B.K. and R.S. contributed equally to this work.
The plasmacytoid carcinoma of the bladder—rare variant of aggressive urothelial carcinoma
Article first published online: 1 DEC 2010
Copyright © 2010 UICC
International Journal of Cancer
Volume 129, Issue 2, pages 346–354, 15 July 2011
How to Cite
Keck, B., Stoehr, R., Wach, S., Rogler, A., Hofstaedter, F., Lehmann, J., Montironi, R., Sibonye, M., Fritsche, H. M., Lopez-Beltran, A., Epstein, J. I., Wullich, B. and Hartmann, A. (2011), The plasmacytoid carcinoma of the bladder—rare variant of aggressive urothelial carcinoma. Int. J. Cancer, 129: 346–354. doi: 10.1002/ijc.25700
- Issue published online: 18 MAY 2011
- Article first published online: 1 DEC 2010
- Accepted manuscript online: 28 SEP 2010 09:36AM EST
- Manuscript Accepted: 17 AUG 2010
- Manuscript Received: 17 FEB 2010
- ELAN Fonds of the University of Erlangen
- urothelial carcinoma;
The WHO 2004 classification defines new histological and molecular variants of urothelial carcinoma. However, there are limited data available on the clinicopathological characteristics or prognosis of these variants. We present histopathological, molecular and clinical data of 32 plasmacytoid carcinomas of the bladder (PUC) showing that PUC is a high-grade tumor with molecular features of aggressive urothelial carcinoma, usually diagnosed in advanced pathological stage (64% pT3, 23% pT4) showing metastases in 60% of the patients. Average survival of our cohort of PUC treated with radical cystectomy and adjuvant chemotherapy was lower than what is typically seen for comparable conventional urothelial carcinomas. Eighty-seven percent of the PUCs showed a negative or strongly reduced membranous staining of E-cadherin. β-Catenin staining was negative in 22.5%, and 16.7% of the remaining tumors showed nuclear accumulation. Aberrant CK20 expression (negative or >10% of cells stained) and negative CK7 staining was found in 100% and 22.6%, respectively. Ninety-seven percent revealed positive staining for PAN-CK. CD138 was positive in 78%, whereas MUM-1 expression was negative in all cases. Multitarget fluorescence in situ hybridization showed all PUCs to be highly aneuploid and polysomic. Deletions on chromosome 9p21 seem to play an important role in this variant. FGFR3 and PIK3CA mutation analyses yielded no mutations in any of the PUCs analyzed. TP53 mutation analysis showed mutations in 29%. In summary, PUC is an aggressive variant of bladder cancer with molecular features of advanced bladder cancer and evidence of WNT pathway activation in some of the cases.