• 1
    Kubota Y, Tomita Y, Tsukigi M, Kurachi H, Motoyama T, Mir LM. A case of perineal malignant melanoma successfully treated with electrochemotherapy. Melanoma Res 2005; 15( 2): 1334.
  • 2
    Beebe SJ, Fox P, Rec LJ, Somers K, Stark RH, Schoenbach KH. Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition. IEEE Trans Plasma Sci 2002; 30( 1): 28692.
  • 3
    Schoenbach KH, Joshi RP, Kolb JF, Chen N, Stacey M, Blackmore PF, Buescher ES, Beebe SJ. Ultrashort electrical pulses open a new gateway into biological cells. Proc IEEE 2004; 92( 7): 112237.
  • 4
    Schoenbach KH, Nuccitelli R, Beebe SJ. Zap Spectr IEEE 2006; 43( 8): 206.
  • 5
    Nuccitelli R, Pliquett U, Chen X, Ford W, James SR, Beebe SJ, Kolb JF, Schoenbach KH. Nanosecond pulsed electric fields cause melanomas to self-destruct. Biochem Biophys Res Commun 2006; 343( 2): 35160.
  • 6
    Chen X, Swanson RJ, Kolb JF, Nuccitelli R, Schoenbach KH. Histopathology of normal skin and melanomas after nanosecond pulsed electric field treatment. Melanoma Res 2009; 19: 361371.
  • 7
    Nuccitelli R, Chen X, Pakhomov AG, Baldwin WH, Sheikh S, Pomicter JL, Ren W, Osgood C, Swanson RJ, Kolb JF, Beebe SJ, Schoenbach KH. A new pulsed electric field therapy for melanoma disrupts the tumor's blood supply and causes complete remission without recurrence. Int J Cancer 2009; 125( 2): 43845.
  • 8
    Vernier PT, Sun Y, Marcu L, Salemi S, Craft CM, Gundersen MA. Calcium bursts induced by nanosecond electric pulses. Biochem Biophys Res Commun 2003; 310( 2): 28695.
  • 9
    White JA, Blackmore PF, Schoenbach KH, Beebe SJ. Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields. J Biol Chem 2004; 279( 22): 2296472.
  • 10
    Lien YC, Kung HN, Lu KS, Jeng CJ, Chau YP. Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis. Histol Histopathol 2008; 23( 11): 1299308.
  • 11
    Fang M, Zhang H, Xue S. Role of calcium in apoptosis of HL-60 cells induced by harringtonine. Sci China C Life Sci 1998; 41( 6): 6007.
  • 12
    Lin YT, Yang JS, Lin HJ, Tan TW, Tang NY, Chaing JH, Chang YH, Lu HF, Chung JG. Baicalein induces apoptosis in SCC-4 human tongue cancer cells via a Ca2+-dependent mitochondrial pathway. In Vivo 2007; 21( 6): 10538.
  • 13
    Ip SW, Weng YS, Lin SY, Mei D, Tang NY, Su CC, Chung JG. The role of Ca+2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells. Anticancer Res 2007; 27( 1A): 37989.
  • 14
    Oshimi Y, Oshimi K, Miyazaki S. Necrosis and apoptosis associated with distinct Ca2+ response patterns in target cells attacked by human natural killer cells. J Physiol 1996; 495( Pt 2): 31929.
  • 15
    Oshimi Y, Miyazaki S. Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level. J Immunol 1995; 154( 2): 599609.
  • 16
    Pakhomov AG, Kolb JF, White JA, Joshi RP, Xiao S, Schoenbach KH. Long-lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric field (nsPEF). Bioelectromagnetics 2007; 28( 8): 65563.
  • 17
    Vernier PT, Sun Y, Wang J, Mya TM, Garon E, Valderrabano M, Marcu L, Phillip KH, Gundersen M. Nanoelectropulse intracellular perturbation and electropermeabilization technology: phospholipid translocation, calcium bursts, chromatin rearrangement, cardiomyocyte activation, and tumor cell sensitivity. Conf Proc IEEE Eng Med Biol Soc 2005; 6: 58503.
