Cancer Therapy

You have full text access to this OnlineOpen article

Multiple antimelanoma potential of dry olive leaf extract

  1. Sanja A. Mijatovic1,†,*,
  2. Gordana S. Timotijevic2,
  3. Djordje M. Miljkovic1,
  4. Julijana M. Radovic1,
  5. Danijela D. Maksimovic-Ivanic1,
  6. Dragana P. Dekanski3,
  7. Stanislava D. Stosic-Grujicic1

Article first published online: 21 JUN 2010

DOI: 10.1002/ijc.25526

Issue

International Journal of Cancer

International Journal of Cancer

Volume 128, Issue 8, pages 1955–1965, 15 April 2011

Additional Information

How to Cite

Mijatovic, S. A., Timotijevic, G. S., Miljkovic, D. M., Radovic, J. M., Maksimovic-Ivanic, D. D., Dekanski, D. P. and Stosic-Grujicic, S. D. (2011), Multiple antimelanoma potential of dry olive leaf extract. Int. J. Cancer, 128: 1955–1965. doi: 10.1002/ijc.25526

Author Information

  1. 1

    Department of Immunology, Institute for Biological Research “Sinisa Stankovic,” Belgrade University, Belgrade, Serbia

  2. 2

    Institute of Molecular Genetics and Genetic Engineering, Belgrade University, Belgrade, Serbia

  3. 3

    Biomedical Research, R&D Institute, Galenika AD, Belgrade, Serbia

  1. †

    Tel.: [+381 11 20 78 390], Fax: +[381 11 27 61 433]

*Department of Immunology, Institute for Biological Research “Sinisa Stankovic”, Belgrade University, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia

Publication History

  1. Issue published online: 22 FEB 2011
  2. Article first published online: 21 JUN 2010
  3. Accepted manuscript online: 21 JUN 2010 12:00AM EST
  4. Manuscript Accepted: 14 JUN 2010
  5. Manuscript Received: 13 MAY 2010

Funded by

  • Serbian Ministry of Science. Grant Number: 143029

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (615K)

