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Additional Supporting Information may be found in the online version of this article.

FilenameFormatSizeDescription
IJC_25037_sm_suppinfoS1table1.doc45KSupplement I. Table I. CFR eligibility specifications by center. From Newcomb et al., Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer. Cancer Epidemiology, Biomarkers & Prevention. 16(11):2331–43, 2007 Nov. UI: 17982118
IJC_25037_sm_suppinfoS2table2.doc37KSupplement I. Table II. CFR eligibility specifications by center: Clinic-based recruitment
IJC_25037_sm_suppinfosupplementII.doc30KSupplement II. Comparison in age at diagnosis in 1105 parent-child pairs with colorectal cancers using only families with one affected offspring to eliminate the multicase families that more likely are syndromic. The younger age at diagnosis of daughters of affected fathers is still evident.
IJC_25037_sm_suppinfosupplementIII.doc30KSupplement III. Comparison in age at diagnosis in 431 parent-child pairs with colorectal cancers in which DNA mismatch repair (MMR) status was documented as normal in one or both members using only families with one affected offspring to eliminate the multicase families that more likely are syndromic. The younger age at diagnosis of daughters of affected fathers is still evident.
IJC_25037_sm_suppinfosupplementIV.rtf17KSupplement IV. Comparison in age at diagnosis in 932 parent-child pairs with colorectal cancers in which Amsterdam II criteria was not fulfilled, using only families with one affected offspring to eliminate the multicase families that more likely are syndromic. The younger age at diagnosis of daughters of affected fathers is still evident.
IJC_25037_sm_suppinfosupplementV.doc25KSupplement V. Distribution of tumor sites in affected parents
IJC_25037_sm_suppinfosupplementVI.doc47KSupplement VI. Distribution of tumor sites in affected offspring by parental site.
IJC_25037_sm_suppinfosupplementVII.doc163KSupplement VII. Additional detail and analysis on distribution of CRC sites in affected offspring by parental CRC site.
IJC_25037_sm_suppinfosupplementVIII.doc28KSupplement VIII. Ages at diagnosis of colorectal cancer for the men and women with CRC ascertained in the C-CFR whose parents did NOT have a reported colorectal cancer, for comparison to the subjects in the manuscript, all of whom did have an affected parent.

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