Cancer Cell Biology
BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer
Version of Record online: 26 AUG 2009
Copyright © 2009 UICC
International Journal of Cancer
Volume 126, Issue 7, pages 1596–1610, 1 April 2010
How to Cite
Naderi, A., Liu, J. and Bennett, I. C. (2010), BEX2 regulates mitochondrial apoptosis and G1 cell cycle in breast cancer. Int. J. Cancer, 126: 1596–1610. doi: 10.1002/ijc.24866
- Issue online: 28 JAN 2010
- Version of Record online: 26 AUG 2009
- Manuscript Accepted: 18 AUG 2009
- Manuscript Received: 3 MAY 2009
- The University of Queensland
- 1Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities. J Biol Chem 2008; 104: 1124–49., , .
- 2Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004; 23: 2934–49., , , , .
- 3Changes in the apoptotic and survival signaling in cancer cells and their potential therapeutic implications. Cancer Drug Targets 2004; 4: 147–63., , .
- 4Mitochondrial ceramide and the induction of apoptosis. Bioenerg Biomembr 2008; 37: 143–53..
- 5Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol 2008; 181: 335–50., , .
- 6Ceramide in the eukaryotic stress response. Trends Cell Biol 2000; 10: 73–80., .
- 7Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem 2001; 276: 13606–14., , , , , , .
- 8Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem 1997; 272: 11369–77., , , , .
- 9Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J Biol Chem 2002; 277: 26796–803., , .
- 10Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 1995; 182: 367–77., , , , , , , , , .
- 11Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. FEBS Lett 1997; 400: 15–8., , .
- 12Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL. J Biol Chem 1997; 272: 9868–76., , , , .
- 13Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore. J Biol Chem 1999; 274: 31734–9., , , , , .
- 14Nerve growth factor stimulates proliferation and survival of human breast cancer cells through 2 distinct signaling pathways. J Biol Chem 2001; 276: 17864–70., , , , , , , , , .
- 15Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells. J Biol Chem 2003; 278: 16952–6., , , , .
- 16Ceramide triggers an NF-kappaB-dependent survival pathway through calpain. Cell Death Differ 2005; 12: 512–22., , , .
- 17Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis. J Biol Chem 2000; 275: 13297–306., , .
- 18Induction of p53-independent p21 during ceramide-induced G1 arrest in human hepatocarcinoma cells. Biochem Cell Biol 2000; 78: 127–35., , , .
- 19Mechanisms involved in cermaide-induced cell cycle arresit in human hepatocarcinoma cells. World J Gastroenterol 2007; 13: 1129–34., , , .
- 20BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. Cancer Res 2007; 67: 6725–36., , , , , , .
- 21CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest 2007; 117: 3753–64., , , , , , , .
- 22Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells. Br J Cancer 2002; 87: 909–17., , , .
- 23cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cells. J Biol Chem 1996; 271: 31166–71., .
- 24A gene-expression signature to predict survival in breast cancer across independent data sets. Oncogene 2007; 26: 1507–16., , , , , , , , , , .
- 25Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat. Hepatology 1997; 25: 958–63., , , .
- 26Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J Biol Chem 1999; 274: 20296–300., , , , .
- 27Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway. Mol Cell Neurosci 2003; 22: 365–82., , , .
- 28Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia 2001; 15: 515–22., , .
- 29Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell 1999; 3: 413–22., , , , , , , .
- 30Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding. Blood 2009; 113: 422–8., , .
- 31Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells. Oncogene 2000; 19: 3508–20., , , , , , , .
- 32Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. J Biol Chem 2005; 280: 23758–65., , , , , , , , , .
- 33NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 1999; 19: 5923–9., , , .
- 34Expression of the NF-kappaB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively. J Pathol 2005; 206: 123–34., , , , , , , , , , , , et al.
- 35The nuclear transcription factor kB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant chemotherapy in human breast cancer. Clin Cancer Res 2005; 11: 8398–402., , , , , , , , , , .
- 36Involvement of p27(kip1) in ceramide-mediated apoptosis in HL-60 cells. Cancer Lett 2000; 151: 39–48., , , , , , , .
- 37Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D. Oncogene 2006; 25: 7305–10., , , , .
- 38Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome. Cancer Res 2006; 66: 1040–51., .
- 39Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferation. J Biol Chem 2008; 105: 913–21., , , .
- 40Loss of cyclin A and G1-cell cycle arrest are a prerequisite of ceramide-induced toxicity in human arterial endothelial cells. Cardiovasc Res 2001; 50: 97–107., , , , , .
- 41BAD enables ceramide to signal apoptosis via Ras and Raf-1. J Biol Chem 1998; 273: 30419–26., , , , .
- 42Mitochondrial protein phosphatase 2A regulates cell death induced by simulated ischemia in kidney NRK-52E cells. Cell Cycle 2007; 6: 2377–85., , , , , .
- 43PP2A fulfills its promises as tumor suppressor: which subunits are important? Cancer Cell 2004; 5: 105–6., .
- 44Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry 2003; 42: 4277–91., , , , , , , , , , , , et al.
- 45Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements. FASEB J 2001; 15: 403–15., , , , , , , , , , , .
- 46Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther 2007; 15: 1259–63., , , , , , , , , , , , et al.