Epidemiology

Vitamin D-effective solar UV radiation, dietary vitamin D and breast cancer risk

  1. Kåre Edvardsen1,2,†,*,
  2. Marit B. Veierød3,
  3. Magritt Brustad1,
  4. Tonje Braaten1,
  5. Ola Engelsen2,
  6. Eiliv Lund1

Article first published online: 13 MAY 2010

DOI: 10.1002/ijc.25463

Issue

International Journal of Cancer

International Journal of Cancer

Volume 128, Issue 6, pages 1425–1433, 15 March 2011

Additional Information

How to Cite

Edvardsen, K., Veierød, M. B., Brustad, M., Braaten, T., Engelsen, O. and Lund, E. (2011), Vitamin D-effective solar UV radiation, dietary vitamin D and breast cancer risk. International Journal of Cancer, 128: 1425–1433. doi: 10.1002/ijc.25463

Author Information

  1. 1

    Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway

  2. 2

    Norwegian Institute for Air Research, The Polar Environmental Centre, Tromsø, Norway

  3. 3

    Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway

  1. †

    Tel.: +4777750390, Fax: +4777750376

*Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway

Publication History

  1. Issue published online: 28 JAN 2011
  2. Article first published online: 13 MAY 2010
  3. Manuscript Accepted: 29 APR 2010
  4. Manuscript Received: 13 JAN 2010

Funded by

  • European Commission. Grant Number: 018385-2
  • Sparebanken Nord Norge. Grant Number: DL 200701641-75 ID 59
  • Norwegian Cancer Society, Norwegian Foundation for Health and Rehabilitation, Department of Community Medicine at the University of Tromsø, Norwegian Institute for Air Research

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Keywords:

  • vitamin D;
  • breast cancer;
  • UV radiation;
  • cohort study

Abstract

Vitamin D is well known for its important role in calcium and phosphor homeostasis. Recent research suggests that vitamin D also prevent some type of cancers. We studied solar vitamin D effective UV radiation (VD dose), dietary vitamin D, sun-seeking holidays, use of solarium, frequency of sunburn and breast cancer risk in a large population-based cohort study. A total of 41,811 women from the prospective Norwegian Women and Cancer Study, aged 40–70 years at baseline, were followed from 1997/1998 to 2007. Dietary vitamin D intake was calculated at baseline. Information on historical VD dose was used as a proxy for cutaneously obtained vitamin D status. Cox proportional hazards model was used. We adjusted for age, height, BMI, baseline menopausal status, use of hormone replacement therapy, use of oral contraception, alcohol, mother's history of breast cancer, mammography and parity. During 8.5 years of follow-up, 948 new cases of breast cancer were registered using data from the Norwegian Cancer Registry. We found no significant associations between VD dose, or vitamin D intake, or sun-seeking holidays, or use of solarium, or frequency of sunburn, and breast cancer risk. Relative risks (95% confidence intervals) for highest versus lowest category were 1.17 (0.95–1.44), 0.95 (0.75–1.21), 1.07 (0.87–1.32), 0.93 (0.76–1.14) and 1.10 (0.89–1.36), respectively. Our results do not support an association between vitamin D status, and breast cancer risk.

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