References

  • 1
    Hoang MT, Eichenfield LF. The rising incidence of melanoma in children and adolescents. Dermatol Nurs 2000; 12: 188–9, 192–3.
  • 2
    Burlage HM, McKenna GF, Taylor A. Anticancer activity of plant extracts. Tex Rep Biol Med 1956; 14: 538–56.
  • 3
    Legha SS, Ring S, Eton O, Bedikian A, Buzaid AC, Plager C, Papadopoulos N. Development a biochemotherapy regimen with concurrent administration of cisplatin, vinblastine, dacarbazine, interferon α, and interleukin-2 for patients with metastatic melanoma. J Clin Oncol 1998; 16: 1752–9.
  • 4
    Sun W, Schuchter LM. Metastatic melanoma. Curr Treat Options Oncol 2001; 2: 193–202.
  • 5
    Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol 2005; 100: 72–9.
  • 6
    Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007; 70: 461–77.
  • 7
    Waterman E, Lockwood B. Active components and clinical applications of olive oil. Altern Med Rev 2007; 12: 331–42.
  • 8
    Keys A, Menotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Keys MH, et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol 1986; 124: 903–15.
  • 9
    Owen RW, Haubner R, Würtele G, Hull E, Spiegelhalder B, Bartsch H. Olives and olive oil in cancer prevention. Eur J Cancer Prev 2004; 13: 319–26.
  • 10
    Cragg GM, Newman DJ, Yang SS. Natural product extracts of plant and marine origin having antileukemia potential. The NCI experience. J Nat Prod 2006; 69: 488–98.
  • 11
    Escrich E, Moral R, Grau L, Costa I, Solanas M. Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. Mol Nutr Food Res 2007; 51: 1279–92.
  • 12
    Cottet V, Touvier M, Fournier A, Touillaud MS, Lafay L, Clavel-Chapelon F, Boutron-Ruault MC. Postmenopausal breast cancer risk and dietary patterns in the E3N-EPIC prospective cohort study. Am J Epidemiol 2009; 170: 1257–67.
  • 13
    Bosetti C, Pelucchi C, La Vecchia C. Diet and cancer in Mediterranean countries: carbohydrates and fats. Public Health Nutr 2009; 12: 1595–600.
  • 14
    Bitler CM, Viale TM, Damaj B, Crea R. Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. J Nutr 2005; 135: 1475–9.
  • 15
    Visioli F, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sci 1994; 55: 1965–71.
  • 16
    Lee-Huang S, Huang PL, Zhang D, Lee JW, Bao J, Sun Y, Chang YT, Zhang J, Huang PL. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I: fusion [corrected] inhibition. Biochem Biophys Res Commun 2007; 354: 872–8.
  • 17
    Lee-Huang S, Huang PL, Zhang D, Lee JW, Bao J, Sun Y, Chang YT, Zhang J, Huang PL. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: part II: integrase inhibition. Biochem Biophys Res Commun 2007; 354: 879–84.
  • 18
    Hamdi HK, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem Biophys Res Commun 2005; 334: 769–78.
  • 19
    Miljković D, Dekanski D, Miljković Z, Momcilović M, Mostarica-Stojkovic M. Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis. Clin Nutr 2009; 28: 346–50.
  • 20
    Cvjeticanin T, Miljkovic Dj, Stojanovic I, Dekanski D, Stosic-Grujicic S. Dried leaf extract of Olea europaea ameliorates islet-directed autoimmunity in mice. Br J Nutr 2010; 103: 1413–24.
  • 21
    Juven B, Henis Y. Studies on the antimicrobial activity of olive phenolic compounds. J Appl Bacteriol 1970; 33: 721–32.
  • 22
    Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, Fernandez-Gutierrez A, Segura-Carretero A. Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer 2007; 7: 80.
  • 23
    Abaza L, Talorete TP, Yamada P, Kurita Y, Zarrouk M, Isoda H. Induction of growth inhibition and differentiation of human leukemia HL-60 cells by a Tunisian Gerboui olive leaf extract. Biosci Biotechnol Biochem 2007; 71: 1306–12.
  • 24
    Goulas V, Exarchou V, Troganis AN, Psomiadou E, Fotsis T, Briasoulis E, Gerothanassis IP. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res 2009; 53: 600–8.
    Direct Link:
  • 25
    Dekanski D, Janicijevic-Hudomal S, Tadic V, Markovic G, Arsic I, Mitrovic DM. Phytochemical analysis and gastroprotective activity of an olive leaf extract. J Serb Chem Soc 2009; 74: 367–77.
  • 26
    Boreham CJ, Broomhead JA, Fairlie DP. A platinum-195 and nitrogen-15 NMR study of the anticancer drug cis-diamminedichloroplatinum (II) and its hydrolysis and oligomerization products. Aust J Chem 1981; 34: 659–64.
  • 27
    Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55–63.
  • 28
    Flick DA, Gifford GE. Comparison of in vitro cell cytotoxic assays for tumor necrosis factor. J Immunol Methods 1984; 68: 167–75.
  • 29
    Mijatovic S, Maksimovic-Ivanic D, Mojic M, Malaponte G, Libra M, Cardile V, Miljkovic D, Harhaji L, Dabideen D, Cheng KF, Bevelacqua Y, Donia M, et al. Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells. Nitric Oxide 2008; 2: 177–83.
  • 30
    Maksimovic-Ivanic D, Mijatovic S, Harhaji L, Miljkovic D, Dabideen D, Fan Cheng K, Mangano K, Malaponte G, Al-Abed Y, Libra M, Garotta G, Nicoletti F, Stosic-Grujicic S. Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo. Mol Cancer Ther 2008; 7: 510–20.
  • 31
    Lee TJ, Kim EJ, Kim S, Jung EM, Park JW, Jeong SH, Park SE, Yoo YH, Kwon TK. Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells. Mol Cancer Ther 2006; 5: 2398–407.
  • 32
    Karmakar S, Davis KA, Choudhury SR, Deeconda A, Banik NL, Ray SK. Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. Biochem Biophys Res Commun 2009; 388: 705–10.
  • 33
    O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 1998; 17: 384–95.
  • 34
    Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Köntgen F, Adams JM, Strasser A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999; 286: 1735–8.
  • 35
    Liu X, Dai S, Zhu Y, Marrack P, Kappler JW. The structure of a Bcl-XL/Bim fragment complex: implications for Bim function. Immunity 2003; 19: 341–52.
  • 36
    Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A 1999; 96: 13777–82.
  • 37
    Yang TM, Barbone D, Fennell DA, Broaddus VC. Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids. Am J Respir Cell Mol Biol 2009; 41: 14–23.
  • 38
    Fabiani R, De Bartolomeo A, Rosignoli P, Servili M, Selvaggini R, Montedoro GF, Di Saverio C, Morozzi G. Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation. J Nutr 2006; 136: 614–9.
  • 39
    López-Lázaro M. Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 2009; 9: 31–59.
  • 40
    HemaIswarya S, Doble M. Potential synergism of natural products in the treatment of cancer. Phytother Res 2006; 20: 239–49.
    Direct Link:
  • 41
    Al-Katib AM, Sun Y, Goustin AS, Azmi AS, Chen B, Aboukameel A, Mohammad RM. SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status. J Hematol Oncol 2009; 2: 8.
  • 42
    Michalak E, Villunger A, Erlacher M, Strasser A. Death squads enlisted by the tumour suppressor p53. Biochem Biophys Res Commun 2005; 331: 786–98.
  • 43
    Vaseva AV, Moll UM. The mitochondrial p53 pathway. Biochim Biophys Acta 2009; 1787: 414–20.
  • 44
    Schäfer, U, Schneider A, Neugebauer E. Identification of a nitric oxide-regulated zinc finger containing transcription factor using motif-directed differential display. Biochim Biophys Acta 2000; 1494: 269–76.
  • 45
    Bonavida B, Khineche S, Huerta-Yepez S, Garban H. Therapeutic potential of nitric oxide in cancer. Drug Resist 2006; 9: 157–73.
  • 46
    Bahi N, Zhang J, Llovera M, Ballester M, Comella JX, Sanchis D. Switch from caspase-dependent to caspase-independent death during heart development: essential role of endonuclease G in ischemia-induced DNA processing of differentiated cardiomyocytes. J Biol Chem 2006; 281: 22943–52.
  • 47
    Prats E, Noel M, Letourneay J, Tiranti V, Vaque J, Debou R, Zeviani M, Corundella L, Ruisse-Carrillo A. Characterization and expression of the mouse endonuclease G gene. DNA Cell Biol 1997; 16: 1111–2.
  • 48
    Soengas MS, Lowe SW. Apoptosis and melanoma chemoresistance. Oncogene 2003; 22: 3138–51.
  • 49
    Mendelsohn AR, Hamer JD, Wang ZB, Brent R. Cyclin D3 activates caspase 2, connecting cell proliferation with cell death. Proc Natl Acad Sci U S A 2002; 99: 6871–6.
  • 50
    Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 2002; 60: 258–74.
View Full Article (HTML) Get PDF (615K)