• 1
    Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 1995; 87: 176776.
  • 2
    Erdman JW Jr, Ford NA, Lindshield BL. Are the health attributes of lycopene related to its antioxidant function? Arch Biochem Biophys 2009; 483: 22935.
  • 3
    Engelmann N, Clinton SK, Erdman JW Jr. Nutritional aspects of phytoene and phytofluene, carotenoid precursors to lycopene. Adv Nutr 2011; 2: 5161.
  • 4
    Boileau TW, Clinton SK, Zaripheh S, Monaco MH, Donovan SM, Erdman JW Jr. Testosterone and food restriction modulate hepatic lycopene isomer concentrations in male F344 rats. J Nutr 2001; 131: 174652.
  • 5
    Kumar NB, Besterman-Dahan K, Kang L, Pow-Sang J, Xu P, Allen K, Riccardi D, Krischer JP. Results of a randomized clinical trial of the action of several doses of lycopene in localized prostate cancer: administration prior to radical prostatectomy. Clin Med Urol 2008; 1: 114.
  • 6
    Campbell JK, Stroud CK, Nakamura MT, Lila MA, Erdman JW Jr. Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. J Nutr 2006; 136: 281319.
  • 7
    Herzog A, Siler U, Spitzer V, Seifert N, Denelavas A, Hunziker PB, Hunziker W, Goralczyk R, Wertz K. Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate. FASEB J 2005; 19: 2724.
  • 8
    Akaza H, Kanetake H, Tsukamoto T, Miyanaga N, Sakai H, Masumori N, Nakatsu H, Sagiyama K, Sakamoto S, Endo Y, Yamanouchi T; REDUCE Study Group. Efficacy and safety of dutasteride on prostate cancer risk reduction in Asian men: the results from the REDUCE study. Jpn J Clin Oncol 2011; 41: 41723.
  • 9
    Unger JM, Thompson IM Jr, LeBlanc M, Crowley JJ, Goodman PJ, Ford LG, Coltman CA Jr. Estimated impact of the prostate cancer prevention trial on population mortality. Cancer 2005; 103: 137580.
  • 10
    Wang S, DeGroff VL, Clinton SK. Tomato and soy polyphenols reduce insulin-like growth factor-I-stimulated rat prostate cancer cell proliferation and apoptotic resistance in vitro via inhibition of intracellular signaling pathways involving tyrosine kinase. J Nutr 2003; 133: 236776.
  • 11
    Canene-Adams K, Campbell JK, Zaripheh S, Jeffery EH, Erdman JW Jr. The tomato as a functional food. J Nutr 2005; 135: 122630.
  • 12
    Wyss A, Wirtz GM, Woggon WD, Brugger R, Wyss M, Friedlein A, Riss G, Bachmann H, Hunziker W. Expression pattern and localization of β,β-carotene 15,15′-dioxygenase in different tissues. Biochem J 2001; 354( Pt 3): 5219.
  • 13
    Ford NA, Clinton SK, von Lintig J, Wyss A, Erdman JW Jr. Loss of carotene-9′,10′-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice. J Nutr 2010; 140: 21348.
  • 14
    Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM, Wang XD. The biochemical characterization of ferret carotene-9′,10′-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. J Biol Chem 2006; 281: 1932738.
  • 15
    Lindshield BL, King JL, Wyss A, Goralczyk R, Lu CH, Ford NA, Erdman JW Jr. Lycopene biodistribution is altered in 15,15′-carotenoid monooxygenase knockout mice. J Nutr 2008; 138: 236771.
  • 16
    Hessel S, Eichinger A, Isken A, Amengual J, Hunzelmann S, Hoeller U, Elste V, Hunziker W, Goralczyk R, Oberhauser V, von Lintig J, Wyss A. CMO1 deficiency abolishes vitamin A production from β-carotene and alters lipid metabolism in mice. J Biol Chem 2007; 282: 3355361.
  • 17
    Jeyaraj DA, Grossman G, Petrusz P. Altered bioavailability of testosterone in androgen-binding protein-transgenic mice. Steroids 2005; 70: 70414.
  • 18
    Ford NA, Elsen AC, Zuniga K, Lindshield BL, Erdman JW. Lycopene and apo-12′-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells. Nutr Cancer 2011; 63: 25663.
  • 19
    Wertz K, Siler U, Goralczyk R. Lycopene: modes of action to promote prostate health. Arch Biochem Biophys 2004; 430: 12734.
  • 20
    Sharoni Y, Danilenko M, Dubi N, Ben-Dor A, Levy J. Carotenoids and transcription. Arch Biochem Biophys 2004; 430: 8996.
  • 21
    Allen CM, Schwartz SJ, Craft NE, Giovannucci EL, De Groff VL, Clinton SK. Changes in plasma and oral mucosal lycopene isomer concentrations in healthy adults consuming standard servings of processed tomato products. Nutr Cancer 2003; 47: 4856.
  • 22
    Leung WC, Hessel S, Meplan C, Flint J, Oberhauser V, Tourniaire F, Hesketh JE, von Lintig J, Lietz G. Two common single nucleotide polymorphisms in the gene encoding β-carotene 15,15′-monoxygenase alter β-carotene metabolism in female volunteers. FASEB J 2009; 23: 104153.
  • 23
    Tourniaire F, Leung W, Meplan C, Minihane A, Hessel S, von Lintig J, Flint J, Gilbert H, Hesketh J, Lietz G. Consequenes of genetic variations in β-carotene cleavage enzymes in female volunteers. Carotenoid Sci 2008; 12: 57.
  • 24
    Berry SD, Davis SR, Beattie EM, Thomas NL, Burrett AK, Ward HE, Stanfield AM, Biswas M, Ankersmit-Udy AE, Oxley PE, Barnett JL, Pearson JF, et al. Mutation in bovine β-carotene oxygenase 2 affects milk color. Genetics 2009; 182: 9236.
  • 25
    Vage DI, Boman IA. A nonsense mutation in the β-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (ovis aries). BMC Genet 2010; 11: 10.