W.Z., Y.L., and S.X.L contributed equally to this work.
Cancer Cell Biology
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Expression of CD147 is associated with prostate cancer progression
Article first published online: 27 APR 2011
DOI: 10.1002/ijc.25982
Copyright © 2011 UICC
Additional Information
How to Cite
Zhong, W.-d., Liang, Y.-x., Lin, S. X., Li, L., He, H.-c., Bi, X.-c., Han, Z.-d., Dai, Q.-s., Ye, Y.-k., Chen, Q.-b., Wang, Y.-s., Zeng, G.-h., Zhu, G., Zhang, Z., Chen, Z.-n. and Wu, C.-L. (2012), Expression of CD147 is associated with prostate cancer progression. Int. J. Cancer, 130: 300–308. doi: 10.1002/ijc.25982
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W.Z., Y.L., and S.X.L contributed equally to this work.
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Tel : 617-726-8454, Fax: +1-617-724-7803
Publication History
- Issue published online: 23 NOV 2011
- Article first published online: 27 APR 2011
- Accepted manuscript online: 15 FEB 2011 01:16PM EST
- Manuscript Accepted: 5 JAN 2011
- Manuscript Received: 2 AUG 2010
Funded by
- Natural Science Foundation of Guangdong Province. Grant Number: 04003650
- Key Programs of Health Bureau of Guangzhou city. Grant Number: 2007-Zdi-05
- National High Technology Research and Development Project of China. Grant Numbers: 2006AA02A245, 2007AA022001
- National Natural Science Foundation of China. Grant Number: 30872960
- Guangdong Province (Provincial Key Research Laboratory on Prostate Disease)
- John and Claire Bertucci Prostate Cancer Foundation
References
- 1. Watchful waiting as a treatment option for localized prostate cancer in the PSA era. Jpn J Clin Oncol 2003; 33: 1–5.
- 2. Targeted therapy of cancer: new roles for pathologists—prostate cancer. Mod Pathol 2008; 21( Suppl. 2): S44–55.
- 3, , , ; Guideline Development Group. Diagnosis and treatment of prostate cancer: summary of NICE guidance. BMJ 2008; 336: 610–2.
- 4, , , , , , , , , , . Long-term outcome among men with conservatively treated localised prostate cancer. Br J Cancer 2006; 95: 1186–94.
- 5, , , , , , , , , , . Nomogram incorporating PSA level to predict cancer-specific survival for men with clinically localized prostate cancer managed without curative intent. Cancer 2008; 112: 69–74.
- 6, , . Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas. Am J Pathol 2005; 166: 209–219.
- 7, , , . Tumor–stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res 2004; 2: 73–80.
- 8, , , , , , . Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res 2005; 65: 3193–9.
- 9, , , , , , , . Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res 2004; 64: 1229–32.
- 10, , , , , , , , , , , . Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to anoikis through inhibition of Bim. J Biol Chem 2006; 281: 9719–27.
- 11, , , , , , , , , . Increased EMMPRIN (CD 147) expression during oral carcinogenesis. Exp Mol Pathol 2006; 80: 147–59.
- 12, , . Plasma MMP-9 (92 kDa-MMP) activity is useful in the follow-up and in the assessment of prognosis in breast cancer patients. Int J Cancer 2003; 106: 745–51.
- 13, , . Prognostic impact of matrix metalloproteinase-9 in operable non-small cell lung cancer. Int J Cancer 2003; 103: 647–651.
- 14, . Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer 2002; 99: 157–166.
- 15, , , , , . Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells. Cancer Lett 2007; 248: 211–8.
- 16, , , . The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol 2005; 29: 1228–42.
- 17, , , , , , , , , , . CD147 Expression indicates unfavourable prognosis in prostate Cancer. Pathol Oncol Res 2009; 15: 369–74.
- 18, , , , , , , , , , . Expression and clinical significance of CD147 in genitourinary carcinomas. J Surgical Res 2010; 160: 260–7.
- 19, , , , , , , , , , . CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value. Cancer Invest 2009; 27: 788–93.
- 20, , . Inhibitory effects of antisense RNA of HAb18G/CD147 on invasion of hepatocellular carcinoma cells in vitro. World J Gastroenterol 2003; 9: 2174–7.
- 21, , . Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Cancer Res 2001; 61: 2276–81.
- 22, , , , . The microvesicle as a vehicle for EMMPRIN in tumor–stromal interactions. Oncogene 2004; 23: 956–63.
- 23, , , , , , , . Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas. J Pathol 2004; 202: 341–51.
- 24, , , , , . Increasing EMMPRIN and matriptase expression in hepatocellular carcinoma: tissue microarray analysis of immunohistochemical scores with clinicopathological parameters. Histopathology 2006; 49: 388–95.
- 25, , , , , , , . Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis. Br J Cancer 2006; 95: 1371–8.
- 26, , , , , , , , , , , . CD147 and matrix metalloproteinase-2 protein expression as significant prognostic factors in esophageal squamous cell carcinoma. Cancer 2004; 101: 1994–2000.
- 27, , , , . EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma. Clin Exp Metastasis 2003; 20: 161–9.
- 28, , , , , , . Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression. Clin Cancer Res 2004; 10: 7335–46.

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