Specific infiltration of langerin-positive dendritic cells in EBV-infected tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma

Authors

  • Paulo Henrique Braz-Silva,

    1. Inserm ERI 21/EA 4319, Université de Nice, Nice, France
    2. Department of Oral Pathology, University of São Paulo, São Paulo, Brazil
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    • P.H.B.-S. and S.V. contributed equally to this work

  • Sébastien Vitale,

    1. Inserm ERI 21/EA 4319, Université de Nice, Nice, France
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    • P.H.B.-S. and S.V. contributed equally to this work

  • Catherine Butori,

    1. Inserm ERI 21/EA 4319, Université de Nice, Nice, France
    2. Centre Hospitalier Universitaire de Nice, Laboratoire de Pathologie Expérimentale/tumorothèque, Nice, France
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  • Nicolas Guevara,

    1. Inserm ERI 21/EA 4319, Université de Nice, Nice, France
    2. Centre Hospitalier Universitaire de Nice, Département ORL, Nice, France
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  • José Santini,

    1. Centre Hospitalier Universitaire de Nice, Département ORL, Nice, France
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  • Marina Magalhães,

    1. Department of Oral Pathology, University of São Paulo, São Paulo, Brazil
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  • Paul Hofman,

    1. Inserm ERI 21/EA 4319, Université de Nice, Nice, France
    2. Centre Hospitalier Universitaire de Nice, Laboratoire de Pathologie Expérimentale/tumorothèque, Nice, France
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  • Alain Doglio

    Corresponding author
    1. Inserm ERI 21/EA 4319, Université de Nice, Nice, France
    2. Centre Hospitalier Universitaire de Nice, Unité de Thérapie Cellulaire et Génique, Nice, France
    • INSERM ERI 21/EA 4319, Faculté de Médecine, Avenue de Valombrose, 06107 Nice cedex 2, France
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    • Tel: +33 4 92037638


Abstract

We report here the existence of a novel subset of langerin (CD207)-positive, immature dendritic cells (DCs) (CD83neg) abundantly infiltrating Epstein Barr virus (EBV)-infected areas in tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma. These CD207+ DCs differ from conventional epidermal Langerhans cells in their lack of CD1a and CCR6 and their unusual tissue localization. CD207+ DC infiltration strongly correlates with EBV infection because it was neither detected in EBV negative specimens nor in tissues infected with other human viruses. These immature DCs might represent good candidates for induction of the EBV-specific immune response.

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