Tel.: (216) 368-6162, Fax: 216-368-0213
Carcinogenesis
You have full text access to this OnlineOpen article
Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells
Article first published online: 23 OCT 2009
DOI: 10.1002/ijc.24988
Copyright © 2009 UICC
Additional Information
How to Cite
Pandey, M., Shukla, S. and Gupta, S. (2010), Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. Int. J. Cancer, 126: 2520–2533. doi: 10.1002/ijc.24988
Publication History
- Issue published online: 23 MAR 2010
- Article first published online: 23 OCT 2009
- Manuscript Accepted: 13 OCT 2009
- Manuscript Revised: 8 SEP 2009
- Manuscript Received: 6 AUG 2009
Funded by
- United States Public Health Services. Grant Numbers: RO1 CA115491, R21 CA109424
References
- 1, , , , , , , , , , , , et al. GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells. Am J Pathol 2001; 159: 1815–26.
- 2, , . Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells. Cancer Res 2001; 61: 4820–6.
- 3, , , , . Pi-class glutathione S-transferase: regulation and function. Chem Biol Interact 1998; 111–112:69–82.
- 4, , , . Glutathione-S-transferase family of enzymes. Mutat Res 2001; 482: 21–6.
- 5, , , , , , , , . Polymorphisms of glutathione-S-transferase genes (GSTP1, GSTM1 and GSTT1) and prostate-cancer risk. Int J Cancer 2001; 95: 152–5.Direct Link:
- 6, , , , , . Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc Natl Acad Sci USA 1998; 95: 5275–80.
- 7, , , , , . Glutathione-S-transferase pi amplification is associated with cisplatin resistance in head and neck squamous cell carcinoma cell lines and primary tumors. Cancer Res 2003; 63: 8097–102.
- 8, , , . Expression of multidrug resistance 1 and glutathione-S-transferase-Pi protein in nasopharyngeal carcinoma. Hum Pathol 2001; 32: 1240–4.
- 9, , . Sp1-mediated transcriptional activation of the human Pi class glutathione-S-transferase promoter. J Biol Chem 1996; 271: 1054–60.
- 10, , , , , . Detailed methylation analysis of the glutathione-S-transferase pi (GSTP1) gene in prostate cancer. Oncogene 1999; 18: 1313–24.
- 11, , , , , . Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells. Prostate 2002; 51: 225–30.Direct Link:
- 12, , , , , . GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer. J Cell Biochem 2004; 91: 540–52.Direct Link:
- 13, , , , , , . Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. Am J Pathol 2003; 163: 923–33.
- 14, , . DNA methylation of GSTP1 as biomarker in diagnosis of prostate cancer. Urology 2007; 69: 11–6.
- 15, . Epigenetics and complex disease: from etiology to new therapeutics. Annu Rev Pharmacol Toxicol 2008; 48: 257–76.
- 16, . Mammalian DNA methyltransferases. Acta Biochim Pol 2006; 53: 245–56.
- 17, , , , , , . Abnormal DNA methylation, epigenetics, and prostate cancer. Front Biosci 2007; 12: 4254–66.
- 18, , , , , , . DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Cancer Res 2006; 66: 11659–67.
- 19, . DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst 2005; 97: 1498–506.
- 20, , , , , . Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. Cancer Res 2006; 66: 385–92.
- 21, , . Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci USA 1994; 91: 11797–801.
- 22, , , , , , , , . Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer. Oncogene 2007; 26: 6560–5.
- 23, , , , , , . DNA methylation and immunohistochemical analysis of the S100A4 calcium binding protein in human prostate cancer. Prostate 2007; 67: 341–7.Direct Link:
- 24, , . Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo. FASEB J 2003; 17: 1081–8.
- 25, , , , , , , , , , . Tea polyphenols, their biological effects and potential molecular targets. Histol Histopathol 2008; 23: 487–96.
- 26, , , , . Targeting multiple signaling pathways by green tea polyphenol(-)-epigallocatechin-3-gallate. Cancer Res 2006; 66: 2500–5.
- 27, , , . Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells. Toxicol Appl Pharmacol 2000; 164: 82–90.
- 28, , , , , , , . Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res 2003; 63: 7563–70.
- 29, , , . A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5′-end of the GSTP1 CpG island. J Biol Chem 2000; 275: 24893–9.
- 30, . Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs? Oncogene 2002; 21: 5394–9.
- 31, . Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells. Cancer Res 2003; 63: 498–504.
- 32, , . Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells. J Biol Chem 2002; 277: 22573–80.
- 33, , . Histone deacetylase and DNA methyltransferase in human prostate cancer. Biochem Biophys Res Commun 2001; 287: 705–13.
- 34, , . DNA hypomethylation and human diseases. Biochim Biophys Acta 2007; 1775: 138–62.
- 35, , , , , , , , , , , , . Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia. Oncogene 2005; 24: 7213–23.
- 36, , , , , , , , . A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer. Invest N Drugs 2000; 18: 83–91.
- 37, , , , , . Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol 2002; 321: 591–9.
- 38, , , , . DNA and RNA as new binding targets of green tea catechins. J Biol Chem 2006; 281: 17446–56.
- 39, . Reactivating the expression of methylation silenced genes in human cancer. Oncogene 2002; 21: 5496–503.
- 40, , , , , , . Chromatin changes on the GSTP1 promoter associated with its inactivation in prostate cancer. Mol Carcinog 2007; 46: 839–46.Direct Link:
- 41, , , , , , , . Hypermethylation of CpG island loci and hypomethylation of LINE-1 and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features. J Pathol 2007; 211: 269–77.Direct Link:
- 42, , , , , , , . Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation. Br J Cancer 2004; 91: 985–94.
- 43, , , , , , , , . Global hypomethylation is common in prostate cancer cells: a quantitative predictor for clinical outcome? Cancer Genet Cytogenet 2005; 156: 31–6.
- 44. Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer. Curr Opin Mol Ther 2007; 9: 231–41.
- 45, , . Epigenetic changes in prostate cancer: implication for diagnosis and treatment. J Natl Cancer Inst 2005; 97: 103–15.
- 46, , . The epigenome as a target for cancer chemoprevention. J Natl Cancer Inst 2003; 95: 1747–57.
- 47, , , , . Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci USA 2001; 98: 10350–5.
- 48, , , , ; JPHC Study Group. Green tea consumption and prostate cancer risk in Japanese men: a prospective study. Am J Epidemiol 2008; 167: 71–7.
- 49, , , . Green tea and the prevention of breast cancer: a case-control study in Southeast China. Carcinogenesis 2007; 28: 1074–8.
- 50, . Tea consumption and ovarian cancer risk in a population-based cohort. Arch Intern Med 2005; 165: 2683–6.

1097-0215/asset/olbannerleft.jpg?v=1&s=45719cd7de57873027993264fcc568b335a8cd56)
1097-0215/asset/olbannerright.jpg?v=1&s=5e0fba63c1309b3036eb9215a0e1e83dd02efd19)
