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Short Report
Effects of antihistamine and anti-inflammatory medication use on risk of specific glioma histologies
Article first published online: 4 APR 2011
DOI: 10.1002/ijc.25883
Copyright © 2011 UICC
Additional Information
How to Cite
Scheurer, M. E., Amirian, E. S., Davlin, S. L., Rice, T., Wrensch, M. and Bondy, M. L. (2011), Effects of antihistamine and anti-inflammatory medication use on risk of specific glioma histologies. Int. J. Cancer, 129: 2290–2296. doi: 10.1002/ijc.25883
Publication History
- Issue published online: 26 AUG 2011
- Article first published online: 4 APR 2011
- Accepted manuscript online: 28 DEC 2010 09:25AM EST
- Manuscript Accepted: 8 DEC 2010
- Manuscript Received: 11 OCT 2010
Funded by
- National Cancer Institute. Grant Numbers: R01CA070917, R01CA052689, P50CA097257, K07CA131505
- National Brain Tumor Foundation (Jean Lodgsdon Epidemiology Grant)
- the UCSF Lewis Chair in Brain Tumor Research, and donations from families and friends of J. Berardi, H. Glaser and E. Olsen
- Abstract
- Article
- References
- Cited By
Keywords:
- glioma;
- glioblastoma;
- epidemiology;
- histamine antagonists;
- anti-inflammatory agents
Abstract
Several studies have shown a decrease in glioma risk associated with a personal history of allergic conditions and the medications used to treat the symptoms. However, few studies have been able to examine risk within histological subgroups of glioma. Case–control data from M. D. Anderson Cancer Center and University of California, San Francisco were pooled to conduct the analysis stratified by histological subtype. A risk prediction model considering inflammation-related variables and antihistamine use was built using logistic regression. Of the subtypes examined, long-term antihistamine use was associated with increased risk of anaplastic gliomas, especially when length of use was considered in conjunction with history of asthma or allergy. Anaplastic cases with no history of asthma or allergy were 2.94 times more likely than controls to report antihistamine use for 10 years or more; whereas anaplastic cases with a history of asthma or allergy were 2.34 times more likely than controls to report antihistamine use for 10 years or more. Furthermore, anti-inflammatory medication use was associated with a protective effect against glioblastoma (OR = 0.80; 95% CI: 0.65, 0.99), especially among individuals with no history of asthma or allergies. No statistically significant effects of anti-inflammatory drugs or antihistamines were evident for the other histological subtypes. Thus, modulation of the immune system by the use of common drugs, such as antihistamines or nonsteroidal anti-inflammatory drugs, may contribute to the development of certain types of brain tumors.