Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression

Authors

  • Cynthia C. Sprenger,

    1. Department of Medicine, Division of Gerontology, University of Washington, Seattle, WA
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  • Stephen R. Plymate,

    1. Department of Medicine, Division of Gerontology, University of Washington, Seattle, WA
    2. Veterans Affairs Puget Sound Health Care System, Seattle Division, 1660 South Columbian Way, Seattle WA
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  • May J. Reed

    Corresponding author
    1. Department of Medicine, Division of Gerontology, University of Washington, Seattle, WA
    • Department of Medicine, University of Washington, Harborview Medical Center, 325 9th Avenue, Box 359625, Seattle, WA 98104, USA
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    • Tel: 206-897-5331


Abstract

Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview.

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