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Associations of aspirin, nonsteroidal anti-inflammatory drug and paracetamol use with PSA-detected prostate cancer: Findings from a large, population-based, case–control study (the ProtecT study)
Article first published online: 20 MAY 2010
DOI: 10.1002/ijc.25465
Copyright © 2010 UICC
Additional Information
How to Cite
Murad, A. S., Down, L., Davey Smith, G., Donovan, J. L., Athene Lane, J., Hamdy, F. C., Neal, D. E. and Martin, R. M. (2011), Associations of aspirin, nonsteroidal anti-inflammatory drug and paracetamol use with PSA-detected prostate cancer: Findings from a large, population-based, case–control study (the ProtecT study). Int. J. Cancer, 128: 1442–1448. doi: 10.1002/ijc.25465
Publication History
- Issue published online: 20 MAY 2010
- Article first published online: 20 MAY 2010
- Accepted manuscript online: 20 MAY 2010 12:00AM EST
- Manuscript Accepted: 29 APR 2010
- Manuscript Received: 17 FEB 2010
Funded by
- UK National Institute for Health Research Health Technology Assessment Programme. Grant Numbers: 96/20/06, 96/20/99
- ProMPT (Prostate Mechanisms of Progression and Treatment)
- NIHR Comprehensive Biomedical Research Centre Grant
References
- 1, , , . Global Cancer Statistics, 2002. CA Cancer J Clin 2005; 55: 74–108.Direct Link:
- 2, , , , , , , , . Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007; 7: 256–69.
- 3, , . Cyclooxygenase-2 and prostate carcinogenesis. Cancer Lett 2003; 191: 125–35.
- 4, , , , , , , , . Expression of cyclooxygenase-2 in prostate carcinoma. Cancer 2000; 89: 589–96.Direct Link:
- 5, , , , , , . Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostate. Urology 2000; 56: 671–6.
- 6, , , , , . Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. Urol Res 2001; 29: 25–8.
- 7, , , , , , , , , . A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study. Prostate 2006; 66: 1556–64.Direct Link:
- 8, , , , , . Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA 2005; 294: 914–23.
- 9, , , , , , , . Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the US Preventive Services Task Force. Ann Intern Med 2007; 146: 376.
- 10, , , . Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database. Br Med J 2000; 320: 1642–6.
- 11, , , . Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology 2003; 124: 47–56.
- 12, , , , , . Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis. J Natl Cancer Inst 2003; 95: 1784–91.
- 13, . Breast cancer and NSAID use: a meta-analysis. Br J Cancer 2001; 84: 1188–92.
- 14, , . Daily aspirin use and prostate cancer risk in a large, multiracial cohort in the US. Cancer Causes Control 2002; 13: 427–34.
- 15, , , . Dosage, duration and timing of nonsteroidal antiinflammatory drug use and risk of prostate cancer. Int J Cancer 2003; 106: 409–15.Direct Link:
- 16
- 17, , , , , , . A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence. J Natl Cancer Inst 2005; 97: 975–80.
- 18, , , , , . Association between nonsteroidal anti-inflammatory drugs and prostate cancer occurrence. Cancer J 2006; 12: 130–5.
- 19, , , , , , , , . Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 2009; 101: 432–5.
- 20, , , . Regular use of aspirin and prostate cancer risk (United States). Cancer Causes Control 2006; 17: 251–6.
- 21, , , , , , . Aspirin use in relation to risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2002; 11: 1108–11.
- 22, , , . Aspirin use and chronic diseases: a cohort study of the elderly. Br Med J 1989; 299: 1247–50.
- 23, , . Non-steroidal anti-inflammatory drugs and prostate cancer progression. Int J Cancer 1998; 77: 511–5.Direct Link:
- 24. Association between coronary heart disease and cancers of the breast, prostate, and colon. Cancer Epidemiol Biomarkers Prev 1998; 7: 869–73.
- 25, , , , , , , , . Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging. Cancer Epidemiol Biomarkers Prev 2005; 14: 390–6.
- 26, , , , , , , . Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study. Br J Cancer 2003; 88: 1687–92.
- 27, , . Non-steroidal anti-inflammatory drugs and prostate cancer risk—a population-based case-control study. Eur Urol Suppl 2008; 7: 198.
- 28, , , , , . A population-based study of daily nonsteroidal anti-inflammatory drug use and prostate cancer. Mayo Clin Proc 2002; 77: 219–25.
- 29, , . Use of nonsteroidal anti-inflammatory drugs and prostate cancer risk: a meta-analysis. Int J Cancer 2010;doi:10.1002/ijc.25186.Direct Link:
- 30, , . COX-3: just another COX or the solitary elusive target of paracetamol? Lancet 2003; 361: 981–2.
- 31, , , , , . Decision-making about PSA testing and prostate biopsies: a qualitative study embedded in a primary care randomised trial. Eur Urol 2008; 53: 1186–93.
- 32
- 33, , , , , , , , , , , . Height and prostate cancer risk: a large nested case-control study (ProtecT) and meta-analysis. Cancer Epidemiol Biomarkers Prev 2008; 17: 2325–36.
- 34, , , , , , . Body mass index and risk of prostate cancer in US health professionals. J Natl Cancer Inst 2003; 95: 1240–4.
- 35, . A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006; 15: 2056–62.
- 36, , , , , , . Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis 2007; 66: 158–62.
- 37, . Diabetes and cardiovascular disease. The Framingham study. JAMA 1979; 241: 2035–2038.
- 38, , , , , , , , . Factors associated with initial therapy for clinically localized prostate cancer: prostate cancer outcomes study. J Natl Cancer Inst 2001; 93: 1864–71.
- 39, , , . Prostate-specific antigen and other prostate cancer markers. Urology 2000; 56: 893–8.
- 40, , . Prostate-specific antigen levels in relation to consumption of nonsteroidal anti-inflammatory drugs and acetaminophen. Cancer 2008; 113: 2053–7.Direct Link:
- 41, , , , , , . Association of nonsteroidal anti-inflammatory drugs, prostate specific antigen and prostate volume. J Urol 2009; 181: 2064–70.
- 42, , , , , , , , , . Prevalence of prostate cancer among men with a prostate- specific antigen level ≥4.0 ng per milliliter. N Engl J Med 2004; 350: 2239–46.
- 43, , , , , , , , . Cancer risk in persons receiving prescriptions for paracetamol: a Danish cohort study. Int J Cancer 2002; 97: 96–101.Direct Link:
- 44, , , , . Nonsteroidal antiinflammatory drug discontinuation in patients with osteoarthritis. J Rheumatol 1995; 22: 708–12.
- 45, , , , . Cardiovascular prophylaxis with aspirin: costs of supply and management of upper gastrointestinal and renal toxicity. Br J Clin Pharmacol 2004; 57: 188–98.Direct Link:
- 46, , , . How and why are non-prescription analgesics used in Scotland? Fam Pract 2005; 22: 78–85.
- 47, . Prescription and nonprescription analgesic use in Sweden. Ann Pharmacother 1998; 32: 485–94.
- 48, , , . Asymptomatic incidence and duration of prostate cancer. Am J Epidemiol 1998; 148: 775–85.
- 49, . Screening for prostate cancer: an update. Eur Urol 2008; 53: 37–44.

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