Epidemiology

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Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population

  1. Yan Lu1,†,
  2. Jianjian Chen1,†,
  3. Yanbing Ding2,†,
  4. Guangfu Jin1,
  5. Juan Wu1,
  6. Hua Huang1,
  7. Bin Deng2,
  8. Zhaolai Hua3,
  9. Yan Zhou4,
  10. Yongqian Shu5,
  11. Ping Liu5,
  12. Zhibin Hu1,
  13. Jing Shen1,
  14. Yaochu Xu1,
  15. Hongbing Shen1,5,‡,*

Article first published online: 3 FEB 2010

DOI: 10.1002/ijc.25228

Issue

International Journal of Cancer

International Journal of Cancer

Volume 127, Issue 9, pages 2183–2189, 1 November 2010

Additional Information

How to Cite

Lu, Y., Chen, J., Ding, Y., Jin, G., Wu, J., Huang, H., Deng, B., Hua, Z., Zhou, Y., Shu, Y., Liu, P., Hu, Z., Shen, J., Xu, Y. and Shen, H. (2010), Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population. Int. J. Cancer, 127: 2183–2189. doi: 10.1002/ijc.25228

Author Information

  1. 1

    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China

  2. 2

    Department of Gastroenterology, Yang-zhou First People's Hospital, Yangzhou, Jiangsu, China

  3. 3

    Department of Epidemiology, Yang-zhong Cancer Institute, Yangzhong, Jiangsu, China

  4. 4

    Department of Oncology, Yi-xing People's Hospital, Yixing, Jiangsu, China

  5. 5

    Department of Oncology, Jiangsu Key Discipline of Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

  1. †

    Yan Lu, Jianjian Chen and Yanbing Ding contributed equally to this work

  2. ‡

    Fax: +86-25-865-27613

*Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, 140 Hanzhong Rd, Nanjing 210029, China

  1. †

    Yan Lu, Jianjian Chen and Yanbing Ding contributed equally to this work

  2. ‡

    Fax: +86-25-865-27613

Publication History

  1. Issue published online: 26 AUG 2010
  2. Article first published online: 3 FEB 2010
  3. Manuscript Accepted: 28 JAN 2010
  4. Manuscript Received: 12 OCT 2009

Funded by

  • National Natural Science Foundation of China. Grant Numbers: 30700684, 30671814
  • Jiangsu Natural Science Foundation. Grant Number: BK2008221

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Keywords:

  • PSCA;
  • polymorphism;
  • gastric cancer;
  • Chinese population;
  • molecular epidemiology

Abstract

Prostate stem cell antigen (PSCA), a member of the LY-6/Thy-1 family of glycosylphosphatidylinositol-anchored cell surface proteins, is considered to be involved in the cell-proliferation inhibition and/or cell-death induction activity. Two single nucleotide polymorphisms (SNPs) (rs2976392 and rs2294008) in the PSCA gene were recently identified as the susceptibility loci of gastric cancer, especially in diffuse type. Therefore, this study was to investigate whether these 2 SNPs were associated with the risk of gastric cancer in Chinese population. We genotyped rs2976392 and rs2294008 in PSCA in a case–control study including 1,053 incident gastric cancer patients and 1,100 cancer-free controls in a high-risk Chinese population. We found that variant genotypes of rs2976392 (GA/AA) were associated with a significantly 37% increased risk of gastric cancer (adjusted OR =1.37, 95% CI = 1.15–1.62), compared with variant homozygote GG, and the associations were all consistently significant in both intestinal and diffuse subtypes, and among different subgroups stratified by age, sex, drinking or smoking status. Interestingly, a significant multiplicative interaction between rs2976392 (GA/AA) and alcohol drinking was detected on the development of intestinal-type gastric cancer (p = 0.009). However, rs2294008 variant genotypes (CT/TT) were associated with a nonsignificant increased risk of gastric cancer (adjusted OR = 1.14, 95% CI = 0.96–1.36). A small meta-analysis including 5 case–control studies showed undoubtedly associations between PSCA rs2294008 and rs2976392 and gastric cancer risk (OR = 1.83, 95% CI: 1.29–2.60 and OR = 1.84, 95% CI: 1.33–2.56, respectively). These findings provide further evidence supporting that the genetic variants of PSCA gene may contribute to the gastric carcinogenesis.

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