  • 18
    Vernier PT, Ziegler MJ, Sun Y, Gundersen MA, Tieleman DP. Nanopore-facilitated, voltage-driven phosphatidylserine translocation in lipid bilayers—in cells and in silico. Phys Biol 2006; 3( 4): 23347.
  • 19
    Vernier PT, Sun Y, Marcu L, Craft CM, Gundersen MA. Nanoelectropulse-induced phosphatidylserine translocation. Biophys J 2004; 86( 6): 40408.
  • 20
    Vernier PT, Sun Y, Marcu L, Craft CM, Gundersen MA. Nanosecond pulsed electric fields perturb membrane phospholipids in T lymphoblasts. FEBS Lett 2004; 572( 1–3): 1038.
  • 21
    Beebe SJ, Fox PM, Rec LJ, Willis EL, Schoenbach KH. Nanosecond, high-intensity pulsed electric fields induce apoptosis in human cells. FASEB J 2003; 17( 11): 14935.
  • 22
    Hall EH, Schoenbach KH, Beebe SJ. Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells. Apoptosis 2007; 12( 9): 172131.
  • 23
    Hall EH, Schoenbach KH, Beebe SJ. Nanosecond pulsed electric fields have differential effects on cells in the S-phase. DNA Cell Biol 2007; 26( 3): 16071.
  • 24
    Hall EH, Schoenbach KH, Beebe SJ. Nanosecond pulsed electric fields (nsPEF) induce direct electric field effects and biological effects on human colon carcinoma cells. DNA Cell Biol 2005; 24( 5): 28391.
  • 25
    Beebe SJ, Blackmore PF, White J, Joshi RP, Schoenbach KH. Nanosecond pulsed electric fields modulate cell function through intracellular signal transduction mechanisms. Physiol Meas 2004; 25( 4): 107793.
  • 26
    Stacey M, Stickley J, Fox P, Statler V, Schoenbach K, Beebe SJ, Buescher S. Differential effects in cells exposed to ultra-short, high intensity electric fields: cell survival. DNA damage, and cell cycle analysis. Mutat Res 2003; 542( 1–2): 6575.
  • 27
    Buescher ES, Schoenbach KH. Effects of submicrosecond, high intensity pulsed electric fields on living cells-intracellular electromanipulation. IEEE Trans Dielectr Electr Insul 2003; 10( 5): 78894.
  • 28
    Tekle E, Oubrahim H, Dzekunov SM, Kolb JF, Schoenbach KH, Chock BP. Selective field effects on intracellular vacuoles and vesicle membranes with nanosecond electric pulses. Biophys J 2005; 89( 1): 27484.
  • 29
    Gowrishankar TR, Weaver JC. Electrical behavior and pore accumulation in a multicellular model for conventional and supra-electroporation. Biochem Biophys Res Commun 2006; 349( 2): 64353.
  • 30
    Gowrishankar TR, Esser AT, Vasilkoski Z, Smith KC, Weaver JC. Microdosimetry for conventional and supra-electroporation in cells with organelles. Biochem Biophys Res Commun 2006; 341( 4): 126676.
  • 31
    Gowrishankar TR, Stewart DA, Weaver JC. Model of a confined spherical cell in uniform and heterogeneous applied electric fields. Bioelectrochemistry 2006; 68( 2): 18190.
  • 32
    Esser AT, Smith KC, Gowrishankar TR, Weaver JC. Towards solid tumor treatment by nanosecond pulsed electric fields. Technol Cancer Res Treat 2009; 8( 4): 289306.
  • 33
    Smith KC, Weaver JC. Active mechanisms are needed to describe cell responses to submicrosecond, megavolt-per-meter pulses: cell models for ultrashort pulses. Biophys J 2008; 95( 4): 154763.
  • 34
    Garon EB, Sawcer D, Vernier PT, Tang T, Sun Y, Marcu L, Gundersen MA, Koeffler HP. In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies. Int J Cancer 2007; 121( 3): 67582.