Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

Authors

  • Eric J. Jacobs,

    Corresponding author
    1. Department of Epidemiology, American Cancer Society, Atlanta, GA
    • Department of Epidemiology, American Cancer Society, Atlanta, GA, USA
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  • Stephen J. Chanock,

    1. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
    2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Charles S. Fuchs,

    1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
    2. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
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  • Andrea LaCroix,

    1. Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA
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  • Robert R. McWilliams,

    1. Department of Oncology, College of Medicine, Mayo Clinic, Rochester, MN
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  • Emily Steplowski,

    1. Information Management Services, Silver Spring, MD
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  • Rachael Z. Stolzenberg-Solomon,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Alan A. Arslan,

    1. Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY
    2. Department of Environmental Medicine, New York University School of Medicine, New York, NY
    3. NYU Cancer Institute, New York, NY
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  • H. Bas Bueno-de-Mesquita,

    1. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
    2. Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
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  • Myron Gross,

    1. Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, MN
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  • Kathy Helzlsouer,

    1. Prevention and Research Center, Mercy Medical Center, Baltimore, MD
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  • Gloria Petersen,

    1. Department of Health Sciences Research, Mayo Clinic, Rochester, MN
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  • Wei Zheng,

    1. Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN
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  • Ilir Agalliu,

    1. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
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  • Naomi E. Allen,

    1. Cancer Epidemiology Unit, University of Oxford, Oxford, UK
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  • Laufey Amundadottir,

    1. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
    2. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Marie-Christine Boutron-Ruault,

    1. Inserm (Institut National de la Santé et de la Recherche Médicale), France
    2. Institut Gustave Roussy, Villejuif, France
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  • Julie E. Buring,

    1. Division of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    2. Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    3. Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA
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  • Federico Canzian,

    1. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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  • Sandra Clipp,

    1. George W. Comstock Center for Public Health Research and Prevention, Hagerstown, MD
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  • Miren Dorronsoro,

    1. Public Health Division of Gipuzkoa and Ciberespana, Spain
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  • J. Michael Gaziano,

    1. Physicians Health Study, Divisions of Aging, Cardiovascular Disease, and Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    2. Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA
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  • Edward L. Giovannucci,

    1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    2. Department of Nutrition, Harvard School of Public Health, Boston, MA
    3. Department of Epidemiology, Harvard School of Public Health, Boston, MA
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  • Susan E. Hankinson,

    1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    2. Department of Epidemiology, Harvard School of Public Health, Boston, MA
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  • Patricia Hartge,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Robert N. Hoover,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • David J. Hunter,

    1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
    2. Department of Epidemiology, Harvard School of Public Health, Boston, MA
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  • Kevin B. Jacobs,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
    2. BioInformed LLC, Gaithersburg, MD
    3. Core Genotyping Facility, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD
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  • Mazda Jenab,

    1. International Agency for Research on Cancer, Lyon, France
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  • Peter Kraft,

    1. Department of Epidemiology, Harvard School of Public Health, Boston, MA
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  • Charles Kooperberg,

    1. Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA
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  • Shannon M. Lynch,

    1. Division of Cancer Control and Population Science, National Cancer Institute, National Institutes of Health, Bethesda, MD
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  • Malin Sund,

    1. Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden
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  • Julie B. Mendelsohn,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Tracy Mouw,

    1. Department of Epidemiology and Public Health, Imperial College, London, UK
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  • Christina C. Newton,

    1. Department of Epidemiology, American Cancer Society, Atlanta, GA
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  • Kim Overvad,

    1. Department of Cardiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    2. Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
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  • Domenico Palli,

    1. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO Florence, Italy
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  • Petra H.M. Peeters,

    1. Department of Epidemiology and Public Health, Imperial College, London, UK
    2. Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
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  • Aleksandar Rajkovic,

    1. Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, PA
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  • Xiao-Ou Shu,

    1. Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN
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  • Gilles Thomas,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Geoffrey S. Tobias,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Dimitrios Trichopoulos,

    1. Department of Epidemiology, Harvard School of Public Health, Boston, MA
    2. Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
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  • Jarmo Virtamo,

    1. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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  • Jean Wactawski-Wende,

    1. Department of Social and Preventive Medicine, University at Buffalo, SUNY, Buffalo, NY
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  • Brian M. Wolpin,

    1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
    2. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
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  • Kai Yu,

    1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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  • Anne Zeleniuch-Jacquotte

    1. Department of Environmental Medicine, New York University School of Medicine, New York, NY
    2. NYU Cancer Institute, New York, NY
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  • Eric J. Jacobs, Stephen J. Chanock, Charles S. Fuchs, Andrea LaCroix, Robert R. McWilliams, Emily Steplowski, Rachael Z. Stolzenberg-Solomon are members of the writing committee.

  • Eric J. Jacobs, Charles S. Fuchs, Andrea LaCroix, Rachael Z. Stolzenberg-Solomon, Alan A. Arslan, H. Bas Bueno-de-Mesquita, Myron Gross, Kathy Helzlsouer, Gloria Petersen, Wei Zheng are members of the steering committee.

Abstract

A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.

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