- 10. Eph-ephrin bidirectional signaling in physiology and disease. Cell 2008; 133: 38–52.
- 11, . The Eph receptor/ephrin system: an emerging player in the invasion game. Curr Issues Mol Biol 2008; 10: 61–6.
- 12, , , , , , . The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res 2004; 64: 3179–85.
- 13, , , , . EphB2/R-ras signaling regulates glioma cell adhesion. Growth, and invasion. Am J Pathol 2005; 167: 565–76.
- 14, , , , . Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. Cancer Res 2006; 66: 8492–500.
- 15, , , , , , . The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002; 61: 215–25; discussion 26–9.
- 16, , , , , . Cell migration and invasion assays. Methods 2005; 37: 208–15.
- 17, . Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment. Neurosurg Clin N Am 2007; 18: 39–58, viii.
- 18, . Targeted molecular therapy of GBM. Brain Pathol 2003; 13: 52–61.
- 19, , , , . Identification of secreted proteins regulated by cAMP in glioblastoma cells using glycopeptide capture and label-free quantification. Proteomics 2009; 9: 535–49.
- 20, , , . EPH receptors in cancer. Histol Histopathol 2008; 23: 1011–23.
- 21, . Eph-ephrin signalling in adult tissues and cancer. Curr Opin Cell Biol 2008; 20: 194–200.
- 22, , . Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression. Exp Cell Res 2006; 312: 642–50.
- 23, , , , , , , , , . Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. Cancer Res 1994; 54: 3645–50.
- 24, , , , , , , . Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. Clin Cancer Res 1998; 4: 791–7.
- 25, , , , , , , . High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high. Trk. A expression in human neuroblastomas. Clin Cancer Res 1999; 5: 1491–6.
- 26, , , , , . Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Mol Cell Neurosci 1996; 8: 199–209.
- 27, , , , . Coexpression of EphB4 and ephrin-B2 in tumour advancement of ovarian cancers. Br J Cancer 2008; 98: 845–51.
- 28, , , , , . The significance of EphB4 and Ephrin-B2 expression and survival in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2008; 134: 985–91.
- 29, , , , , , , , , , , . Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am J Pathol 2006; 169: 279–93.
- 30, , , , , , , . Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma. Dig Liver Dis 2007; 39: 725–32.
- 31, , , , , , . Coexpression of ephrin-B2 and their receptors in colon carcinoma. Cancer 2002; 94: 934–9.
- 32, , , , . Overexpression of ephrin-B2 and EphB4 in tumor advancement of uterine endometrial cancers. Ann Oncol 2007; 18: 485–90.
- 33, , . Rac-dependent trans-endocytosis of ephrin-B2 regulates Eph-ephrin contact repulsion. Nat Cell Biol 2003; 5: 879–88.
- 34. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res 2007; 13: 1362–6.
- 35, , , , , , . Ephrin-B1 signals from the cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad Sci U S A 2007; 104: 17305–10.
- 36, . Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 2008; 6: 675–84.
- 37, , , . The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells. J Cell Sci 2007; 120: 2179–89.

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
