Epidemiology

Dietary fat and meat intakes and risk of reflux esophagitis, Barrett's esophagus and esophageal adenocarcinoma†

  1. Mark G. O'Doherty1,‡,*,
  2. Marie M. Cantwell1,
  3. Liam J. Murray1,
  4. Lesley A. Anderson1,
  5. Christian C. Abnet2,
  6. on behalf of the FINBAR Study Group

Article first published online: 22 JUL 2011

DOI: 10.1002/ijc.26108

Issue

International Journal of Cancer

International Journal of Cancer

Volume 129, Issue 6, pages 1493–1502, 15 September 2011

Additional Information

How to Cite

O'Doherty, M. G., Cantwell, M. M., Murray, L. J., Anderson, L. A., Abnet, C. C. and on behalf of the FINBAR Study Group (2011), Dietary fat and meat intakes and risk of reflux esophagitis, Barrett's esophagus and esophageal adenocarcinoma. International Journal of Cancer, 129: 1493–1502. doi: 10.1002/ijc.26108

Author Information

  1. 1

    Cancer Epidemiology Health Services Research Group, Centre for Public Health, Queens University Belfast, Belfast, Northern Ireland, United Kingdom

  2. 2

    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD

  1. ‡

    Tel: +44-(0)-2890633078, Fax: +44-(0)-2890231907

*Cancer Epidemiology Health Services Research Group, Centre for Public Health, Queens University Belfast, Institute of Clinical Sciences, Block B, Grosvenor Road, Belfast BT12 6BA, United Kingdom

  1. †

    Conflict of interest: None

Publication History

  1. Issue published online: 22 JUL 2011
  2. Article first published online: 22 JUL 2011
  3. Accepted manuscript online: 31 MAR 2011 12:22PM EST
  4. Manuscript Accepted: 9 MAR 2011
  5. Manuscript Received: 20 AUG 2010

Funded by

  • Health and Social Care Research & Development Office (Belfast, Northern Ireland) and the Intramural Research Program of the National Institutes of Health
  • National Cancer Institute (Bethesda, MD, USA) (All-Ireland National Cancer Institute Cancer Consortium Joint Research Project in Cancer)
  • Health Research Board (Dublin, Ireland), Ulster Cancer Foundation (Belfast, Northern Ireland)

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Keywords:

  • adenocarcinoma;
  • Barrett's esophagus;
  • dietary fat;
  • epidemiology;
  • meat

Abstract

The aim of our study was to investigate whether dietary fat and meat intakes are associated with reflux esophagitis (RE), Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). In this all-Ireland case–control study, dietary intake data were collected using a food frequency questionnaire in 219 RE patients, 220 BE patients, 224 EAC patients and 256 frequency-matched controls between 2002 and 2005. Unconditional multiple logistic regression analysis was used to examine the association between dietary variables and disease risk using quartiles of intake, to attain odds ratios (ORs) and 95% confidence intervals (95% CIs), while adjusting for potential confounders. Patients in the highest quartile of total fat intake had a higher risk of RE (OR = 3.54; 95% CI = 1.32–9.46) and EAC (OR = 5.44; 95% CI = 2.08–14.27). A higher risk of RE and EAC was also reported for patients in the highest quartile of saturated fat intake (OR = 2.79; 95% CI = 1.11–7.04; OR = 2.41; 95% CI = 1.14–5.08, respectively) and monounsaturated fat intake (OR = 2.63; 95% CI = 1.01–6.86; OR = 5.35; 95% CI = 2.14–13.34, respectively). Patients in the highest quartile of fresh red meat intake had a higher risk of EAC (OR = 3.15; 95% CI = 1.38–7.20). Patients in the highest category of processed meat intake had a higher risk of RE (OR = 4.67; 95% CI = 1.71–12.74). No consistent associations were seen for BE with either fat or meat intakes. Further studies investigating the association between dietary fat and food sources of fat are needed to confirm these results.

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