Yaxiong Tang and Xuesen Li contributed equally to this work.
Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth
Version of Record online: 28 JAN 2010
Copyright © 2010 UICC
International Journal of Cancer
Volume 127, Issue 8, pages 1758–1768, 15 October 2010
How to Cite
Tang, Y., Li, X., Liu, Z., Simoneau, A. R., Xie, J. and Zi, X. (2010), Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth. Int. J. Cancer, 127: 1758–1768. doi: 10.1002/ijc.25210
- Issue online: 20 AUG 2010
- Version of Record online: 28 JAN 2010
- Manuscript Accepted: 18 JAN 2010
- Manuscript Received: 26 AUG 2009
- AICR. Grant Number: 41493
- NIH. Grant Numbers: CA129793, CA122558
Additional Supporting Information may be found in the online version of this article.
|IJC_25210_sm_suppinfofigs1-2.ppt||869K||Supplementary Figure S1 Knock-down of Bim expression by ShRNAs attenuates the anchorage-independent growth inhibitory effect of FKB on PC-3 and DU145 cells. PC3 or DU145/ShLacZ, PC3 or DU145/ShBim117, and PC3 or DU145/ShBim459 cells were grown in soft agar in six-well plates as described in Materials and Methods and treated with 0.1% DMSO or FKB at the indicated concentrations for 30 days. Qualitative analysis of inhibitory effect of FKB against soft agar colony formation. Representative pictures were shown from three independent experiments. Supplementary Figure S2 FKB did not affect body weight and diet consumption in xenograft model. Each mouse was s.c. injected with 1× 106 DU145 cells. After seven days tumors were approximately the size of 120 mm3, the mice bearing DU145 tumors were randomly divided and pair matched into treatment and control groups of 10 mice each. Daily dosing was begun with vehicle or 50 mg/kg FKB. A, average body weight (g) per mouse. B, average diet consumption (g) per mouse a day. A and B, mean ± SE from 10 mice in each group|
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