Cancer Cell Biology
MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model
Version of Record online: 26 AUG 2009
Copyright © 2009 UICC
International Journal of Cancer
Volume 126, Issue 7, pages 1621–1629, 1 April 2010
How to Cite
Fu, J.-F., Hsu, C.-L. and Shih, L.-Y. (2010), MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model. Int. J. Cancer, 126: 1621–1629. doi: 10.1002/ijc.24867
- Issue online: 28 JAN 2010
- Version of Record online: 26 AUG 2009
- Manuscript Accepted: 20 AUG 2009
- Manuscript Received: 4 AUG 2009
- National Science Council, Taiwan. Grant Numbers: NSC 95-2320-B-182A-015, NSC 94-2320-B-182A-019
- Chang Gung Memorial Hospital, Taiwan. Grant Number: CMRPG340171∼3
- National Health Research Institute, Taiwan. Grant Number: NHRI-Ex96-9434SI
- 1HeimS, MitelmanF, eds. Cancer cytogenetics: chromosomal and molecular aberrations of tumor cells, 2nd edn. New York: Wiley, 1995.
- 2MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007; 7: 823–33., .
- 3Cytogenetic and molecular analysis of chromosome 11q23 abnormalities in leukaemia. Ballieres Clin Haematol 1992; 5: 881–95..
- 4Southern blot analysis of ALL-1 rearrangements at chromosome 11q23 in acute leukemia. Cancer Res 1993; 53: 3800–3., , , , , , , , , , .
- 5Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes. J Clin Invest 1994; 93: 429–37., , , , , , , , .
- 6Prevalence and clinical correlations of MLL gene rearrangements in AML-M4/5. Blood 1994; 84: 3776–80., , , , , , , .
- 7Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis. Cancer Res 1995; 55: 4220–4., , , , , , , , , , .
- 8The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 on to the HRX gene. Blood 1995; 86: 2073–6., , , , , , .
- 9Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement. Leukemia 2006; 20: 218–23., , , , , , , , , , .
- 10The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood 2002; 99: 3780–5., , , , , .
- 11MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol 2002; 22: 6542–52., .
- 12Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 2002; 100: 238–45., , , , , , , , , , , , et al.
- 13A new cytokine-dependent monoblastic cell line with t(9;11)(p22;q23) differentiates to macrophages with macrophage colony-stimulating factor (M-CSF) and to osteoclast-like cells with M-CSF and interleukin-4. Blood 1998; 91: 4543–53., , , , , , , , .
- 14MLL-AF9 oncogene expression affects cell growth but not terminal differentiation and is downregulated during monocyte-macrophage maturation in AML-M5 THP-1 cells. Oncogene 2003; 22: 8671–6., , , , , , , , , , .
- 15Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J 1997; 16: 4226–37., , , .
- 16MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation. Cancer Res 2001; 61: 6480–6., , , , , .
- 17Continuous MLL-ENL expression is necessary to establish a “Hox Code” and maintain immortalization of hematopoietic progenitor cells. Cancer Res 2005; 65: 9245–52., , , , , , , , , , .
- 18Regulation of myeloid development and function by colony stimulating factors. Dev Comp Immunol 2004; 28: 509–54., , .
- 19Tumor necrosis factor (TNF)-alpha but not TNF-beta induces secretion of colony stimulating factor for macrophages (CSF-1) by human monocytes. Blood 1987; 70: 1700–3., , , , .
- 20Enhancement of release of granulocyte- and granulocyte-macrophage colony-stimulating factors from phytohemagglutinin-stimulated sorted subsets of human T lymphocytes by recombinant human tumor necrosis factor-alpha. Synergism with recombinant human IFN-gamma. J Immunol 1988; 141: 201–7., , , , , , , .
- 21Recombinant human TNF alpha stimulates production of granulocyte colony-stimulating factor. Blood 1987; 70: 55–9., , , , , .
- 22Additive effects of interleukin 1 and tumour necrosis factor-alpha on the accumulation of the three granulocyte and macrophage colony-stimulating factor mRNAs in human endothelial cells. EMBO J 1987; 6: 2261–5., , , .
- 23Interleukin 1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors. Mechanism for the hematopoietic response to inflammation. J Clin Invest 1988; 81: 92–7., , .
- 24Interferon-gamma enhances the LPS-induced G-CSF gene expression in human adherent monocytes, which is regulated at transcriptional and posttranscriptional levels. Exp Hematol 1993; 21: 785–90., , , , .
- 25Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis. J Clin Invest 2005; 115: 919–29., , , , , , , , .
- 26The MLL-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. EMBO J 1999; 18: 3564–74., , , , , , , .
- 27Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 2005; 24: 368–81., , , , , , , , , , , , et al.
- 28Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia. EMBO J 2000; 19: 4655–64., , , .