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A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis

  1. Alexandra Nieters1,2,†,*,
  2. Paige M. Bracci3,
  3. Silvia de Sanjosé4,
  4. Nikolaus Becker1,
  5. Marc Maynadié5,
  6. Yolanda Benavente4,
  7. Lenka Foretova6,
  8. Pierluigi Cocco7,
  9. Anthony Staines8,
  10. Elizabeth A. Holly3,
  11. Paolo Boffetta9,
  12. Paul Brennan9,
  13. Christine F. Skibola10

Article first published online: 27 APR 2010

DOI: 10.1002/ijc.25420

Issue

International Journal of Cancer

International Journal of Cancer

Volume 128, Issue 6, pages 1481–1485, 15 March 2011

Additional Information

How to Cite

Nieters, A., Bracci, P. M., de Sanjosé, S., Becker, N., Maynadié, M., Benavente, Y., Foretova, L., Cocco, P., Staines, A., Holly, E. A., Boffetta, P., Brennan, P. and Skibola, C. F. (2011), A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis. International Journal of Cancer, 128: 1481–1485. doi: 10.1002/ijc.25420

Author Information

  1. 1

    Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

  2. 2

    Molecular Epidemiology, Centre of Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany

  3. 3

    Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA

  4. 4

    Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, CIBERESP, Barcelona, Spain

  5. 5

    Dijon University Hospital, Dijon, France

  6. 6

    Masaryk Memorial Cancer Institute, Brno, Czech Republic

  7. 7

    Department of Public Health, Occupational Health Section, University of Cagliari, Italy

  8. 8

    School of Nursing, Dublin City University, Dublin, Ireland

  9. 9

    International Agency for Research on Cancer, Lyon, France

  10. 10

    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA

  1. †

    Tel.: [+49-(0)761-2707815], Fax: +[49-(0)761-2707760]

*Centre of Chronic Immunodeficiency, Molecular Epidemiology, University Medical Center Freiburg and University of Freiburg, Breisacher Straße 117, 2 OG, 79106 Freiburg

Publication History

  1. Issue published online: 28 JAN 2011
  2. Article first published online: 27 APR 2010
  3. Manuscript Accepted: 15 FEB 2010
  4. Manuscript Received: 5 OCT 2009

Funded by

  • German José Carreas Leukemia Foundation. Grant Number: DJCLS_R04/08 and R07/26f
  • Federal Ministry of Education and Research (BMBF). Grant Number: 01 EO 0803
  • EC 5th Framework Program Quality of Life. Grant Number: QLK4-CT-2000-00422
  • EC 6th Framework Program Food. Grant Number: FOOD-CT-2006-023103
  • Federal Office for Radiation Protection. Grant Number: StSch4261 and StSch4420 (Germany)
  • Spanish Ministry of Health grants CIBERESP. Grant Numbers: 06/02/0073, FIS 08-1555 and Marato TV3 (051210) (Spain)
  • La Fondation de France
  • Compagnia di San Paolo di Torino, Programma Oncologia 2001
  • National Cancer Institute. Grant Numbers: R01-CA45614, R01-CA89745, R01-CA87014, R01-CA104862 and R01-CA122663

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Keywords:

  • lymphoma;
  • TNFRSF5;
  • CD40;
  • polymorphism;
  • epidemiology

Abstract

Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate a functional polymorphism (−1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma. Here, the association of this variant with non-Hodgkin lymphoma (NHL) risk was replicated in a European multicenter study of 855 NHL cases and 1,206 controls. In the combined analysis of 2,617 cases and 3,605 controls, carrying the TT genotype was associated with an increased risk for all NHL (OR = 1.4; p for linear trend = 0.00009), diffuse large B-cell lymphoma (OR = 1.6; p for linear trend = 0.002) and follicular lymphoma (OR = 1.6; p for linear trend = 0.001). These data suggest a possible role of this functional polymorphism in lymphomas originating within the germinal center.

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